3D0E
Crystal structure of human Akt2 in complex with GSK690693
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RAC-beta serine/threonine-protein kinase | polymer | 335 | 39072.5 | 2 | UniProt (P31751) Pfam (PF00069) Pfam (PF00433) | Homo sapiens | RAC-PK-beta, Protein kinase Akt-2, Protein kinase B, beta, PKB beta |
| 2 | C, D (A, B) | 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3 -yn-2-ol | non-polymer | 425.5 | 2 | Chemie (G93) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 450 | Chemie (HOH) |
Sequence modifications
A, B: 146 - 480 (UniProt: P31751)
| PDB | External Database | Details |
|---|---|---|
| Asp 474 | Ser 474 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78145.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 851.0 | |
| All* | Total formula weight | 78996.0 |
