4GHQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ghq by Molmil](/molmil-images/mine/4ghq) | Crystal structure of EV71 3C proteinase | Descriptor: | 3C proteinase | Authors: | Chen, C, Wu, C, Cai, Q, Li, N, Peng, X, Cai, Y, Yin, K, Chen, X, Wang, X, Zhang, R, Liu, L, Chen, S, Li, J, Lin, T. | Deposit date: | 2012-08-08 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir Acta Crystallogr.,Sect.D, 69, 2013
|
|
8F8Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f8y by Molmil](/molmil-images/mine/8f8y) | PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide | Descriptor: | 1,2-ETHANEDIOL, Lysine-specific demethylase PHF2, SULFATE ION, ... | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2022-11-22 | Release date: | 2023-01-18 | Last modified: | 2023-02-08 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299, 2022
|
|
8F8Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8f8z by Molmil](/molmil-images/mine/8f8z) | |
2E0H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2e0h by Molmil](/molmil-images/mine/2e0h) | |
1C8J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1c8j by Molmil](/molmil-images/mine/1c8j) | CRYSTAL STRUCTURE OF CYTOCHROME P450CAM MUTANT (F87W/Y96F) | Descriptor: | CYTOCHROME P450-CAM, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Liu, Y, Jiang, F, Guo, Q, Chen, X, Jin, J, Sun, Y, Rao, Z. | Deposit date: | 2000-05-31 | Release date: | 2001-05-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Cytochrome P450cam mutant (F87W/Y96F) To be Published
|
|
1YVL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yvl by Molmil](/molmil-images/mine/1yvl) | Structure of Unphosphorylated STAT1 | Descriptor: | 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta | Authors: | Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X. | Deposit date: | 2005-02-16 | Release date: | 2005-03-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural bases of unphosphorylated STAT1 association and receptor binding. Mol.Cell, 17, 2005
|
|
3VCB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vcb by Molmil](/molmil-images/mine/3vcb) | C425S mutant of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59 | Descriptor: | RNA-directed RNA polymerase | Authors: | Xu, X, Lou, Z, Ma, Y, Chen, X, Yang, Z, Tong, X, Zhao, Q, Xu, Y, Deng, H, Bartlam, M, Rao, Z. | Deposit date: | 2012-01-03 | Release date: | 2012-01-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. Plos One, 4, 2009
|
|
8KG5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8kg5 by Molmil](/molmil-images/mine/8kg5) | Prefusion RSV F Bound to Lonafarnib and D25 Fab | Descriptor: | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ... | Authors: | Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X. | Deposit date: | 2023-08-17 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein. Signal Transduct Target Ther, 9, 2024
|
|
3VC8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vc8 by Molmil](/molmil-images/mine/3vc8) | Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59 | Descriptor: | RNA-directed RNA polymerase | Authors: | Xu, X, Lou, Z, Ma, Y, Chen, X, Yang, Z, Tong, X, Zhao, Q, Xu, Y, Deng, H, Bartlam, M, Rao, Z. | Deposit date: | 2012-01-03 | Release date: | 2012-01-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the C-terminal cytoplasmic domain of non-structural protein 4 from mouse hepatitis virus A59. Plos One, 4, 2009
|
|
1QES
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qes by Molmil](/molmil-images/mine/1qes) | TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES | Descriptor: | RNA (5'-R(*GP*GP*AP*GP*UP*UP*CP*C)-3') | Authors: | Mcdowell, J.A, He, L, Chen, X, Turner, D.H. | Deposit date: | 1997-03-04 | Release date: | 1997-06-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2. Biochemistry, 36, 1997
|
|
7YJI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7yji by Molmil](/molmil-images/mine/7yji) | |
1IK1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ik1 by Molmil](/molmil-images/mine/1ik1) | Solution Structure of an RNA Hairpin from HRV-14 | Descriptor: | 5'-R(*GP*GP*UP*AP*CP*UP*AP*UP*GP*UP*AP*CP*CP*A)-3' | Authors: | Huang, H, Alexandrov, A, Chen, X, Barnes III, T.W, Zhang, H, Dutta, K, Pascal, S.M. | Deposit date: | 2001-05-01 | Release date: | 2001-07-18 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of an RNA hairpin from HRV-14. Biochemistry, 40, 2001
|
|
4IAN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ian by Molmil](/molmil-images/mine/4ian) | Crystal Structure of apo Human PRPF4B kinase domain | Descriptor: | SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | Authors: | Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. | Deposit date: | 2012-12-06 | Release date: | 2013-08-28 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
|
|
4IFC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ifc by Molmil](/molmil-images/mine/4ifc) | Crystal Structure of ADP-bound Human PRPF4B kinase domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | Authors: | Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. | Deposit date: | 2012-12-14 | Release date: | 2013-08-28 | Last modified: | 2013-11-06 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
|
|
4IJP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ijp by Molmil](/molmil-images/mine/4ijp) | Crystal Structure of Human PRPF4B kinase domain in complex with 4-{5-[(2-Chloro-pyridin-4-ylmethyl)-carbamoyl]-thiophen-2-yl}-benzo[b]thiophene-2-carboxylic acid amine | Descriptor: | 4-(5-{[(2-chloropyridin-4-yl)methyl]carbamoyl}thiophen-2-yl)-1-benzothiophene-2-carboxamide, SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | Authors: | Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. | Deposit date: | 2012-12-22 | Release date: | 2013-08-28 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
|
|
4IIR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iir by Molmil](/molmil-images/mine/4iir) | Crystal Structure of AMPPNP-bound Human PRPF4B kinase domain | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... | Authors: | Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. | Deposit date: | 2012-12-20 | Release date: | 2013-08-28 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
|
|
1MI8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1mi8 by Molmil](/molmil-images/mine/1mi8) | 2.0 Angstrom crystal structure of a DnaB intein from Synechocystis sp. PCC 6803 | Descriptor: | DnaB intein | Authors: | Ding, Y, Chen, X, Ferrandon, S, Xu, M, Rao, Z. | Deposit date: | 2002-08-22 | Release date: | 2003-08-19 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing J.Biol.Chem., 278, 2003
|
|
1FIO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fio by Molmil](/molmil-images/mine/1fio) | CRYSTAL STRUCTURE OF YEAST T-SNARE PROTEIN SSO1 | Descriptor: | SSO1 PROTEIN, ZINC ION | Authors: | Munson, M, Chen, X, Cocina, A.E, Schultz, S.M, Hughson, F.M. | Deposit date: | 2000-08-04 | Release date: | 2000-10-11 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly. Nat.Struct.Biol., 7, 2000
|
|
7RSL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rsl by Molmil](/molmil-images/mine/7rsl) | Seipin forms a flexible cage at lipid droplet formation sites | Descriptor: | Seipin | Authors: | Arlt, H, Sui, X, Folger, B, Adams, C, Chen, X, Remme, R, Hamprecht, F.A, DiMaio, F, Liao, M, Goodman, J.M, Farese Jr, R.V, Walther, T.C. | Deposit date: | 2021-08-11 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Seipin forms a flexible cage at lipid droplet formation sites. Nat.Struct.Mol.Biol., 29, 2022
|
|
4EXP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4exp by Molmil](/molmil-images/mine/4exp) | Structure of mouse Interleukin-34 in complex with mouse FMS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-34, Macrophage colony-stimulating factor 1 receptor | Authors: | Liu, H, Leo, C, Chen, X, Wong, B.R, Williams, L.T, Lin, H, He, X. | Deposit date: | 2012-04-30 | Release date: | 2012-05-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim.Biophys.Acta, 1824, 2012
|
|
4EXN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4exn by Molmil](/molmil-images/mine/4exn) | Crystal structure of mouse Interleukin-34 | Descriptor: | Interleukin-34, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Liu, H, Leo, C, Chen, X, Wong, B.R, Williams, L.T, Lin, H, He, X. | Deposit date: | 2012-04-30 | Release date: | 2012-05-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1. Biochim.Biophys.Acta, 1824, 2012
|
|
1GH2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gh2 by Molmil](/molmil-images/mine/1gh2) | Crystal structure of the catalytic domain of a new human thioredoxin-like protein | Descriptor: | THIOREDOXIN-LIKE PROTEIN | Authors: | Jin, J, Chen, X, Guo, Q, Yuan, J, Qiang, B, Rao, Z. | Deposit date: | 2000-11-01 | Release date: | 2001-05-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Crystal structure of the catalytic domain of a human thioredoxin-like protein. Eur.J.Biochem., 269, 2002
|
|
4P3O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p3o by Molmil](/molmil-images/mine/4p3o) | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2 | Descriptor: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | Authors: | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | Deposit date: | 2014-03-09 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.505 Å) | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun, 6, 2015
|
|
4P3P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p3p by Molmil](/molmil-images/mine/4p3p) | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 3 | Descriptor: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | Authors: | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | Deposit date: | 2014-03-09 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun, 6, 2015
|
|
4P3N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4p3n by Molmil](/molmil-images/mine/4p3n) | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1 | Descriptor: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ... | Authors: | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | Deposit date: | 2014-03-09 | Release date: | 2015-03-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun, 6, 2015
|
|