5U28
BRD4 first bromodomain (BD1) in complex with dual PI3 kinase inhibitor SF2523
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 4 | polymer | 138 | 16238.7 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | A | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one | non-polymer | 371.4 | 1 | Chemie (82V) | |||
| 3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | A | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 5 | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A: 44 - 180 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ala 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16238.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 535.6 | |
| All* | Total formula weight | 16774.3 |
