300D
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![BU of 300d by Molmil](/molmil-images/mine/300d) | CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MN(II)-SOAKED | Descriptor: | MANGANESE (II) ION, RNA HAMMERHEAD RIBOZYME | Authors: | Scott, W.G, Murray, J.B, Arnold, J.R.P, Stoddard, B.L, Klug, A. | Deposit date: | 1996-12-14 | Release date: | 1997-01-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme. Science, 274, 1996
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3C25
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![BU of 3c25 by Molmil](/molmil-images/mine/3c25) | Crystal Structure of NotI Restriction Endonuclease Bound to Cognate DNA | Descriptor: | CALCIUM ION, DNA (5'-D(*DCP*DGP*DGP*DAP*DGP*DGP*DCP*DGP*DCP*DGP*DGP*DCP*DCP*DGP*DCP*DGP*DCP*DCP*DGP*DCP*DCP*DG)-3'), DNA (5'-D(*DCP*DGP*DGP*DCP*DGP*DGP*DCP*DGP*DCP*DGP*DGP*DCP*DCP*DGP*DCP*DGP*DCP*DCP*DTP*DCP*DCP*DG)-3'), ... | Authors: | Lambert, A.R, Sussman, D, Shen, B, Stoddard, B.L. | Deposit date: | 2008-01-24 | Release date: | 2008-02-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures of the Rare-Cutting Restriction Endonuclease NotI Reveal a Unique Metal Binding Fold Involved in DNA Binding. Structure, 16, 2008
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7SQ4
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![BU of 7sq4 by Molmil](/molmil-images/mine/7sq4) | Designed trefoil knot protein, variant 2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Designed trefoil knot protein, variant 2, ... | Authors: | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | Deposit date: | 2021-11-04 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.493 Å) | Cite: | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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7SQ3
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![BU of 7sq3 by Molmil](/molmil-images/mine/7sq3) | Designed trefoil knot protein, variant 1 | Descriptor: | CHLORIDE ION, Designed trefoil knot protein, variant 1, ... | Authors: | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | Deposit date: | 2021-11-04 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.453 Å) | Cite: | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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7SQ5
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![BU of 7sq5 by Molmil](/molmil-images/mine/7sq5) | Designed trefoil knot protein, variant 3 | Descriptor: | Designed trefoil knot protein, variant 3, SODIUM ION | Authors: | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | Deposit date: | 2021-11-04 | Release date: | 2022-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.205 Å) | Cite: | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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5JSB
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![BU of 5jsb by Molmil](/molmil-images/mine/5jsb) | Crystal structure of Mcl1-inhibitor complex | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2016-05-07 | Release date: | 2016-11-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
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5ESP
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![BU of 5esp by Molmil](/molmil-images/mine/5esp) | |
8E0N
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![BU of 8e0n by Molmil](/molmil-images/mine/8e0n) | |
8E0O
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![BU of 8e0o by Molmil](/molmil-images/mine/8e0o) | |
8E0M
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![BU of 8e0m by Molmil](/molmil-images/mine/8e0m) | |
8E12
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![BU of 8e12 by Molmil](/molmil-images/mine/8e12) | |
8E0L
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![BU of 8e0l by Molmil](/molmil-images/mine/8e0l) | |
6UVW
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![BU of 6uvw by Molmil](/molmil-images/mine/6uvw) | |
6UWK
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![BU of 6uwk by Molmil](/molmil-images/mine/6uwk) | |
6UWJ
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![BU of 6uwj by Molmil](/molmil-images/mine/6uwj) | |
6UWH
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![BU of 6uwh by Molmil](/molmil-images/mine/6uwh) | |
6UWG
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![BU of 6uwg by Molmil](/molmil-images/mine/6uwg) | |
6UW0
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![BU of 6uw0 by Molmil](/molmil-images/mine/6uw0) | |
3U0S
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![BU of 3u0s by Molmil](/molmil-images/mine/3u0s) | Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Diisopropyl-fluorophosphatase, GLYCEROL, ... | Authors: | Bale, J.B, Shen, B.W, Stoddard, B.L. | Deposit date: | 2011-09-29 | Release date: | 2012-02-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nat.Biotechnol., 30, 2012
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1IDE
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![BU of 1ide by Molmil](/molmil-images/mine/1ide) | ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION) | Descriptor: | ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION, ... | Authors: | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | Deposit date: | 1995-01-18 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase. Science, 268, 1995
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1P6O
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![BU of 1p6o by Molmil](/molmil-images/mine/1p6o) | The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms. | Descriptor: | 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, ACETIC ACID, CALCIUM ION, ... | Authors: | Ireton, G.C, Black, M.E, Stoddard, B.L. | Deposit date: | 2003-04-29 | Release date: | 2003-08-19 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure, 11, 2003
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1N3F
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![BU of 1n3f by Molmil](/molmil-images/mine/1n3f) | Crystal structure of I-CreI bound to a palindromic DNA sequence II (palindrome of right side of wildtype DNA target sequence) | Descriptor: | 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G-3'), CALCIUM ION, ... | Authors: | Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L. | Deposit date: | 2002-10-28 | Release date: | 2003-06-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI J.Mol.Biol., 329, 2003
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1N3E
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![BU of 1n3e by Molmil](/molmil-images/mine/1n3e) | Crystal structure of I-CreI bound to a palindromic DNA sequence I (palindrome of left side of wildtype DNA target sequence) | Descriptor: | 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3', 5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... | Authors: | Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L. | Deposit date: | 2002-10-28 | Release date: | 2003-06-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI J.Mol.Biol., 329, 2003
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1MOW
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![BU of 1mow by Molmil](/molmil-images/mine/1mow) | E-DreI | Descriptor: | 5'-D(*CP*CP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*AP*GP*TP*TP*CP*CP*GP*GP*CP*G)-3', 5'-D(*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*GP*G)-3', GLYCEROL, ... | Authors: | Chevalier, B.S, Kortemme, T, Chadsey, M.S, Baker, D, Monnat Jr, R.J, Stoddard, B.L. | Deposit date: | 2002-09-10 | Release date: | 2002-11-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design, Activity and Structure of a Highly Specific Artificial Endonuclease Mol.Cell, 10, 2002
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1OX7
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![BU of 1ox7 by Molmil](/molmil-images/mine/1ox7) | |