3D0E

Crystal structure of human Akt2 in complex with GSK690693

Summary for 3D0E

• Entry DOI: 10.2210/pdb3d0e/pdb
• Descriptor: RAC-beta serine/threonine-protein kinase, 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3-yn-2-ol (3 entities in total)
• Functional Keywords: human, akt2, inhibitor, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transferase inhibitor
• Biological source: Homo sapiens
• Cellular location: Cytoplasm: P31751
• Total number of polymer chains: 2
• Total formula weight: 78995.99

Authors

Concha, N.O.,Smallwood, A. (deposition date: 2008-05-01, release date: 2008-10-21, Last modification date: 2017-10-25)

• Primary citation: Heerding, D.A.,Rhodes, N.,Leber, J.D.,Clark, T.J.,Keenan, R.M.,Lafrance, L.V.,Li, M.,Safonov, I.G.,Takata, D.T.,Venslavsky, J.W.,Yamashita, D.S.,Choudhry, A.E.,Copeland, R.A.,Lai, Z.,Schaber, M.D.,Tummino, P.J.,Strum, S.L.,Wood, E.R.,Duckett, D.R.,Eberwein, D.,Knick, V.B.,Lansing, T.J.,McConnell, R.T.,Zhang, S.,Minthorn, E.A.,Concha, N.O.,Warren, G.L.,Kumar, R.; Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.; J.Med.Chem., 51:5663-5679, 2008; PubMed: 18800763; DOI: 10.1021/jm8004527

Experimental method

X-RAY DIFFRACTION (2 Å)