8W09
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![BU of 8w09 by Molmil](/molmil-images/mine/8w09) | HIV-1 wild-type intasome core | Descriptor: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ... | Authors: | Li, M, Craigie, R. | Deposit date: | 2024-02-13 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
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8W34
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![BU of 8w34 by Molmil](/molmil-images/mine/8w34) | HIV-1 intasome core assembled with wild-type integrase, 1F | Descriptor: | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (5'-D(*AP*CP*TP*GP*CP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*CP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*GP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*GP*CP*A)-3'), ... | Authors: | Li, M, Craigie, R. | Deposit date: | 2024-02-21 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
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8WXR
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![BU of 8wxr by Molmil](/molmil-images/mine/8wxr) | |
8WXU
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![BU of 8wxu by Molmil](/molmil-images/mine/8wxu) | |
8WXV
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![BU of 8wxv by Molmil](/molmil-images/mine/8wxv) | |
8WXT
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![BU of 8wxt by Molmil](/molmil-images/mine/8wxt) | |
8WXQ
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![BU of 8wxq by Molmil](/molmil-images/mine/8wxq) | Structure of WDR5 in complex with WIN motif containing MBD3C | Descriptor: | GLY-ALA-ALA-ARG-CYS-ARG-VAL-PHE-SER-PRO, WD repeat-containing protein 5 | Authors: | Xu, L, Yang, Y. | Deposit date: | 2023-10-30 | Release date: | 2024-06-26 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural studies of WDR5 in complex with MBD3C WIN motif reveal a unique binding mode. J.Biol.Chem., 300, 2024
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8WXX
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8X0S
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![BU of 8x0s by Molmil](/molmil-images/mine/8x0s) | Crystal structure of r(G4C2)2 | Descriptor: | POTASSIUM ION, RNA (5'-R(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*C)-3') | Authors: | Geng, Y, Liu, C, Cai, Q, Zhu, G. | Deposit date: | 2023-11-05 | Release date: | 2024-06-19 | Last modified: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.956 Å) | Cite: | Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD. Nucleic Acids Res., 52, 2024
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6LQO
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![BU of 6lqo by Molmil](/molmil-images/mine/6lqo) | EBV tegument protein BBRF2/BSRF1 complex | Descriptor: | ACETATE ION, Cytoplasmic envelopment protein 1, GLYCEROL, ... | Authors: | He, H.P, Luo, M, Cao, Y.L, Gao, S. | Deposit date: | 2020-01-14 | Release date: | 2020-10-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.0911262 Å) | Cite: | Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun, 11, 2020
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5X0T
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![BU of 5x0t by Molmil](/molmil-images/mine/5x0t) | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody 6H8 | Descriptor: | 6H8 Fab fragment heavy chain, 6H8 Fab fragment light chain, Basigin | Authors: | Lin, P, Zhang, M.-Y, Ye, S, Chen, X, Yu, X.-L, Zhang, R.-G, Zhu, P, Chen, Z.-N. | Deposit date: | 2017-01-23 | Release date: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of CD147 C2 domain in complex with Fab of its monoclonal antibody To Be Published
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6LQN
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![BU of 6lqn by Molmil](/molmil-images/mine/6lqn) | EBV tegument protein BBRF2 | Descriptor: | Cytoplasmic envelopment protein 1, NITRATE ION, SULFATE ION | Authors: | He, H.P, Luo, M, Cao, Y.L, Gao, S. | Deposit date: | 2020-01-14 | Release date: | 2020-10-07 | Last modified: | 2021-04-21 | Method: | X-RAY DIFFRACTION (1.600022 Å) | Cite: | Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment. Nat Commun, 11, 2020
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7WM0
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![BU of 7wm0 by Molmil](/molmil-images/mine/7wm0) | |
7WLY
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![BU of 7wly by Molmil](/molmil-images/mine/7wly) | Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down- and 2 up RBDs) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, ... | Authors: | Wang, X, Zhu, Y. | Deposit date: | 2022-01-14 | Release date: | 2022-05-25 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | 35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope. Cell Host Microbe, 30, 2022
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7WLZ
