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4GZP
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BU of 4gzp by Molmil
N2 Neuraminidase of A/Tanzania/205/2010 H3N2 in complex with oseltamivir carboxylate
Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
J.Virol., 86, 2012
4GZW
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BU of 4gzw by Molmil
N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with avian sialic acid receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
J.Virol., 86, 2012
4HF5
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BU of 4hf5 by Molmil
Crystal structure of Fab 8F8 in complex a H2N2 influenza virus hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 8F8 heavy chain, Fab 8F8 light chain, ...
Authors:Xu, R, Wilson, I.A.
Deposit date:2012-10-04
Release date:2013-02-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Nat.Struct.Mol.Biol., 20, 2013
1NJ9
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BU of 1nj9 by Molmil
Cocaine hydrolytic antibody 15A10
Descriptor: SODIUM ION, immunoglobulin heavy chain, immunoglobulin variable chain
Authors:Larsen, N.A, de Prada, P, Deng, S.X, Zhu, X, Landry, D.W, Wilson, I.A.
Deposit date:2002-12-30
Release date:2004-02-17
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10.
Biochemistry, 43, 2004
4GXV
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BU of 4gxv by Molmil
Crystal structure of anti-influenza virus antibody 1F1
Descriptor: Antibody 1F1, heavy chain, light chain
Authors:Ekiert, D.C, Wilson, I.A.
Deposit date:2012-09-04
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.449 Å)
Cite:Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses.
Plos Pathog., 8, 2012
4HG4
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BU of 4hg4 by Molmil
Crystal structure of Fab 2G1 in complex with a H2N2 influenza virus hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2G1 heavy chain, ...
Authors:Xu, R, Wilson, I.A.
Deposit date:2012-10-06
Release date:2013-02-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Nat.Struct.Mol.Biol., 20, 2013
4HJS
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BU of 4hjs by Molmil
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide
Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide, Transthyretin
Authors:Connelly, S, Wilson, I.A.
Deposit date:2012-10-14
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
4HJU
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BU of 4hju by Molmil
Transthyretin in complex with (E)-N-(3-(4-hydroxy-3,5-dimethylstyryl)phenyl)acrylamide
Descriptor: N-{3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}prop-2-enamide, Transthyretin
Authors:Connelly, S, Wilson, I.A.
Deposit date:2012-10-14
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
4HJT
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BU of 4hjt by Molmil
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide
Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide, Transthyretin
Authors:Connelly, S, Wilson, I.A.
Deposit date:2012-10-14
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
4HLZ
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BU of 4hlz by Molmil
Crystal Structure of Fab C179 in Complex with a H2N2 influenza virus hemagglutinin
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Dreyfus, C, Wilson, I.A.
Deposit date:2012-10-17
Release date:2013-04-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a classical broadly neutralizing stem antibody in complex with a pandemic h2 influenza virus hemagglutinin.
J.Virol., 87, 2013
4I78
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BU of 4i78 by Molmil
Crystal structure of a subtype H17 hemagglutinin homologue from A/little yellow-shouldered bat/Guatemala/060/2010 (H17N10)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1, Hemagglutinin HA2, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2012-11-30
Release date:2013-01-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GZS
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BU of 4gzs by Molmil
N2 neuraminidase D151G mutant of a/Tanzania/205/2010 H3N2 in complex with hepes
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
J.Virol., 86, 2012
4GXX
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BU of 4gxx by Molmil
Crystal structure of the "avianized" 1918 influenza virus hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ...
Authors:Ekiert, D.C, Wilson, I.A.
Deposit date:2012-09-04
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses.
Plos Pathog., 8, 2012
4GZO
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BU of 4gzo by Molmil
N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with hepes
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
J.Virol., 86, 2012
4GZX
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BU of 4gzx by Molmil
N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with human sialic acid receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2012-09-06
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.
J.Virol., 86, 2012
4FI8
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BU of 4fi8 by Molmil
Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
Descriptor: 4-bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin
Authors:Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W.
Deposit date:2012-06-08
Release date:2013-02-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013
4FNK
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BU of 4fnk by Molmil
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Ekiert, D.C, Wilson, I.A.
Deposit date:2012-06-19
Release date:2012-09-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Cross-neutralization of influenza A viruses mediated by a single antibody loop.
Nature, 489, 2012
4FQK
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BU of 4fqk by Molmil
Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody CR8059 Heavy Chain, ...
Authors:Dreyfus, C, Laursen, N.S, Wilson, I.A.
Deposit date:2012-06-25
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (5.65 Å)
Cite:Highly conserved protective epitopes on influenza B viruses.
Science, 337, 2012
1RUA
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BU of 1rua by Molmil
Crystal structure (B) of u.v.-irradiated cationic cyclization antibody 4C6 fab at pH 4.6 with a data set collected at SSRL beamline 11-1.
Descriptor: ACETATE ION, BENZOIC ACID, GLYCEROL, ...
Authors:Zhu, X, Wentworth Jr, P, Wentworth, A.D, Eschenmoser, A, Lerner, R.A, Wilson, I.A.
Deposit date:2003-12-11
Release date:2004-03-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.
Proc.Natl.Acad.Sci.USA, 110, 2004
1RUM
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BU of 1rum by Molmil
Crystal structure (F) of H2O2-soaked cationic cyclization antibody 4C6 fab at pH 8.5 with a data set collected at SSRL beamline 9-1.
Descriptor: BENZOIC ACID, GLYCEROL, immunoglobulin igg2a, ...
Authors:Zhu, X, Wentworth Jr, P, Wentworth, A.D, Eschenmoser, A, Lerner, R.A, Wilson, I.A.
Deposit date:2003-12-11
Release date:2004-03-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.
Proc.Natl.Acad.Sci.USA, 110, 2004
4NZT
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BU of 4nzt by Molmil
Crystal structure of the antibody-binding region of Protein M (Protein M TD) in complex with anti-infleunza hemagglutinin antibody CR9114 Fab
Descriptor: CR9114 heavy chain, CR9114 light chain, Protein M TD
Authors:Zhu, X, Wilson, I.A.
Deposit date:2013-12-12
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.
Science, 343, 2014
4NUJ
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BU of 4nuj by Molmil
Crystal structure of HIV-1 broadly neutralizing antibody PGT152
Descriptor: PGT152 heavy chain, PGT152 light chain
Authors:Blattner, C, Wilson, I.A.
Deposit date:2013-12-03
Release date:2014-05-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.827 Å)
Cite:Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers.
Immunity, 40, 2014
4NZU
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BU of 4nzu by Molmil
Crystal structure of the primary monoclonal antibody 13PL Fab' from a multiple myeloma patient
Descriptor: 13PL heavy chain, 13PL light chain, ACETATE ION, ...
Authors:Zhu, X, Wilson, I.A.
Deposit date:2013-12-12
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.
Science, 343, 2014
4O58
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BU of 4o58 by Molmil
Crystal structure of broadly neutralizing antibody F045-092 in complex with A/Victoria/3/1975 (H3N2) influenza hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Lee, P.S, Wilson, I.A.
Deposit date:2013-12-19
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.7501 Å)
Cite:Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus.
Nat Commun, 5, 2014
4JM4
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BU of 4jm4 by Molmil
Crystal Structure of PGT 135 Fab
Descriptor: PGT 135 Heavy Chain, PGT 135 Light Chain
Authors:Kong, L, Wilson, I.A.
Deposit date:2013-03-13
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nat.Struct.Mol.Biol., 20, 2013

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