8P9X

Vitamin D receptor complex with Xe4Me agonist ligand

Summary for 8P9X

Entry DOI	10.2210/pdb8p9x/pdb
Descriptor	Vitamin D3 receptor A, Nuclear receptor coactivator 2, ACETATE ION, ... (5 entities in total)
Functional Keywords	nuclear receptor, agonist, ligand binding domain, transcription
Biological source	Danio rerio (zebrafish) More
Total number of polymer chains	2
Total formula weight	36108.15
Authors	Rochel, N. (deposition date: 2023-06-06, release date: 2024-06-26, Last modification date: 2024-10-16)
Primary citation	Len-Tayon, K.,Beraud, C.,Fauveau, C.,Belorusova, A.Y.,Chebaro, Y.,Mourino, A.,Massfelder, T.,Chauchereau, A.,Metzger, D.,Rochel, N.,Laverny, G. A vitamin D-based strategy overcomes chemoresistance in prostate cancer. Br.J.Pharmacol., 181:4279-4293, 2024 Cited by PubMed Abstract: Castration-resistant prostate cancer (CRPC) is a common male malignancy that requires new therapeutic strategies due to acquired resistance to its first-line treatment, docetaxel. The benefits of vitamin D on prostate cancer (PCa) progression have been previously reported. This study aimed to investigate the effects of vitamin D on chemoresistance in CRPC. PubMed: 38982588 DOI: 10.1111/bph.16492 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation