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3O6B
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BU of 3o6b by Molmil
A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB) low resolution
Descriptor: Cell division control protein 53, Defective in cullin neddylation protein 1
Authors:Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
Deposit date:2010-07-28
Release date:2010-09-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
4PXA
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BU of 4pxa by Molmil
DEAD-box RNA helicase DDX3X Cancer-associated mutant D354V
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X, PHOSPHATE ION
Authors:Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
Deposit date:2014-03-22
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
4PX9
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BU of 4px9 by Molmil
DEAD-box RNA helicase DDX3X Domain 1 with N-terminal ATP-binding Loop
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX3X
Authors:Epling, L.B, Grace, C.R, Lowe, B.R, Partridge, J.F, Enemark, E.J.
Deposit date:2014-03-22
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
J.Mol.Biol., 427, 2015
4R2Y
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BU of 4r2y by Molmil
Crystal structure of APC11 RING domain
Descriptor: Anaphase-promoting complex subunit 11, ZINC ION
Authors:Brown, N.G, Watson, E.R, Weissmann, F, Jarvis, M.A, Vanderlinden, R, Grace, C.R.R, Frye, J.J, Dube, P, Qiao, R, Petzold, G, Cho, S.E, Alsharif, O, Bao, J, Zheng, J, Nourse, A, Kurinov, I, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2014-08-13
Release date:2014-10-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.755 Å)
Cite:Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly.
Mol.Cell, 56, 2014
6OB1
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BU of 6ob1 by Molmil
Structure of WHB in complex with Ubiquitin Variant
Descriptor: Anaphase-promoting complex subunit 2, Ubiquitin
Authors:Edmond, R.W, Grace, C.R.
Deposit date:2019-03-19
Release date:2019-08-14
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
3O2U
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BU of 3o2u by Molmil
S. cerevisiae Ubc12
Descriptor: GLYCEROL, NEDD8-conjugating enzyme UBC12
Authors:Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
3O2P
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BU of 3o2p by Molmil
A Dual E3 Mechanism for Rub1 Ligation to Cdc53: Dcn1(P)-Cdc53(WHB)
Descriptor: Cell division control protein 53, Defective in cullin neddylation protein 1, GLYCEROL
Authors:Scott, D.C, Monda, J.K, Grace, C.R.R, Duda, D.M, Kriwacki, R.W, Kurz, T, Schulman, B.A.
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.233 Å)
Cite:A dual E3 mechanism for Rub1 ligation to Cdc53.
Mol.Cell, 39, 2010
2M5B
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BU of 2m5b by Molmil
The NMR structure of the BID-BAK complex
Descriptor: Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB
Authors:Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R.
Deposit date:2013-02-19
Release date:2013-04-17
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:BID-induced structural changes in BAK promote apoptosis.
Nat.Struct.Mol.Biol., 20, 2013
3RTR
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BU of 3rtr by Molmil
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
Descriptor: Cullin-1, E3 ubiquitin-protein ligase RBX1, ZINC ION
Authors:Calabrese, M.F, Scott, D.C, Duda, D.M, Grace, C.R, Kurinov, I, Kriwacki, R.W, Schulman, B.A.
Deposit date:2011-05-03
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Nat.Struct.Mol.Biol., 18, 2011
2RMI
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BU of 2rmi by Molmil
3D NMR structure of astressin
Descriptor: astressin
Authors:Royappa, G.C.R, Cervini, L, Gulyas, J, Rivier, J, Riek, R.
Deposit date:2007-10-17
Release date:2007-10-30
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide
Biopolymers, 87, 2007
6D74
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BU of 6d74 by Molmil
Direct Activation of the Executioner Domain of MLKL by a Select Repertoire of Inositol Phosphates
Descriptor: Mixed lineage kinase domain-like protein
Authors:Royappa, G.C, McNamara, D.E, Moldoveanu, T.
Deposit date:2018-04-24
Release date:2019-05-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
Cell Chem Biol, 26, 2019
6MH9
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BU of 6mh9 by Molmil
The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein A121I mutant to 2.02 Angstrom resolution
Descriptor: Fatty Acid Kinase (Fak) B1 protein, PALMITIC ACID
Authors:Cuypers, M.G, Ericson, M, Subramanian, C, White, S.W, Rock, C.O.
Deposit date:2018-09-17
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes.
