7AK0
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![BU of 7ak0 by Molmil](/molmil-images/mine/7ak0) | Human MALT1(329-729) in complex with a chromane urea containing inhibitor | Descriptor: | 1-[4-[4-(aminomethyl)pyrazol-1-yl]-3-chloranyl-phenyl]-3-[(3~{R})-6-bromanyl-3,4-dihydro-2~{H}-chromen-3-yl]urea, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M. | Deposit date: | 2020-09-29 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.316 Å) | Cite: | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. J.Med.Chem., 63, 2020
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7AK1
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![BU of 7ak1 by Molmil](/molmil-images/mine/7ak1) | Human MALT1(329-729) in complex with a chromane urea containing inhibitor | Descriptor: | 1-(3-chloranyl-4-methoxy-phenyl)-3-[7-[(3~{S})-3-(methoxymethyl)morpholin-4-yl]-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]urea, MAGNESIUM ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Authors: | Renatus, M. | Deposit date: | 2020-09-29 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. J.Med.Chem., 63, 2020
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6SAK
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![BU of 6sak by Molmil](/molmil-images/mine/6sak) | |
8FEF
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![BU of 8fef by Molmil](/molmil-images/mine/8fef) | Structure of Mce1 transporter from Mycobacterium smegmatis (Map0) | Descriptor: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | Authors: | Chen, J, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-12-06 | Release date: | 2023-02-22 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structure of an endogenous mycobacterial MCE lipid transporter. Nature, 620, 2023
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8FED
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![BU of 8fed by Molmil](/molmil-images/mine/8fed) | Structure of Mce1-LucB complex from Mycobacterium smegmatis (Map1) | Descriptor: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | Authors: | Chen, J, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-12-06 | Release date: | 2023-02-22 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Structure of an endogenous mycobacterial MCE lipid transporter. Nature, 620, 2023
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8FEE
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![BU of 8fee by Molmil](/molmil-images/mine/8fee) | Structure of Mce1 transporter from Mycobacterium smegmatis in the absence of LucB (Map2) | Descriptor: | ABC transporter, ATP-binding protein,Green fluorescent protein chimera, ABC-transporter integral membrane protein, ... | Authors: | Chen, J, Bhabha, G, Ekiert, D.C. | Deposit date: | 2022-12-06 | Release date: | 2023-02-22 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of an endogenous mycobacterial MCE lipid transporter. Nature, 620, 2023
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3Q2V
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![BU of 3q2v by Molmil](/molmil-images/mine/3q2v) | Crystal structure of mouse E-cadherin ectodomain | Descriptor: | CALCIUM ION, Cadherin-1, MANGANESE (II) ION, ... | Authors: | Jin, X, Harrison, O.J, Shapiro, L. | Deposit date: | 2010-12-20 | Release date: | 2011-04-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19, 2011
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3Q2W
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![BU of 3q2w by Molmil](/molmil-images/mine/3q2w) | Crystal structure of mouse N-cadherin ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Jin, X, Shapiro, L. | Deposit date: | 2010-12-20 | Release date: | 2011-02-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19, 2011
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3Q2L
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![BU of 3q2l by Molmil](/molmil-images/mine/3q2l) | Mouse E-cadherin EC1-2 V81D mutant | Descriptor: | CALCIUM ION, Cadherin-1, PENTAETHYLENE GLYCOL | Authors: | Harrison, O.J, Jin, X, Shapiro, L. | Deposit date: | 2010-12-20 | Release date: | 2011-02-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19, 2011
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3Q2N
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![BU of 3q2n by Molmil](/molmil-images/mine/3q2n) | Mouse E-cadherin EC1-2 L175D mutant | Descriptor: | CALCIUM ION, Cadherin-1, TETRAETHYLENE GLYCOL | Authors: | Harrison, O.J, Jin, X, Shapiro, L. | Deposit date: | 2010-12-20 | Release date: | 2011-02-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure, 19, 2011
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1W3Y
