3Q61

3'-Fluoro Hexitol Nucleic Acid DNA Structure

Summary for 3Q61

• Entry DOI: 10.2210/pdb3q61/pdb
• Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3') (2 entities in total)
• Functional Keywords: a-form dna, 3'-fluoro hexitol nucleic acid, fhna, antisense oligonucleotides, dna
• Total number of polymer chains: 2
• Total formula weight: 6154.05

Authors

Seth, P.R.,Allerson, C.R.,Prakash, T.P.,Siwkowski, A.,Berdeja, A.,Yu, J.,Pallan, P.S.,Watt, A.T.,Gaus, H.,Bhat, B.,Egli, M.,Swayze, E.E. (deposition date: 2010-12-30, release date: 2012-01-18, Last modification date: 2023-09-13)

• Primary citation: Egli, M.,Pallan, P.S.,Allerson, C.R.,Prakash, T.P.,Berdeja, A.,Yu, J.,Lee, S.,Watt, A.,Gaus, H.,Bhat, B.,Swayze, E.E.,Seth, P.P.; Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.; J.Am.Chem.Soc., 133:16642-16649, 2011; PubMed: 21919455; DOI: 10.1021/ja207086x

Experimental method

X-RAY DIFFRACTION (1.56 Å)