5U28
BRD4 first bromodomain (BD1) in complex with dual PI3 kinase inhibitor SF2523
Summary for 5U28
Entry DOI | 10.2210/pdb5u28/pdb |
Related | 5U2C 5U2E 5U2F |
Descriptor | Bromodomain-containing protein 4, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | bromodomain, transcription, inhibitor, epigenetics, transcription regulator-inhibitor complex, transcription regulator/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 16774.34 |
Authors | Andrews, F.H.,Kutateladze, T.G. (deposition date: 2016-11-30, release date: 2017-02-08, Last modification date: 2023-10-04) |
Primary citation | Andrews, F.H.,Singh, A.R.,Joshi, S.,Smith, C.A.,Morales, G.A.,Garlich, J.R.,Durden, D.L.,Kutateladze, T.G. Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis. Proc. Natl. Acad. Sci. U.S.A., 114:E1072-E1080, 2017 Cited by PubMed: 28137841DOI: 10.1073/pnas.1613091114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.798 Å) |
Structure validation
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