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![BU of 1w3y by Molmil](/molmil-images/mine/1w3y) | Crystal structure of S. pneumoniae hyaluronate lyase in complex with palmitoyl-vitamin C | Descriptor: | (2E,4R,5S)-2,3,4,5-TETRAHYDROXY-6-(PALMITOYLOXY)HEX-2-ENOIC ACID, HYALURONATE LYASE, SULFATE ION, ... | Authors: | Rigden, D.J, Jedrzejas, M.J. | Deposit date: | 2004-07-21 | Release date: | 2004-08-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-Ray Structure and Molecular Modeling of Enzyme-Inhibitor Complexes J.Biol.Chem., 279, 2004
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3OOZ
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![BU of 3ooz by Molmil](/molmil-images/mine/3ooz) | Bace1 in complex with the aminohydantoin Compound 102 | Descriptor: | (5R)-2-amino-5-[4-(difluoromethoxy)phenyl]-5-[4-fluoro-3-(5-fluoropent-1-yn-1-yl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Beta-secretase 1 | Authors: | Olland, A.M. | Deposit date: | 2010-08-31 | Release date: | 2011-08-31 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design and Synthesis of Aminohydantoins as Potent and Selective Human beta-Secretase (BACE1) Inhibitors with Enhanced Brain Permeability Bioorg.Med.Chem.Lett., 20, 2010
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8BEC
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![BU of 8bec by Molmil](/molmil-images/mine/8bec) | Crystal structure of the SARS-CoV-2 S RBD in complex with pT1375 scFV | Descriptor: | SULFATE ION, Spike protein S1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hansen, G, Ssebyatika, G.L, Krey, T. | Deposit date: | 2022-10-21 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published
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8BG1
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![BU of 8bg1 by Molmil](/molmil-images/mine/8bg1) | Crystal structure of the SARS-CoV-2 S RBD in complex with pT1511 scFV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Hansen, G, Ssebyatika, G.L, Krey, T. | Deposit date: | 2022-10-27 | Release date: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published
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8BG2
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![BU of 8bg2 by Molmil](/molmil-images/mine/8bg2) | |
8BG3
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![BU of 8bg3 by Molmil](/molmil-images/mine/8bg3) | |
8BG5
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![BU of 8bg5 by Molmil](/molmil-images/mine/8bg5) | |
8BG4
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![BU of 8bg4 by Molmil](/molmil-images/mine/8bg4) | |
8BG6
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![BU of 8bg6 by Molmil](/molmil-images/mine/8bg6) | SARS-CoV-2 S protein in complex with pT1644 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1644 Fab heavy chain, ... | Authors: | Stroeh, L, Hansen, G, Vollmer, B, Krey, T, Benecke, T, Gruenewald, K. | Deposit date: | 2022-10-27 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published
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8BG8
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![BU of 8bg8 by Molmil](/molmil-images/mine/8bg8) | SARS-CoV-2 S protein in complex with pT1696 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1696 Fab heavy chain, ... | Authors: | Hansen, G, Benecke, T, Vollmer, B, Gruenewald, K, Krey, T. | Deposit date: | 2022-10-27 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses? To be published
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7A0N
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![BU of 7a0n by Molmil](/molmil-images/mine/7a0n) | Structure of TSC1 NTD and linker domain | Descriptor: | Uncharacterized protein,Uncharacterized protein | Authors: | Fitzian, K, Kuemmel, D. | Deposit date: | 2020-08-10 | Release date: | 2021-05-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol.Cell, 81, 2021
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7A0M
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![BU of 7a0m by Molmil](/molmil-images/mine/7a0m) | TSC1 N-terminal domain | Descriptor: | SULFATE ION, TSC1 N-terminal domain | Authors: | Zech, R, Kiontke, S, Kuemmel, D. | Deposit date: | 2020-08-10 | Release date: | 2021-05-26 | Last modified: | 2021-07-14 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation. Mol.Cell, 81, 2021
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6SSH
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![BU of 6ssh by Molmil](/molmil-images/mine/6ssh) | Structure of the TSC2 GAP domain | Descriptor: | 1,2-ETHANEDIOL, GTPase activator-like protein | Authors: | Hansmann, P, Kiontke, S, Kummel, D. | Deposit date: | 2019-09-06 | Release date: | 2020-05-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Structure, 28, 2020
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2MMM
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![BU of 2mmm by Molmil](/molmil-images/mine/2mmm) | |
3S7L
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![BU of 3s7l by Molmil](/molmil-images/mine/3s7l) | |