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4IJM
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BU of 4ijm by Molmil
Crystal structure of circadian clock protein KaiC A422V mutant
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION, ...
Authors:Egli, M, Pattanayek, R.
Deposit date:2012-12-21
Release date:2013-02-13
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.352 Å)
Cite:Loop-Loop Interactions Regulate KaiA-Stimulated KaiC Phosphorylation in the Cyanobacterial KaiABC Circadian Clock.
Biochemistry, 52, 2013
1D48
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BU of 1d48 by Molmil
STRUCTURE OF THE PURE-SPERMINE FORM OF Z-DNA (MAGNESIUM FREE) AT 1 ANGSTROM RESOLUTION
Descriptor: DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), SPERMINE
Authors:Egli, M, Williams, L.D, Gao, Q, Rich, A.
Deposit date:1991-09-11
Release date:1992-04-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structure of the pure-spermine form of Z-DNA (magnesium free) at 1-A resolution.
Biochemistry, 30, 1991
3EY2
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BU of 3ey2 by Molmil
A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution
Descriptor: 5'-D(*GP*CP*GP*TP*AP*(USM)P*AP*CP*GP*C)-3', N-methylpropane-1,3-diamine
Authors:Egli, M, Pallan, P.S.
Deposit date:2008-10-17
Release date:2009-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3EY3
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BU of 3ey3 by Molmil
A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*(USM)P*CP*GP*CP*G)-3', STRONTIUM ION
Authors:Egli, M, Pallan, P.S.
Deposit date:2008-10-17
Release date:2009-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3EY1
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BU of 3ey1 by Molmil
A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution
Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*(USM)P*CP*GP*CP*G)-3', GLYCEROL, Ribonuclease H
Authors:Egli, M, Pallan, P.S.
Deposit date:2008-10-17
Release date:2009-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3HR3
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BU of 3hr3 by Molmil
Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Hydrophobic Modifications Better than DNA
Descriptor: 5'-D(*GP*CP*GP*(US4)P*(OMU))P*AP*CP*GP*C)-3'
Authors:Egli, M, Pallan, P.S.
Deposit date:2009-06-08
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.
J.Am.Chem.Soc., 131, 2009
2G92
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BU of 2g92 by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
Descriptor: 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3'
Authors:Egli, M, Li, F.
Deposit date:2006-03-04
Release date:2006-04-18
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
Acs Chem.Biol., 1, 2006
3I8D
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BU of 3i8d by Molmil
The Pairing Geometry of the Hydrophobic Thymine Analog 2,4-Difluorotoluene in Duplex DNA as Analyzed by X-ray Crystallography
Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*TP*(DFT)P*CP*GP*CP*G)-3', GLYCEROL, Ribonuclease H
Authors:Egli, M, Pallan, P.S.
Deposit date:2009-07-09
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Pairing geometry of the hydrophobic thymine analogue 2,4-difluorotoluene in duplex DNA as analyzed by X-ray crystallography.
J.Am.Chem.Soc., 131, 2009
2FIL
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BU of 2fil by Molmil
Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)
Descriptor: 5'-D(*GP*CP*GP*TP*(A2M)P*(TAF)P*AP*CP*GP*C)-3', COBALT HEXAMMINE(III)
Authors:Egli, M, Li, F.
Deposit date:2005-12-29
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, 2006
2FII
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BU of 2fii by Molmil
Crystal Structure Analysis of the B-DNA Dodecamer CGCGAAT-aU-CGCG, with Incorporated Arabino-Uridin (aU)
Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*TP*(UAR)P*CP*GP*CP*G)-3', MAGNESIUM ION
Authors:Egli, M, Li, F.
Deposit date:2005-12-29
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, 2006
2FIH
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BU of 2fih by Molmil
Crystal Structure Analysis of the B-DNA Dodecamer CGCGAA-aU-TCGCG, with Incorporated Arabino-Uridine (aU)
Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*(UAR)P*TP*CP*GP*CP*G)-3', MAGNESIUM ION
Authors:Egli, M, Li, F.
Deposit date:2005-12-29
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, 2006
2FIJ
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BU of 2fij by Molmil
Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-aU-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and Arabino-Uridine (aU)
Descriptor: 5'-D(*GP*CP*GP*TP*(A2M)P*(UAR)P*AP*CP*GP*C)-3', CHLORIDE ION, COBALT HEXAMMINE(III)
Authors:Egli, M, Li, F.
