5D6L
| beta2AR-T4L - CIM | Descriptor: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ... | Authors: | Ma, P, Caffrey, M. | Deposit date: | 2015-08-12 | Release date: | 2016-08-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The cubicon method for concentrating membrane proteins in the cubic mesophase. Nat Protoc, 12, 2017
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6YBQ
| Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA | Descriptor: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | Authors: | Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J. | Deposit date: | 2020-03-17 | Release date: | 2020-10-28 | Last modified: | 2021-05-12 | Method: | ELECTRON MICROSCOPY (1.96 Å) | Cite: | A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation Nat Catal, 2021
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8B0N
| Cryo-EM structure of apolipoprotein N-acyltransferase Lnt from E. coli in complex with Lyso-PE | Descriptor: | Apolipoprotein N-acyltransferase, [(2~{S})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-oxidanyl-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Degtjarik, O, Smithers, L, Boland, C, Caffrey, M, Shalev Benami, M. | Deposit date: | 2022-09-07 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N -acyltransferase. Sci Adv, 9, 2023
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6RSN
| SOSEKI polymerising domain (SOK4 D85A mutant) | Descriptor: | SULFATE ION, UPSTREAM OF FLC-like protein (DUF966) | Authors: | Fiedler, M, Bienz, M. | Deposit date: | 2019-05-21 | Release date: | 2020-01-29 | Last modified: | 2020-02-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes. Cell, 180, 2020
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6UDK
| HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 | Descriptor: | 1-55 Fab Heavy Chain, 1-55 Fab Light Chain, 10-1074 Fab Heavy Chain, ... | Authors: | Abernathy, M.E, Barnes, C.O, Gristick, H.B, Bjorkman, P.J. | Deposit date: | 2019-09-19 | Release date: | 2020-01-29 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180, 2020
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6UDJ
| HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 | Descriptor: | 1-18 Fab Heavy Chain, 1-18 Fab Light Chain, 10-1074 Fab Heavy Chain, ... | Authors: | Abernathy, M.E, Barnes, C.O, Gristick, H.B, Bjorkman, P.J. | Deposit date: | 2019-09-19 | Release date: | 2020-01-29 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180, 2020
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4BHK
| Crystal Structure of Moss Leafy bound to DNA | Descriptor: | FLORICAULA/LEAFY HOMOLOG 1, MOSS-CR54 DNA | Authors: | Nanao, M.H, Sayou, C, Dumas, R, Parcy, F. | Deposit date: | 2013-04-03 | Release date: | 2014-01-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | A Promiscuous Intermediate Underlies the Evolution of Leafy DNA Binding Specificity. Science, 343, 2014
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4LDW
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7W6P
| Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist | Descriptor: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | Deposit date: | 2021-12-02 | Release date: | 2022-09-28 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
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7W7E
| Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist | Descriptor: | 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | Deposit date: | 2021-12-04 | Release date: | 2022-09-28 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
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7EJK
| Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline | Descriptor: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, J, Cao, S, Liu, Z, Du, Y. | Deposit date: | 2021-04-02 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7EJ0
| Structure of the alpha2A-adrenergic receptor GoA signaling complex | Descriptor: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, J, Cao, S, Liu, Z, Du, Y. | Deposit date: | 2021-04-01 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7EJA
| Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine | Descriptor: | 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Cao, S, Liu, Z, Du, Y. | Deposit date: | 2021-04-01 | Release date: | 2022-04-13 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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7EJ8
| Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine | Descriptor: | Alpha-2A adrenergic receptor, Brimonidine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Cao, S, Liu, Z, Du, Y. | Deposit date: | 2021-04-01 | Release date: | 2022-04-13 | Last modified: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor. Sci Adv, 8, 2022
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3D0E
| Crystal structure of human Akt2 in complex with GSK690693 | Descriptor: | 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3-yn-2-ol, RAC-beta serine/threonine-protein kinase | Authors: | Concha, N.O, Smallwood, A. | Deposit date: | 2008-05-01 | Release date: | 2008-10-21 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem., 51, 2008
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3SHI
| Crystal structure of human MMP1 catalytic domain at 2.2 A resolution | Descriptor: | CALCIUM ION, Interstitial collagenase, ZINC ION | Authors: | Bertini, I, Calderone, V, Cerofolini, L, Fragai, M, Geraldes, C.F.G.C, Hermann, P, Luchinat, C, Parigi, G, Teixeira, J. | Deposit date: | 2011-06-16 | Release date: | 2011-09-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The catalytic domain of MMP-1 studied through tagged lanthanides. Febs Lett., 586, 2012
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