1HP4
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1HP5
| STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE COMPLEXED WITH INTERMEDIATE ANALOUGE NAG-THIAZOLINE | Descriptor: | 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, ... | Authors: | Mark, B.L. | Deposit date: | 2000-12-12 | Release date: | 2001-04-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase. J.Biol.Chem., 276, 2001
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1JAK
| Streptomyces plicatus beta-N-acetylhexosaminidase in Complex with (2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidinium chloride (IFG) | Descriptor: | (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | Authors: | Mark, B.L, Vocadlo, D.J, Zhao, D, Knapp, S, Withers, S.G, James, M.N. | Deposit date: | 2001-05-30 | Release date: | 2001-11-21 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor. J.Biol.Chem., 276, 2001
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1NP0
| Human lysosomal beta-hexosaminidase isoform B in complex with intermediate analogue NAG-thiazoline | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, Beta-hexosaminidase subunit beta, ... | Authors: | Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G. | Deposit date: | 2003-01-16 | Release date: | 2003-04-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease J.Mol.Biol., 327, 2003
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1NOW
| Human lysosomal beta-hexosaminidase isoform B in complex with (2R,3R,4S,5R)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium Chloride (GalNAc-isofagomine) | Descriptor: | (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G. | Deposit date: | 2003-01-16 | Release date: | 2003-04-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease J.Mol.Biol., 327, 2003
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1NOU
| Native human lysosomal beta-hexosaminidase isoform B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | Authors: | Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G. | Deposit date: | 2003-01-16 | Release date: | 2003-04-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease J.Mol.Biol., 327, 2003
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6MKQ
| Carbapenemase VCC-1 bound to avibactam | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | Authors: | Mark, B.L, Vadlamani, G. | Deposit date: | 2018-09-26 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam. Antimicrob. Agents Chemother., 63, 2019
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6MK6
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6DTE
| GlcNAc-inspired cyclophellitol bound to NagZ | Descriptor: | 2,2,2-trifluoro-N-[(1R,2R,3R,4R,5R,6R)-2,3,5,6-tetrahydroxy-4-(hydroxymethyl)cyclohexyl]acetamide, Beta-hexosaminidase | Authors: | Mark, B.L, Winogrodzki, J.L. | Deposit date: | 2018-06-15 | Release date: | 2019-04-24 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.929 Å) | Cite: | A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa. Chem. Commun. (Camb.), 54, 2018
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3KOT
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3KOS
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4WKM
| AmpR effector binding domain from Citrobacter freundii bound to UDP-MurNAc-pentapeptide | Descriptor: | ALA-FGA-API-DAL-DAL, GLYCEROL, LysR family transcriptional regulator, ... | Authors: | Vadlamani, G, Reeve, T.M, Mark, B.L. | Deposit date: | 2014-10-02 | Release date: | 2014-12-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The beta-Lactamase Gene Regulator AmpR Is a Tetramer That Recognizes and Binds the d-Ala-d-Ala Motif of Its Repressor UDP-N-acetylmuramic Acid (MurNAc)-pentapeptide. J.Biol.Chem., 290, 2015
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6PEI
| Structure of sorbitol dehydrogenase from Sinorhizobium meliloti 1021 | Descriptor: | Sorbitol dehydrogenase (L-iditol 2-dehydrogenase) | Authors: | Bailey-Elkin, B.A, Kohlmeier, M.G, Oresnik, I.J, Mark, B.L. | Deposit date: | 2019-06-20 | Release date: | 2020-06-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Characterization of the sorbitol dehydrogenase SmoS from Sinorhizobium meliloti 1021 Acta Crystallogr.,Sect.D, 77, 2021
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6PEJ
| Structure of sorbitol dehydrogenase from Sinorhizobium meliloti 1021 bound to sorbitol | Descriptor: | Sorbitol dehydrogenase (L-iditol 2-dehydrogenase), sorbitol | Authors: | Bailey-Elkin, B.A, Kohlmeier, M.G, Oresnik, I.J, Mark, B.L. | Deposit date: | 2019-06-20 | Release date: | 2020-06-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Characterization of the sorbitol dehydrogenase SmoS from Sinorhizobium meliloti 1021 Acta Crystallogr.,Sect.D, 77, 2021
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8EHO
| PRRSV-1 PLP2 domain bound to ubiquitin | Descriptor: | 3-AMINOPROPANE, GLYCEROL, NITRATE ION, ... | Authors: | Bailey-Elkin, B.A, Mark, B.L. | Deposit date: | 2022-09-14 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis. Plos Pathog., 19, 2023
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8EHN
| PRRSV-1 PLP2 domain | Descriptor: | ACETATE ION, Papain-like protease 2, ZINC ION | Authors: | Bailey-Elkin, B.A, Mark, B.L. | Deposit date: | 2022-09-14 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis. Plos Pathog., 19, 2023
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5DN4
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5FCZ
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5FD0
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5DN5
| Structure of a C-terminally truncated glycoside hydrolase domain from Salmonella typhimurium FlgJ | Descriptor: | CHLORIDE ION, IODIDE ION, Peptidoglycan hydrolase FlgJ, ... | Authors: | Zaloba, P, Bailey-Elkin, B.A, Mark, B.L. | Deposit date: | 2015-09-09 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. Plos One, 11, 2016
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5VQE
| Beta-glucoside phosphorylase BglX bound to 2FGlc | Descriptor: | 2-deoxy-2-fluoro-alpha-D-glucopyranose, Beta-glucoside phosphorylase BglX | Authors: | Patel, A, Mark, B.L. | Deposit date: | 2017-05-08 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.889 Å) | Cite: | Structural and mechanistic analysis of a beta-glycoside phosphorylase identified by screening a metagenomic library. J. Biol. Chem., 293, 2018
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5VQD
| Beta-glucoside phosphorylase BglX | Descriptor: | Beta-glucoside phosphorylase BglX, GLYCEROL | Authors: | Patel, A, Mark, B.L. | Deposit date: | 2017-05-08 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and mechanistic analysis of a beta-glycoside phosphorylase identified by screening a metagenomic library. J. Biol. Chem., 293, 2018
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4MO5
| Crystal structure of AnmK bound to AMPPCP and anhMurNAc | Descriptor: | 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, Anhydro-N-acetylmuramic acid kinase, MAGNESIUM ION, ... | Authors: | Bacik, J.P, Mark, B.L. | Deposit date: | 2013-09-11 | Release date: | 2014-01-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Conformational Itinerary of Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase during Its Catalytic Cycle. J.Biol.Chem., 289, 2014
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4MSS
| Crystal structure of Burkholderia cenocepacia family 3 glycoside hydrolase (NagZ) bound to (3S,4R,5R,6S)-3-acetamido-4,5,6-trihydroxyazepane | Descriptor: | Beta-hexosaminidase 1, GLYCEROL, N-[(3S,4R,5R,6S)-4,5,6-trihydroxyazepan-3-yl]acetamide | Authors: | Vadlamani, G, Mark, B.L. | Deposit date: | 2013-09-18 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams. Chem.Commun.(Camb.), 49, 2013
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7MIC
| Maize rayado fino virus protease in complex with Ubiquitin | Descriptor: | 3-AMINOPROPANE, GLYCEROL, RNA replication protein, ... | Authors: | Patel, A, Mark, B.L. | Deposit date: | 2021-04-16 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase. J.Biol.Chem., 297, 2021
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