7XPY

Crystal structure of USP7 in complex with its inhibitor

Summary for 7XPY

• Entry DOI: 10.2210/pdb7xpy/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, [(3S,3aR,4R,6Z,9S,10E,11aR)-9-acetyloxy-6-(acetyloxymethyl)-3,10-dimethyl-2-oxidanylidene-3a,4,5,8,9,11a-hexahydro-3H-cyclodeca[b]furan-4-yl] (E)-2-methyl-4-oxidanyl-but-2-enoate (3 entities in total)
• Functional Keywords: inhibitor, protein degradation, ubiquitin-specific protease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 64570.51

Authors

Feng, N.,Zeng, K.W. (deposition date: 2022-05-06, release date: 2022-08-24, Last modification date: 2023-11-29)

• Primary citation: Zhang, X.W.,Feng, N.,Liu, Y.C.,Guo, Q.,Wang, J.K.,Bai, Y.Z.,Ye, X.M.,Yang, Z.,Yang, H.,Liu, Y.,Yang, M.M.,Wang, Y.H.,Shi, X.M.,Liu, D.,Tu, P.F.,Zeng, K.W.; Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy.; Sci Adv, 8:eabo0789-eabo0789, 2022; PubMed: 35947662; DOI: 10.1126/sciadv.abo0789

Experimental method

X-RAY DIFFRACTION (2.35 Å)