1P6O

The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.

Summary for 1P6O

Related1OX7
DescriptorCytosine deaminase, ZINC ION, 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, ... (6 entities in total)
Functional Keywordscytosine deaminase, hydrolase, dimer, inhibitor bound
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Total number of polymer chains2
Total molecular weight36141.79
Authors
Ireton, G.C.,Black, M.E.,Stoddard, B.L. (deposition date: 2003-04-29, release date: 2003-08-19, Last modification date: 2011-07-13)
Primary citation
Ireton, G.C.,Black, M.E.,Stoddard, B.L.
The 1.14 a crystal structure of yeast Cytosine deaminase. Evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.
Structure, 11:961-972, 2003
PubMed: 12906827 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(03)00153-9
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.14 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.117601.5%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution