7MW3

Structure of the SARS-CoV-2 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6

Summary for 7MW3

• Entry DOI: 10.2210/pdb7mw3/pdb
• EMDB information: 24061
• Descriptor: Fab of antibody clone 6, light chain, Fab of antibody clone 6, heavy chain, Spike glycoprotein, ... (6 entities in total)
• Functional Keywords: viral protein, antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 597002.26

Authors

Hu, Y.,Xiong, Y. (deposition date: 2021-05-15, release date: 2022-03-16, Last modification date: 2023-11-01)

• Primary citation: Peng, L.,Hu, Y.,Mankowski, M.C.,Ren, P.,Chen, R.E.,Wei, J.,Zhao, M.,Li, T.,Tripler, T.,Ye, L.,Chow, R.D.,Fang, Z.,Wu, C.,Dong, M.B.,Cook, M.,Wang, G.,Clark, P.,Nelson, B.,Klein, D.,Sutton, R.,Diamond, M.S.,Wilen, C.B.,Xiong, Y.,Chen, S.; Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.; Nat Commun, 13:1638-1638, 2022; PubMed: 35347138; DOI: 10.1038/s41467-022-29288-3

Experimental method

ELECTRON MICROSCOPY (3.15 Å)