4G0O
| Crystal structure of Arabidopsis thaliana AGO5 MID domain | Descriptor: | Protein argonaute 5, SULFATE ION | Authors: | Frank, F, Hauver, J, Sonenberg, N, Nagar, B. | Deposit date: | 2012-07-09 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.186 Å) | Cite: | Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. Embo J., 31, 2012
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4G0M
| Crystal structure of Arabidopsis thaliana AGO2 MID domain | Descriptor: | Protein argonaute 2, SULFATE ION | Authors: | Frank, F, Hauver, J, Sonenberg, N, Nagar, B. | Deposit date: | 2012-07-09 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.306 Å) | Cite: | Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. Embo J., 31, 2012
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4G0Q
| Crystal structure of Arabidopsis thaliana AGO1 MID domain in complex with CMP | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, Protein argonaute 1 | Authors: | Frank, F, Hauver, J, Sonenberg, N, Nagar, B. | Deposit date: | 2012-07-09 | Release date: | 2012-07-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. Embo J., 31, 2012
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4HOR
| Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligocytidine | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 5, MAGNESIUM ION, RNA (5'-R(*(CTP)P*CP*CP*CP*C)-3') | Authors: | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | Deposit date: | 2012-10-22 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.861 Å) | Cite: | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOU
| Crystal Structure of N-terminal Human IFIT1 | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 1 | Authors: | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | Deposit date: | 2012-10-22 | Release date: | 2013-01-30 | Last modified: | 2013-02-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOT
| Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligoadenine | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 5, MAGNESIUM ION, RNA (5'-R(*(ATP)P*AP*AP*A)-3') | Authors: | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | Deposit date: | 2012-10-22 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOQ
| Crystal Structure of Full-Length Human IFIT5 | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 5 | Authors: | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | Deposit date: | 2012-10-22 | Release date: | 2013-01-23 | Last modified: | 2013-02-27 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOS
| Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 5, RNA (5'-R(*(UTP)P*UP*UP*U)-3'), SODIUM ION | Authors: | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | Deposit date: | 2012-10-22 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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5UDJ
| IFIT1 monomeric mutant (L457E/L464E) with Gppp-AAAA | Descriptor: | CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(G3A))-R(P*AP*AP*A)-3'), ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U85
| Murine saposin-D (SapD), open conformation | Descriptor: | Saposin-D | Authors: | Gebai, A, Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2016-12-13 | Release date: | 2018-06-13 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of saposin D in an open conformation. J. Struct. Biol., 204, 2018
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5U84
| Acid ceramidase (ASAH1, aCDase) from common minke whale, Cys143Ala, uncleaved | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, ... | Authors: | Gebai, A, Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2016-12-13 | Release date: | 2018-03-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural basis for the activation of acid ceramidase. Nat Commun, 9, 2018
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5U7Z
| Human acid ceramidase (ASAH1, aCDase) self-activated | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid ceramidase, SULFATE ION, ... | Authors: | Gebai, A, Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2016-12-13 | Release date: | 2018-03-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the activation of acid ceramidase. Nat Commun, 9, 2018
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5UDL
| IFIT1 N216A monomeric mutant (L457E/L464E) with m7Gppp-AAAA (anti conformation of cap) | Descriptor: | CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3'), ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UDY
| Human alkaline sphingomyelinase (alk-SMase, ENPP7, NPP7) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Liu, F, Illes, K, Nagar, B. | Deposit date: | 2016-12-28 | Release date: | 2017-03-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition. J. Biol. Chem., 292, 2017
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5VEM
| Human ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ectonucleotide pyrophosphatase/phosphodiesterase family member 5, ... | Authors: | Gorelik, A, Randriamihaja, A, Illes, K, Nagar, B. | Deposit date: | 2017-04-05 | Release date: | 2017-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5. FEBS J., 284, 2017
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5UDK
| IFIT1 monomeric mutant (L457E/L464E) with PPP-AAAA | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U81
| Acid ceramidase (ASAH1, aCDase) from naked mole rat, Cys143Ala, uncleaved | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid ceramidase isoform b, CHLORIDE ION, ... | Authors: | Gebai, A, Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2016-12-13 | Release date: | 2018-03-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis for the activation of acid ceramidase. Nat Commun, 9, 2018
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5VEN
| Murine ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ectonucleotide pyrophosphatase/phosphodiesterase family member 5, ... | Authors: | Gorelik, A, Randriamihaja, A, Illes, K, Nagar, B. | Deposit date: | 2017-04-05 | Release date: | 2017-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5. FEBS J., 284, 2017
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5VEO
| Murine ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5), inactive (T72A), in complex with AMP | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE MONOPHOSPHATE, ... | Authors: | Gorelik, A, Randriamihaja, A, Illes, K, Nagar, B. | Deposit date: | 2017-04-05 | Release date: | 2017-09-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5. FEBS J., 284, 2017
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5W5H
| Human IFIT1 dimer with m7Gppp-AAAA | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3') | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2017-06-15 | Release date: | 2017-07-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding To Be Published
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5W7E
| Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with dimyristoyl phosphatidylcholine | Descriptor: | (2S)-3-hydroxypropane-1,2-diyl ditetradecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acyloxyacyl hydrolase, ... | Authors: | Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2017-06-19 | Release date: | 2018-01-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5W78
| Human acyloxyacyl hydrolase (AOAH), proteolytically processed | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acyloxyacyl hydrolase, CALCIUM ION, ... | Authors: | Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2017-06-19 | Release date: | 2018-01-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.271 Å) | Cite: | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5W7A
| Rabbit acyloxyacyl hydrolase (AOAH), proteolytically processed, S262A mutant, with LPS (low quality saposin domain) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-HYDROXY-TETRADECANOIC ACID, ... | Authors: | Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2017-06-19 | Release date: | 2018-01-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5W7D
| Murine acyloxyacyl hydrolase (AOAH), S262A mutant | Descriptor: | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Nagar, B. | Deposit date: | 2017-06-19 | Release date: | 2018-01-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5UDI
| IFIT1 monomeric mutant (L457E/L464E) with m7Gppp-AAAA (syn and anti conformations of cap) | Descriptor: | CALCIUM ION, Interferon-induced protein with tetratricopeptide repeats 1, RNA (5'-D(*(GTA))-R(P*AP*AP*A)-3'), ... | Authors: | Abbas, Y.M, Martinez-Montero, S, Damha, M.J, Nagar, B. | Deposit date: | 2016-12-27 | Release date: | 2017-03-01 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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