2MT7
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4I7A
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![BU of 4i7a by Molmil](/molmil-images/mine/4i7a) | GrpN pentameric microcompartment shell protein from Rhodospirillum rubrum | Descriptor: | CHLORIDE ION, Ethanolamine utilization protein EutN/carboxysome structural protein Ccml | Authors: | Wheatley, N.M, Gidaniyan, S.D, Cascio, D, Yeates, T.O. | Deposit date: | 2012-11-30 | Release date: | 2013-05-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Bacterial microcompartment shells of diverse functional types possess pentameric vertex proteins. Protein Sci., 22, 2013
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6M2B
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![BU of 6m2b by Molmil](/molmil-images/mine/6m2b) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416 | Descriptor: | 2-[(E)-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-methyl-hydrazinylidene]methyl]benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Li, H. | Deposit date: | 2020-02-27 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell, 11, 2020
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5YTX
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![BU of 5ytx by Molmil](/molmil-images/mine/5ytx) | Crystal structure of YB1 cold-shock domain in complex with UCAACU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*AP*CP*U)-3') | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTT
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![BU of 5ytt by Molmil](/molmil-images/mine/5ytt) | Crystal structure of YB1 cold-shock domain in complex with UCAUGU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*GP*U)-3'), SULFATE ION | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTV
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![BU of 5ytv by Molmil](/molmil-images/mine/5ytv) | Crystal structure of YB1 cold-shock domain in complex with UCAUCU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*CP*U)-3') | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTS
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![BU of 5yts by Molmil](/molmil-images/mine/5yts) | Crystal structure of YB1 cold-shock domain in complex with UCUUCU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*CP*UP*UP*C)-3'), SULFATE ION | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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7XPY
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![BU of 7xpy by Molmil](/molmil-images/mine/7xpy) | Crystal structure of USP7 in complex with its inhibitor | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 7, [(3S,3aR,4R,6Z,9S,10E,11aR)-9-acetyloxy-6-(acetyloxymethyl)-3,10-dimethyl-2-oxidanylidene-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-4-yl] (E)-2-methyl-4-oxidanyl-but-2-enoate | Authors: | Feng, N, Zeng, K.W. | Deposit date: | 2022-05-06 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv, 8, 2022
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3C17
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6M1S
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![BU of 6m1s by Molmil](/molmil-images/mine/6m1s) | The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12o | Descriptor: | 3-[5-[8-(ethylamino)-6-fluoranyl-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]oxy-2,2-dimethyl-propanoic acid, CHLORIDE ION, DNA gyrase subunit B, ... | Authors: | Xu, Z.H, Zhou, Z. | Deposit date: | 2020-02-26 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.254 Å) | Cite: | Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem., 63, 2020
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6M1J
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![BU of 6m1j by Molmil](/molmil-images/mine/6m1j) | The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12x | Descriptor: | 1-[5-[6-fluoranyl-8-(methylamino)-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]cyclopropane-1-carboxylic acid, DIMETHYL SULFOXIDE, DNA gyrase subunit B, ... | Authors: | Xu, Z.H, Zhou, Z. | Deposit date: | 2020-02-26 | Release date: | 2020-09-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem., 63, 2020
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7FBT
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![BU of 7fbt by Molmil](/molmil-images/mine/7fbt) | Crystal structure of chitinase (RmChi1) from Rhizomucor miehei (sp p32 2 1, MR) | Descriptor: | Chitinase, MAGNESIUM ION | Authors: | Jiang, Z.Q, Hu, S.Q, Zhu, Q, Liu, Y.C, Ma, J.W, Yan, Q.J, Gao, Y.G, Yang, S.Q. | Deposit date: | 2021-07-12 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a chitinase (RmChiA) from the thermophilic fungus Rhizomucor miehei with a real active site tunnel. Biochim Biophys Acta Proteins Proteom, 1869, 2021
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5VY6
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![BU of 5vy6 by Molmil](/molmil-images/mine/5vy6) | A self-assembling D-form DNA crystal lattice | Descriptor: | DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*GP*AP*AP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*T)-3'), DNA (5'-D(P*CP*CP*GP*TP*CP*A)-3'), ... | Authors: | Simmons, C.R, Yan, H. | Deposit date: | 2017-05-24 | Release date: | 2017-08-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.064 Å) | Cite: | Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals. J. Am. Chem. Soc., 139, 2017
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5VOX
