4BHK
Crystal Structure of Moss Leafy bound to DNA
Summary for 4BHK
| Entry DOI | 10.2210/pdb4bhk/pdb |
| Descriptor | FLORICAULA/LEAFY HOMOLOG 1, MOSS-CR54 DNA, ... (4 entities in total) |
| Functional Keywords | transcription-dna complex, transcription/dna |
| Biological source | PHYSCOMITRELLA PATENS More |
| Total number of polymer chains | 4 |
| Total formula weight | 57880.11 |
| Authors | Nanao, M.H.,Sayou, C.,Dumas, R.,Parcy, F. (deposition date: 2013-04-03, release date: 2014-01-22, Last modification date: 2023-12-20) |
| Primary citation | Sayou, C.,Monniaux, M.,Nanao, M.H.,Moyroud, E.,Brockington, S.F.,Thevenon, E.,Chahtane, H.,Warthmann, N.,Melkonian, M.,Zhang, Y.,Wong, G.K.,Weigel, D.,Parcy, F.,Dumas, R. A Promiscuous Intermediate Underlies the Evolution of Leafy DNA Binding Specificity. Science, 343:645-, 2014 Cited by PubMed Abstract: Transcription factors (TFs) are key players in evolution. Changes affecting their function can yield novel life forms but may also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which TFs acquire new activities. Here, we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of the LEAFY gene. We examined how these changes occurred at the structural level and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions, thereby allowing LEAFY to evolve new binding specificities while remaining a single-copy gene. PubMed: 24436181DOI: 10.1126/SCIENCE.1248229 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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