2GP5
| Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, FE (II) ION, Jumonji domain-containing protein 2A, ... | Authors: | Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G. | Deposit date: | 2006-04-16 | Release date: | 2006-05-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006
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2GP3
| Crystal structure of the catalytic core domain of jmjd2a | Descriptor: | FE (II) ION, Jumonji domain-containing protein 2A, ZINC ION | Authors: | Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G. | Deposit date: | 2006-04-16 | Release date: | 2006-05-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural insights into histone demethylation by JMJD2 family members Cell(Cambridge,Mass.), 125, 2006
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7TV0
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7TUQ
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6MIU
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6MJ7
| Crystal structure of p62 ZZ domain in complex with free arginine | Descriptor: | 1,4-DIETHYLENE DIOXIDE, ARGININE, Sequestosome-1, ... | Authors: | Ahn, J, Zhang, Y, Kutateladze, T.G. | Deposit date: | 2018-09-20 | Release date: | 2018-10-31 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.412 Å) | Cite: | ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nat Commun, 9, 2018
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6O1E
| The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP | Descriptor: | MAGNESIUM ION, MORC family CW-type zinc finger protein 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Klein, B.J, Zhang, Y, Kutateladze, T.G. | Deposit date: | 2019-02-19 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Mechanism for autoinhibition and activation of the MORC3 ATPase. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7W9V
| Cryo-EM structure of nucleosome in complex with p300 acetyltransferase catalytic core (complex I) | Descriptor: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | Authors: | Hatazawa, S, Liu, J, Takizawa, Y, Zandian, M, Negishi, L, Kutateladze, T.G, Kurumizaka, H. | Deposit date: | 2021-12-10 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structural basis for binding diversity of acetyltransferase p300 to the nucleosome. Iscience, 25, 2022
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5TDR
| Set3 PHD finger in complex with histone H3K4me2 | Descriptor: | Histone H3, SET domain-containing protein 3, SODIUM ION, ... | Authors: | Andrews, F.H, Ali, M, Kutateladze, T.G. | Deposit date: | 2016-09-19 | Release date: | 2016-11-02 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J. Mol. Biol., 429, 2017
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5U28
| BRD4 first bromodomain (BD1) in complex with dual PI3 kinase inhibitor SF2523 | Descriptor: | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4, DI(HYDROXYETHYL)ETHER, ... | Authors: | Andrews, F.H, Kutateladze, T.G. | Deposit date: | 2016-11-30 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U2C
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5U2J
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5U2E
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5U2F
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5TAB
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5SVX
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5SVY
| MORC3 CW in complex with histone H3K4me1 | Descriptor: | ACETATE ION, H3K4me1, MORC family CW-type zinc finger protein 3, ... | Authors: | Tong, Q, Andrews, F.H, Kutateladze, T.G. | Deposit date: | 2016-08-08 | Release date: | 2016-10-05 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Cell Rep, 16, 2016
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5SVI
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5TDW
| Set3 PHD finger in complex with histone H3K4me3 | Descriptor: | SET domain-containing protein 3, SODIUM ION, ZINC ION, ... | Authors: | Andrews, F.H, Ali, M, Kutateladze, T.G. | Deposit date: | 2016-09-19 | Release date: | 2016-10-19 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J. Mol. Biol., 429, 2017
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9ATN
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8F5Q
| Crystal structure of human PCNA in complex with the PIP box of FBH1 | Descriptor: | F-box DNA helicase 1, Proliferating cell nuclear antigen | Authors: | Liu, J, Chaves-Arquero, B, Wei, P, Tencer, H, Zhang, G, Blanco, F, Kutateladze, T. | Deposit date: | 2022-11-15 | Release date: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular insight into the PCNA-binding mode of FBH1. Structure, 31, 2023
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3OQ5
| Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1 | Descriptor: | Cellular tumor antigen p53, Lethal(3)malignant brain tumor-like protein | Authors: | Roy, S, West, L.E, Weiner, K.L, Hayashi, R, Shi, X, Appella, E, Gozani, O, Kutateladze, T. | Deposit date: | 2010-09-02 | Release date: | 2010-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5005 Å) | Cite: | The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression. J.Biol.Chem., 285, 2010
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5IOK
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6WXK
| PHF23 PHD Domain Apo | Descriptor: | PHD finger protein 23, ZINC ION | Authors: | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | Deposit date: | 2020-05-11 | Release date: | 2020-07-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nat Commun, 11, 2020
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5XNV
| Crystal structure of YEATS2 YEATS bound to H3K27ac peptide | Descriptor: | ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, AMMONIUM ION, CHLORIDE ION, ... | Authors: | Li, H.T, Guan, H.P, Zhao, D. | Deposit date: | 2017-05-24 | Release date: | 2017-11-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.696 Å) | Cite: | YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nat Commun, 8, 2017
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