2QKI
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![BU of 2qki by Molmil](/molmil-images/mine/2qki) | Human C3c in complex with the inhibitor compstatin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, Complement C3, ... | Authors: | Janssen, B.J.C, Halff, E.F, Lambris, J.D, Gros, P. | Deposit date: | 2007-07-11 | Release date: | 2007-08-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J.Biol.Chem., 282, 2007
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1A1P
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![BU of 1a1p by Molmil](/molmil-images/mine/1a1p) | COMPSTATIN, NMR, 21 STRUCTURES | Descriptor: | COMPSTATIN | Authors: | Morikis, D, Assa-Munt, N, Sahu, A, Lambris, J.D. | Deposit date: | 1997-12-12 | Release date: | 1998-04-08 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Solution structure of Compstatin, a potent complement inhibitor. Protein Sci., 7, 1998
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2XW9
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![BU of 2xw9 by Molmil](/molmil-images/mine/2xw9) | Crystal Structure of Complement Factor D mutant S183A | Descriptor: | COMPLEMENT FACTOR D, GLYCEROL | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | Deposit date: | 2010-11-01 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
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2XWA
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![BU of 2xwa by Molmil](/molmil-images/mine/2xwa) | Crystal Structure of Complement Factor D Mutant R202A | Descriptor: | COMPLEMENT FACTOR D, GLYCEROL | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | Deposit date: | 2010-11-01 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
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2XWJ
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![BU of 2xwj by Molmil](/molmil-images/mine/2xwj) | Crystal Structure of Complement C3b in Complex with Factor B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT C3 BETA CHAIN, ... | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | Deposit date: | 2010-11-04 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
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2XWB
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![BU of 2xwb by Molmil](/molmil-images/mine/2xwb) | Crystal Structure of Complement C3b in complex with Factors B and D | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3B ALPHA' CHAIN, ... | Authors: | Forneris, F, Ricklin, D, Wu, J, Tzekou, A, Wallace, R.S, Lambris, J.D, Gros, P. | Deposit date: | 2010-11-01 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation. Science, 330, 2010
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2I07
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![BU of 2i07 by Molmil](/molmil-images/mine/2i07) | Human Complement Component C3b | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3b, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Janssen, B.J.C, Christodoulidou, A, McCarthy, A, Lambris, J.D, Gros, P. | Deposit date: | 2006-08-10 | Release date: | 2006-10-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structure of C3b reveals conformational changes that underlie complement activity. Nature, 444, 2006
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3OHX
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![BU of 3ohx by Molmil](/molmil-images/mine/3ohx) | |
7BAG
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![BU of 7bag by Molmil](/molmil-images/mine/7bag) | C3b in complex with CP40 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETAMIDE, AMINO GROUP, ... | Authors: | Lamers, C, Xue, X, Smiesko, M, van Son, H, Wagner, B, Sfyroera, G, Gros, P, Lambris, J, Ricklin, D. | Deposit date: | 2020-12-15 | Release date: | 2022-01-12 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors. Nat Commun, 13, 2022
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3D5R
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![BU of 3d5r by Molmil](/molmil-images/mine/3d5r) | Crystal Structure of Efb-C (N138A) / C3d Complex | Descriptor: | Complement C3, Fibrinogen-binding protein | Authors: | Geisbrecht, B.V. | Deposit date: | 2008-05-16 | Release date: | 2008-09-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d. Protein Sci., 17, 2008
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3D5S
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![BU of 3d5s by Molmil](/molmil-images/mine/3d5s) | Crystal Structure of Efb-C (R131A) / C3d Complex | Descriptor: | Complement C3, Fibrinogen-binding protein | Authors: | Geisbrecht, B.V. | Deposit date: | 2008-05-16 | Release date: | 2008-09-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d. Protein Sci., 17, 2008
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5O35
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![BU of 5o35 by Molmil](/molmil-images/mine/5o35) | Structure of complement proteins complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | Deposit date: | 2017-05-23 | Release date: | 2017-06-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nat. Struct. Mol. Biol., 24, 2017
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5O32
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![BU of 5o32 by Molmil](/molmil-images/mine/5o32) | The structure of complement complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Xue, X, Wu, J, Forneris, F, Gros, P. | Deposit date: | 2017-05-23 | Release date: | 2017-06-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.206209 Å) | Cite: | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nat. Struct. Mol. Biol., 24, 2017
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2WII
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![BU of 2wii by Molmil](/molmil-images/mine/2wii) | Complement C3b in complex with factor H domains 1-4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C3 BETA CHAIN, ... | Authors: | Wu, J, Janssen, B.J.C, Gros, P. | Deposit date: | 2009-05-12 | Release date: | 2009-06-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat. Immunol., 10, 2009
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2WIN
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![BU of 2win by Molmil](/molmil-images/mine/2win) | C3 convertase (C3bBb) stabilized by SCIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, ... | Authors: | Wu, J, Janssen, B.J, Gros, P. | Deposit date: | 2009-05-13 | Release date: | 2009-06-09 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nat. Immunol., 10, 2009
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2NOJ
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![BU of 2noj by Molmil](/molmil-images/mine/2noj) | Crystal structure of Ehp / C3d complex | Descriptor: | Complement C3, Efb homologous protein | Authors: | Hammel, M, Geisbrecht, B.V. | Deposit date: | 2006-10-25 | Release date: | 2007-08-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Characterization of Ehp, a Secreted Complement Inhibitory Protein from Staphylococcus aureus. J.Biol.Chem., 282, 2007
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2GOM
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![BU of 2gom by Molmil](/molmil-images/mine/2gom) | |
2GOX
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![BU of 2gox by Molmil](/molmil-images/mine/2gox) | Crystal structure of Efb-C / C3d Complex | Descriptor: | Complement C3, Fibrinogen-binding protein | Authors: | Hammel, M, Geisbrecht, B.V. | Deposit date: | 2006-04-14 | Release date: | 2007-03-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A structural basis for complement inhibition by Staphylococcus aureus. Nat.Immunol., 8, 2007
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3L3O
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![BU of 3l3o by Molmil](/molmil-images/mine/3l3o) | |
3L5N
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![BU of 3l5n by Molmil](/molmil-images/mine/3l5n) | |
3NMS
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![BU of 3nms by Molmil](/molmil-images/mine/3nms) | |
4H6H
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![BU of 4h6h by Molmil](/molmil-images/mine/4h6h) | |
4H6I
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![BU of 4h6i by Molmil](/molmil-images/mine/4h6i) | |
5FO9
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![BU of 5fo9 by Molmil](/molmil-images/mine/5fo9) | Crystal Structure of Human Complement C3b in Complex with CR1 (CCP15- 17) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, ... | Authors: | Forneris, F, Wu, J, Xue, X, Gros, P. | Deposit date: | 2015-11-18 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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5FO8
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![BU of 5fo8 by Molmil](/molmil-images/mine/5fo8) | Crystal Structure of Human Complement C3b in Complex with MCP (CCP1-4) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COMPLEMENT C3, ... | Authors: | Forneris, F, Wu, J, Xue, X, Gros, P. | Deposit date: | 2015-11-18 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode. Embo J., 35, 2016
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