Deposit date:2005-12-29
Release date:2006-05-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, 2006
4OPK
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BU of 4opk by Molmil
Bh-RNaseH:2'-SMe-DNA complex
Descriptor: 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*TP*CP*GP*CP*G)-3', GLYCEROL, Ribonuclease H
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-02-05
Release date:2015-02-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.539 Å)
Cite:Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Methods Mol.Biol., 1320
4OPJ
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BU of 4opj by Molmil
Bh-RNaseH:tcdA-DNA complex
Descriptor: 5'-D(*CP*GP*CP*GP*AP*(TCY)P*TP*TP*CP*GP*CP*G)-3', GLYCEROL, Ribonuclease H
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-02-05
Release date:2015-02-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Methods Mol.Biol., 1320
4DKZ
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BU of 4dkz by Molmil
Hairpin structure of a DNA dodecamer containing North-methanocarba-2'-deoxythymidine
Descriptor: Synthetic DNA dodecamer containg North-methanocarba-2'-deoxythymidine (N-MCdT)
Authors:Egli, M, Pallan, P.S.
Deposit date:2012-02-05
Release date:2012-03-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin.
Biochemistry, 51, 2012
3Q61
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BU of 3q61 by Molmil
3'-Fluoro Hexitol Nucleic Acid DNA Structure
Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3')
Authors:Seth, P.R, Allerson, C.R, Prakash, T.P, Siwkowski, A, Berdeja, A, Yu, J, Pallan, P.S, Watt, A.T, Gaus, H, Bhat, B, Egli, M, Swayze, E.E.
Deposit date:2010-12-30
Release date:2012-01-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.
J.Am.Chem.Soc., 133, 2011
8VOU
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BU of 8vou by Molmil
Human glutathione transferase M1-1 in complex with the adduct between glutathione and nitrooleic acid
Descriptor: GLUTATHIONE, Glutathione S-transferase Mu 1, L-gamma-glutamyl-S-[(8R,9S)-1-carboxy-9-nitroheptadecan-8-yl]-L-cysteinylglycine
Authors:Larrieux, N, Steglich, M, Dalla Rizza, J, Buschiazzo, A, Turell, L.
Deposit date:2024-01-16
Release date:2025-03-12
Last modified:2025-04-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Human glutathione transferases catalyze the reaction between glutathione and nitrooleic acid.
J.Biol.Chem., 301, 2025
2IDK
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BU of 2idk by Molmil
Crystal Structure of Rat Glycine N-Methyltransferase Complexed With Folate
Descriptor: 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Glycine N-methyltransferase
Authors:Luka, Z, Pakhomova, S, Loukachevitch, L.V, Egli, M, Newcomer, M.E, Wagner, C.
Deposit date:2006-09-15
Release date:2006-12-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.
J.Biol.Chem., 282, 2007
3K0E
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BU of 3k0e by Molmil
Crystal structure of the phosphorylation-site mutant T426N of the KaiC circadian clock protein
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION
Authors:Pattanayek, R, Egli, M, Pattanayek, S.
Deposit date:2009-09-24
Release date:2010-03-31
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of KaiC Circadian Clock Mutant Proteins: A New Phosphorylation Site at T426 and Mechanisms of Kinase, ATPase and Phosphatase.
Plos One, 4, 2009
9BF0
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BU of 9bf0 by Molmil
MID domain of human Argo2 bound to UTP
Descriptor: Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
9BF2
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BU of 9bf2 by Molmil
MID domain of Ago2 bound to UMP
Descriptor: Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
9BEZ
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BU of 9bez by Molmil
MID domain of human Argo2 bound to RNA
Descriptor: Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
1U9I
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BU of 1u9i by Molmil
Crystal Structure of Circadian Clock Protein KaiC with Phosphorylation Sites
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, KaiC, MAGNESIUM ION
Authors:Xu, Y, Mori, T, Pattanayek, R, Pattanayek, S, Egli, M, Johnson, C.H.
Deposit date:2004-08-09
Release date:2005-04-19
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses
PROC.NATL.ACAD.SCI.USA, 101, 2004
3CJZ
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BU of 3cjz by Molmil
Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G:A pairs
Descriptor: RNA (5'-R(*GP*GP*AP*CP*GP*(M2G)P*AP*CP*GP*UP*CP*CP*U)-3')
Authors:Pallan, P.S, Kreutz, C, Bosio, S, Micura, R, Egli, M.
Deposit date:2008-03-14
Release date:2008-10-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs.
Rna, 14, 2008
5JUM
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BU of 5jum by Molmil
Crystal Structure of Human DNA Polymerase Eta Inserting dCTP Opposite N-(2'-deoxyguanosin-8- yl)-3-aminobenzanthrone (C8-dG-ABA)
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Patra, A, Politica, D.A, Stone, M.P, Egli, M.
Deposit date:2016-05-10
Release date:2016-09-07
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Mechanism of Error-Free Bypass of the Environmental Carcinogen N-(2'-Deoxyguanosin-8-yl)-3-aminobenzanthrone Adduct by Human DNA Polymerase eta.
Chembiochem, 17, 2016

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