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![BU of 5vox by Molmil](/molmil-images/mine/5vox) | Yeast V-ATPase in complex with Legionella pneumophila effector SidK (rotational state 1) | Descriptor: | V-type proton ATPase catalytic subunit A,V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Zhao, J. | Deposit date: | 2017-05-03 | Release date: | 2017-06-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathog., 13, 2017
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5VY7
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![BU of 5vy7 by Molmil](/molmil-images/mine/5vy7) | A self-assembling L-form DNA crystal lattice | Descriptor: | DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*GP*AP*AP*CP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*T)-3'), DNA (5'-D(P*CP*CP*GP*TP*CP*A)-3'), ... | Authors: | Simmons, C.R, Yan, H. | Deposit date: | 2017-05-24 | Release date: | 2017-08-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals. J. Am. Chem. Soc., 139, 2017
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5VOY
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![BU of 5voy by Molmil](/molmil-images/mine/5voy) | Yeast V-ATPase in complex with Legionella pneumophila effector SidK (rotational state 2) | Descriptor: | V-type proton ATPase catalytic subunit A,V-type proton ATPase catalytic subunit A, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | Authors: | Zhao, J. | Deposit date: | 2017-05-03 | Release date: | 2017-06-21 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.9 Å) | Cite: | Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathog., 13, 2017
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6A58
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![BU of 6a58 by Molmil](/molmil-images/mine/6a58) | Structure of histone demethylase REF6 | Descriptor: | Lysine-specific demethylase REF6, ZINC ION | Authors: | Tian, Z, Chen, Z. | Deposit date: | 2018-06-22 | Release date: | 2019-06-26 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms. Cell Discov, 6, 2020
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5WOP
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![BU of 5wop by Molmil](/molmil-images/mine/5wop) | High Resolution Structure of Mutant CA09-PB2cap | Descriptor: | GLYCEROL, Polymerase PB2 | Authors: | Constantinides, A.E, Gumpper, R.H, Severin, C, Luo, M. | Deposit date: | 2017-08-02 | Release date: | 2017-12-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding. Acta Crystallogr F Struct Biol Commun, 74, 2018
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4NPY
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![BU of 4npy by Molmil](/molmil-images/mine/4npy) | Crystal structure of germline Fab PGT121, a putative precursor of the broadly reactive and potent HIV-1 neutralizing antibody | Descriptor: | GLYCEROL, germline PGT121 heavy chain, germline PGT121 light chain | Authors: | Julien, J.-P, Diwanji, D.C, Wilson, I.A. | Deposit date: | 2013-11-22 | Release date: | 2013-12-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies. Plos Pathog., 9, 2013
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6A72
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![BU of 6a72 by Molmil](/molmil-images/mine/6a72) | Copper transporter protein | Descriptor: | ATP7B protein, CALCIUM ION, dioxo(di-mu-sulfide)dimolybdenum | Authors: | Chen, W.B. | Deposit date: | 2018-07-01 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein. Nat Commun, 10, 2019
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5X80
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![BU of 5x80 by Molmil](/molmil-images/mine/5x80) | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH SALICYLIC ACID | Descriptor: | 2-HYDROXYBENZOIC ACID, SULFATE ION, Uncharacterized HTH-type transcriptional regulator Rv2887 | Authors: | Gao, Y.R, Li, D.F, Wang, D.C, Bi, L.J. | Deposit date: | 2017-02-28 | Release date: | 2017-08-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis Sci Rep, 7, 2017
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5X88
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![BU of 5x88 by Molmil](/molmil-images/mine/5x88) | A crystal structure of cutinases from Malbranchea cinnamomea | Descriptor: | cutinase | Authors: | Jiang, Z, Yang, S.Q, You, X, Huang, P, Ma, J.W. | Deposit date: | 2017-03-01 | Release date: | 2018-01-31 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | High-level expression and characterization of a novel cutinase from Malbranchea cinnamomea suitable for butyl butyrate production. Biotechnol Biofuels, 10, 2017
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6A59
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![BU of 6a59 by Molmil](/molmil-images/mine/6a59) | Structure of histone demethylase REF6 at 1.8A | Descriptor: | Lysine-specific demethylase REF6, ZINC ION | Authors: | Tian, Z, Chen, Z. | Deposit date: | 2018-06-22 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms. Cell Discov, 6, 2020
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6A71
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![BU of 6a71 by Molmil](/molmil-images/mine/6a71) | Crystal Structure of Human ATP7B and TM Complex | Descriptor: | ATP7B protein, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Chen, W.B. | Deposit date: | 2018-06-30 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein. Nat Commun, 10, 2019
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4POT
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![BU of 4pot by Molmil](/molmil-images/mine/4pot) | |