J.Biol.Chem., 298, 2022
7M5B
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BU of 7m5b by Molmil
Crystal Structure of human BAK in complex with M3W5_BID
Descriptor: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer, COPPER (II) ION
Authors:Singh, G, Aggarwal, A, Moldoveanu, T.
Deposit date:2021-03-23
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
7M5C
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BU of 7m5c by Molmil
Crystal Structure of human BAK in complex with WT BAK BH3 peptide
Descriptor: Bcl-2 homologous antagonist/killer, COPPER (II) ION, SULFATE ION
Authors:Singh, G, Aggarwal, A, Moldoveanu, T.
Deposit date:2021-03-23
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
7M5A
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BU of 7m5a by Molmil
Crystal Structure of human BAK in complex with W3W5_BID
Descriptor: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer
Authors:Singh, G, Aggarwal, A, Moldoveanu, T.
Deposit date:2021-03-23
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
6ASR
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BU of 6asr by Molmil
REV1 UBM2 domain complex with ubiquitin
Descriptor: DNA repair protein REV1, NICKEL (II) ION, Ubiquitin
Authors:Miller, D.J.
Deposit date:2017-08-25
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.356 Å)
Cite:Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
J. Mol. Biol., 430, 2018
6AXD
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BU of 6axd by Molmil
Structures of REV1 UBM2 domain complex with ubiquitin and with the first small-molecule that inhibits the REV1 UBM2-ubiquitin interaction
Descriptor: DNA repair protein REV1
Authors:Fujii, N, Vanarotti, M.
Deposit date:2017-09-06
Release date:2018-06-27
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
J. Mol. Biol., 430, 2018
6NM1
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BU of 6nm1 by Molmil
The crystal structure of the Staphylococcus aureus Fatty acid Kinase (Fak) B1 protein A158L mutant to 2.33 Angstrom resolution exhibits a conformation change compared to the wild type form
Descriptor: Fatty acid Kinase (Fak) B1 protein, MYRISTIC ACID
Authors:Cuypers, M.G, Gullett, J.M, Subramanian, C, Ericson, M, White, S.W, Rock, C.O.
Deposit date:2019-01-10
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes.
J.Biol.Chem., 298, 2022
4HNJ
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BU of 4hnj by Molmil
Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution
Descriptor: Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:Fisher, J.C, Yun, M.K, White, S.W.
Deposit date:2012-10-19
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat.Chem.Biol., 9, 2013
4N8M
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BU of 4n8m by Molmil
Structural polymorphism in the N-terminal oligomerization domain of NPM1
Descriptor: COBALT (II) ION, Nucleophosmin
Authors:Mitrea, D, Royappa, G, Buljan, M, Yun, M, Pytel, N, Satumba, J, Nourse, A, Park, C, Babu, M.M, White, S.W, Kriwacki, R.W.
Deposit date:2013-10-17
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Proc.Natl.Acad.Sci.USA, 111, 2014
8UR6
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BU of 8ur6 by Molmil
Cryo-EM reconstruction of Staphylococcus aureus oleate hydratase (OhyA) dimer with a disordered C-terminal membrane-association domain
Descriptor: Oleate hydratase
Authors:Oldham, M.L, Qayyum, M.Z.
Deposit date:2023-10-25
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer.
J.Biol.Chem., 300, 2024
8UR3
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BU of 8ur3 by Molmil
Cryo-EM reconstruction of Staphylococcus aureus Oleate hydratase (OhyA) dimer with an ordered C-terminal membrane-association domain
Descriptor: Oleate hydratase
Authors:Oldham, M.L, Qayyum, M.Z.
Deposit date:2023-10-25
Release date:2024-01-10
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:The carboxy terminus causes interfacial assembly of oleate hydratase on a membrane bilayer.
J.Biol.Chem., 300, 2024
5L9U
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BU of 5l9u by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-09-14
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9T
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BU of 5l9t by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-10-26
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5JG6
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BU of 5jg6 by Molmil
APC11-Ubv shows role of noncovalent RING-Ubiquitin interactions in processive multiubiquitination and Ubiquitin chain elongation by APC/C
Descriptor: Anaphase-promoting complex subunit 11, Polyubiquitin-B, ZINC ION
Authors:Brown, N.G, Zhang, W, Yu, S, Miller, D.J, Sidhu, S.S, Schulman, B.A.
Deposit date:2016-04-19
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.0013 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016

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