1PB7
 
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1PB8
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1PB9
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1PBQ
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2A5T
 | | Crystal Structure Of The NR1/NR2A ligand-binding cores complex | | Descriptor: | GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ... | | Authors: | Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E. | | Deposit date: | 2005-06-30 | | Release date: | 2005-11-15 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
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2A5S
 | | Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate | | Descriptor: | GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit | | Authors: | Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E. | | Deposit date: | 2005-06-30 | | Release date: | 2005-11-15 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
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6CNA
 | | GluN1-GluN2B NMDA receptors with exon 5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Furukawa, H, Grant, T, Grigorieff, N. | | Deposit date: | 2018-03-07 | | Release date: | 2018-10-03 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
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8USW
 | | CNQX-bound GluN1a-3A NMDA receptor | | Descriptor: | 7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, Glutamate receptor ionotropic, NMDA 1, ... | | Authors: | Michalski, K, Furukawa, H. | | Deposit date: | 2023-10-30 | | Release date: | 2024-04-17 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Structure and function of GluN1-3A NMDA receptor excitatory glycine receptor channel.
Sci Adv, 10, 2024
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2QTS
 | | Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ... | | Authors: | Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E. | | Deposit date: | 2007-08-02 | | Release date: | 2007-09-25 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
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6USV
 | | Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and SDZ 220-040 | | Descriptor: | (2S)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid, GLYCEROL, GLYCINE, ... | | Authors: | Romero-Hernandez, A, Tajima, N, Chou, T, Furukawa, h. | | Deposit date: | 2019-10-28 | | Release date: | 2020-07-15 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.304 Å) | | Cite: | Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
Cell, 182, 2020
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8S90
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8S8Z
 | | Cryo-EM structure of octameric human CALHM1 (I109W) in complex with ruthenium red | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calcium homeostasis modulator protein 1, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | | Authors: | Syrjanen, J.L, Furukawa, H. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.91 Å) | | Cite: | Structure of human CALHM1 reveals key locations for channel regulation and blockade by ruthenium red.
Nat Commun, 14, 2023
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8E96
 | | Glycine and glutamate bound Human GluN1a-GluN2D NMDA receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, GLYCINE, ... | | Authors: | Kang, H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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9ARG
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9ARI
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9ARE
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation | | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2024-02-23 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9ARF
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in nonactive1 conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2024-02-23 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9BIB
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine, glutamate, and EU-1622-A, in open-channel conformation, C1 symmetry | | Descriptor: | GLUTAMIC ACID, GLYCINE, Glutamate receptor, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2024-04-23 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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9ARH
 | | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2024-02-23 | | Release date: | 2024-07-31 | | Last modified: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (3.69 Å) | | Cite: | Molecular mechanism of ligand gating and opening of NMDA receptor.
Nature, 632, 2024
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8E97
 | | PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (4.19 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E94
 | | PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E93
 | | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E92
 | | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E99
 | | Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (4.24 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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8E98
 | | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | | Authors: | Chou, T.-H, Furukawa, H. | | Deposit date: | 2022-08-26 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-14 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
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