7UWZ
 
 | | NMR solution structure of the De novo designed small beta-barrel protein 33_bp_sh3 | | Descriptor: | De novo designed small beta-barrel protein 33_bp_sh3 | | Authors: | Peterson, F.C, Kim, D.E, Jensen, D.R, Saleem, A, Chow, C.M, Volkman, B.F, Baker, D. | | Deposit date: | 2022-05-04 | | Release date: | 2023-03-22 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | De novo design of small beta barrel proteins.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7UBH
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8X80
 | | Structure of leptin-LepR trimer with a small gap | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, ... | | Authors: | Xie, Y.F, Gao, G.F. | | Deposit date: | 2023-11-27 | | Release date: | 2024-08-07 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Structural plasticity of human leptin binding to its receptor LepR
Hlife, 1, 2023
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8X81
 | | Structure of leptin-LepR trimer with a large gap | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, ... | | Authors: | Xie, Y.F, Gao, G.F. | | Deposit date: | 2023-11-27 | | Release date: | 2024-08-07 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | Structural plasticity of human leptin binding to its receptor LepR
Hlife, 1, 2023
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8X85
 | | Structure of leptin-LepR dimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor, ... | | Authors: | Xie, Y.F, Shang, G.J, Qi, J.X, Gao, G.F. | | Deposit date: | 2023-11-27 | | Release date: | 2024-08-07 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Structural plasticity of human leptin binding to its receptor LepR
Hlife, 1, 2023
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8X7E
 | | Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With JTE-151 | | Descriptor: | (4~{S})-6-[(2-chloranyl-4-methyl-phenyl)amino]-4-[4-cyclopropyl-5-[3-(2,2-dimethylpropyl)cyclobutyl]-1,2-oxazol-3-yl]-6-oxidanylidene-hexanoic acid, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | | Authors: | Akai, S, Nomura, A, Yamaguchi, K, Adachi, T. | | Deposit date: | 2023-11-24 | | Release date: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery and SAR of JTE-151: A Novel ROR gamma Inhibitor for Clinical Development.
J.Med.Chem., 67, 2024
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7C6S
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7DC6
 | | Giant panda MHC class I complexes | | Descriptor: | Beta-2-microglobulin, CCV-NGY9 peptide from Spike protein, MHC class I antigen | | Authors: | Yuan, H, Xia, C. | | Deposit date: | 2020-10-23 | | Release date: | 2021-06-16 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Crystal structure of the giant panda MHC class I complex: First insights into the viral peptide presentation profile in the bear family.
Protein Sci., 29, 2020
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7BZV
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7BRP
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8YN0
 | | Crystal structure of NRG1C in complex with EDS1-SAG101-(ADPr-ATP) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, Probable disease resistance protein At5g66890, ... | | Authors: | Huang, S, Xiao, Y, Chai, J. | | Deposit date: | 2024-03-10 | | Release date: | 2024-12-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Balanced plant helper NLR activation by a modified host protein complex.
Nature, 639, 2025
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7EJU
 | | Junin virus(JUNV) RNA polymerase L complexed with Z protein | | Descriptor: | MAGNESIUM ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | | Authors: | Chen, Y. | | Deposit date: | 2021-04-02 | | Release date: | 2021-07-07 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis for recognition and regulation of arenavirus polymerase L by Z protein.
Nat Commun, 12, 2021
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7D60
 | | Cryo-EM Structure of human CALHM5 in the presence of rubidium red | | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | Authors: | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | Deposit date: | 2020-09-28 | | Release date: | 2020-12-23 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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8ZAP
 | | ExoC110T class 1 channelrhodopsin | | Descriptor: | C110T-class1, POTASSIUM ION, RETINAL | | Authors: | Zhang, M.F. | | Deposit date: | 2024-04-25 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Channelrhodopsins with distinct chromophores and binding patterns.
Nat Commun, 15, 2024
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8ZAO
 | | ExoKCR1 channelrhodopsin | | Descriptor: | POTASSIUM ION, RETINAL, exoKCR1 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-04-25 | | Release date: | 2024-09-04 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Channelrhodopsins with distinct chromophores and binding patterns.
Nat Commun, 15, 2024
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8ZAN
 | | ExoChR2 channelrhodopsin | | Descriptor: | Archaeal-type opsin 2, RETINAL | | Authors: | Zhang, M.F. | | Deposit date: | 2024-04-25 | | Release date: | 2024-09-04 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Channelrhodopsins with distinct chromophores and binding patterns.
Nat Commun, 15, 2024
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8ZAQ
 | | ExoC110T class 2 channelrhodopsin | | Descriptor: | C110T class2, POTASSIUM ION, RETINAL | | Authors: | Zhang, M.F. | | Deposit date: | 2024-04-25 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Channelrhodopsins with distinct chromophores and binding patterns.
Nat Commun, 15, 2024
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7D65
 | | Cryo-EM Structure of human CALHM5 in the presence of Ca2+ | | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | Authors: | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | Deposit date: | 2020-09-29 | | Release date: | 2020-12-23 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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7D61
 | | Cryo-EM Structure of human CALHM5 in the presence of EDTA | | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | Authors: | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | Deposit date: | 2020-09-28 | | Release date: | 2020-12-23 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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8YN1
 | | Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, Probable disease resistance protein At5g66900, ... | | Authors: | Huang, S, Xiao, Y, Chai, J. | | Deposit date: | 2024-03-10 | | Release date: | 2024-12-11 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Balanced plant helper NLR activation by a modified host protein complex.
Nature, 639, 2025
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7BRO
 | | Crystal structure of the 2019-nCoV main protease | | Descriptor: | 3C-like proteinase | | Authors: | Fu, L.F. | | Deposit date: | 2020-03-29 | | Release date: | 2020-05-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
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8ZAM
 | | EndoChR2 channelrhodopsin | | Descriptor: | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Archaeal-type opsin 2 | | Authors: | Zhang, M.F. | | Deposit date: | 2024-04-25 | | Release date: | 2024-09-11 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Channelrhodopsins with distinct chromophores and binding patterns.
Nat Commun, 15, 2024
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7D1M
 | | CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 | | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, DIMETHYL SULFOXIDE | | Authors: | Fu, L.F, Gilski, M, Shabalin, I, Gao, G.F, Qi, J.X. | | Deposit date: | 2020-09-14 | | Release date: | 2020-10-28 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
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8WQV
 | | Fe-O nanocluster of form-VIII in the 4-fold channel of Ureaplasma diversum ferritin | | Descriptor: | FE (III) ION, Ferritin | | Authors: | Wang, W.M, Ma, D.Y, Gong, W.J, Wu, L.J, Wang, H.F. | | Deposit date: | 2023-10-12 | | Release date: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Growth Process of Fe-O Nanoclusters with Different Sizes Biosynthesized by Protein Nanocages.
J.Am.Chem.Soc., 146, 2024
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8WPT
 | | Truncated mutant (1-171) of ferritin from Ureaplasma diversum | | Descriptor: | CHLORIDE ION, FE (III) ION, Truncated ferritin | | Authors: | Wang, W.M, Xi, H.F, Gong, W.J, Ma, D.Y, Wang, H.F. | | Deposit date: | 2023-10-10 | | Release date: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Growth Process of Fe-O Nanoclusters with Different Sizes Biosynthesized by Protein Nanocages.
J.Am.Chem.Soc., 146, 2024
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