7XPY
Crystal structure of USP7 in complex with its inhibitor
Summary for 7XPY
Entry DOI | 10.2210/pdb7xpy/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, [(3S,3aR,4R,6Z,9S,10E,11aR)-9-acetyloxy-6-(acetyloxymethyl)-3,10-dimethyl-2-oxidanylidene-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-4-yl] (E)-2-methyl-4-oxidanyl-but-2-enoate (3 entities in total) |
Functional Keywords | inhibitor, protein degradation, ubiquitin-specific protease, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 64570.51 |
Authors | Feng, N.,Zeng, K.W. (deposition date: 2022-05-06, release date: 2022-08-24, Last modification date: 2023-11-29) |
Primary citation | Zhang, X.W.,Feng, N.,Liu, Y.C.,Guo, Q.,Wang, J.K.,Bai, Y.Z.,Ye, X.M.,Yang, Z.,Yang, H.,Liu, Y.,Yang, M.M.,Wang, Y.H.,Shi, X.M.,Liu, D.,Tu, P.F.,Zeng, K.W. Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv, 8:eabo0789-eabo0789, 2022 Cited by PubMed: 35947662DOI: 10.1126/sciadv.abo0789 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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