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![BU of 7wlz by Molmil](/molmil-images/mine/7wlz) | |
8KB0
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![BU of 8kb0 by Molmil](/molmil-images/mine/8kb0) | Crystal structure of 01JD-AEAIIVAMV | Descriptor: | Beta2-microglobulin, MHC class I antigen alpha chain, peptide of AIV | Authors: | Tang, Z, Zhang, N. | Deposit date: | 2023-08-03 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The impact of micropolymorphism in Anpl-UAA on structural stability and peptide presentation. Int.J.Biol.Macromol., 267, 2024
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8KB1
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![BU of 8kb1 by Molmil](/molmil-images/mine/8kb1) | Crystal structure of 11JD | Descriptor: | Beta2-microglobulin, MHC class I antigen, peptide of AIV | Authors: | Tang, Z, Zhang, N. | Deposit date: | 2023-08-03 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | The impact of micropolymorphism in Anpl-UAA on structural stability and peptide presentation. Int.J.Biol.Macromol., 267, 2024
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3HYF
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![BU of 3hyf by Molmil](/molmil-images/mine/3hyf) | Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor | Descriptor: | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ... | Authors: | Lansdon, E.B, Kirschberg, T.A. | Deposit date: | 2009-06-22 | Release date: | 2009-10-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J.Med.Chem., 52, 2009
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7VJL
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![BU of 7vjl by Molmil](/molmil-images/mine/7vjl) | The crystal structure of FGFR4 kinase domain in complex with N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-(2,2,2-trifluoroacetyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide | Descriptor: | Fibroblast growth factor receptor 4, N-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | Authors: | Zhang, Z.M, Wang, Y.J. | Deposit date: | 2021-09-28 | Release date: | 2022-02-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.900173 Å) | Cite: | Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg.Med.Chem., 50, 2021
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7WCL
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![BU of 7wcl by Molmil](/molmil-images/mine/7wcl) | Crystal structure of FGFR1 kinase domain with Pemigatinib | Descriptor: | 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one, Fibroblast growth factor receptor 1, SULFATE ION | Authors: | Chen, X.J, Lin, Q.M, Jiang, L.Y, Qu, L.Z, Chen, Y.H. | Deposit date: | 2021-12-20 | Release date: | 2022-09-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.495 Å) | Cite: | Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants. Commun Chem, 5, 2022
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8HPB
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8HQB
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![BU of 8hqb by Molmil](/molmil-images/mine/8hqb) | NMR Structure of OsCIE1-Ubox | Descriptor: | U-box domain-containing protein 12 | Authors: | Zhang, Y, Yu, C.Z, Lan, W.X. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Last modified: | 2024-06-12 | Method: | SOLUTION NMR | Cite: | Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice. Nature, 629, 2024
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6J1Z
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![BU of 6j1z by Molmil](/molmil-images/mine/6j1z) | WWP2 semi-open conformation | Descriptor: | NEDD4-like E3 ubiquitin-protein ligase WWP2 | Authors: | Liu, Z.H. | Deposit date: | 2018-12-30 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases. Nat Commun, 10, 2019
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8HZJ
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![BU of 8hzj by Molmil](/molmil-images/mine/8hzj) | A new fluorescent RNA aptamer bound with N571 | Descriptor: | (5~{Z})-5-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]methylidene]-3-methyl-2-[(~{E})-2-phenylethenyl]imidazol-4-one, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Huang, K.Y, Ren, A.M. | Deposit date: | 2023-01-09 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat.Chem.Biol., 2024
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8HZD
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![BU of 8hzd by Molmil](/molmil-images/mine/8hzd) | A new fluorescent RNA aptamer bound with N618 | Descriptor: | 4-[(~{E})-2-[(4~{Z})-4-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]methylidene]-1-methyl-5-oxidanylidene-imidazol-2-yl]ethenyl]benzenecarbonitrile, MAGNESIUM ION, RNA (36-MER) | Authors: | Song, Q.Q, Ren, A.M. | Deposit date: | 2023-01-09 | Release date: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat.Chem.Biol., 2024
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