8IZB
 
 | | Lysophosphatidylserine receptor GPR174-Gs complex | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Gong, W, Liu, G, Li, X, Zhang, X. | | Deposit date: | 2023-04-06 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174.
Plos Biol., 21, 2023
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8JKZ
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8JL0
 | | Cryo-EM structure of the prokaryotic SPARSA system complex | | Descriptor: | DNA (5'-D(P*AP*CP*GP*AP*CP*GP*TP*CP*TP*AP*AP*GP*AP*AP*AP*CP*CP*AP*TP*TP*AP*T)-3'), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Piwi domain protein, ... | | Authors: | Xu, X, Zhen, X, Long, F. | | Deposit date: | 2023-06-02 | | Release date: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system.
Nat Commun, 15, 2024
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8J72
 | | Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1 | | Descriptor: | E3 ubiquitin-protein ligase TRIM71, lncRNA Trincr1 | | Authors: | Shi, F.D, Zhang, K, Che, S.Y, Zhi, S.X, Yang, N. | | Deposit date: | 2023-04-27 | | Release date: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.16 Å) | | Cite: | Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein.
Sci Bull (Beijing), 69, 2024
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8JFK
 | | PhK holoenzyme in inactive state, muscle isoform | | Descriptor: | Calmodulin-1, FARNESYL, Phosphorylase b kinase gamma catalytic chain, ... | | Authors: | Yang, X.K, Xiao, J.Y. | | Deposit date: | 2023-05-18 | | Release date: | 2024-04-03 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Architecture and activation of human muscle phosphorylase kinase.
Nat Commun, 15, 2024
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8JFL
 | | PhK holoenzyme in active state, muscle isoform | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FARNESYL, Phosphorylase b kinase gamma catalytic chain, ... | | Authors: | Yang, X.K, Xiao, J.Y. | | Deposit date: | 2023-05-18 | | Release date: | 2024-04-03 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Architecture and activation of human muscle phosphorylase kinase.
Nat Commun, 15, 2024
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8IZ4
 | | Lysophosphatidylserine receptor GPR34-Gi complex | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Gong, W, Liu, G, Li, X, Zhang, X. | | Deposit date: | 2023-04-06 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors
To Be Published
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7VZT
 | | A human neutralizing antibody targeting SARS-CoV-2 RBD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GH12-Heavy, GH12-LIGHT, ... | | Authors: | Wang, F.Z, Wang, Y, Tan, X.W, Shi, R, Yan, J.H. | | Deposit date: | 2021-11-16 | | Release date: | 2023-05-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | GH12, glycosylation function
To Be Published
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8IZF
 | | Cryo-EM structure of the Lac1-Lip1 (Lip1-S74F) complex | | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1 | | Authors: | Xie, T, Fang, Q, Gong, X. | | Deposit date: | 2023-04-07 | | Release date: | 2023-12-13 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.85 Å) | | Cite: | Structure and mechanism of a eukaryotic ceramide synthase complex.
Embo J., 42, 2023
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8IZD
 | | Cryo-EM structure of the C26-CoA-bound Lac1-Lip1 complex | | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Ceramide synthase LAC1, Ceramide synthase subunit LIP1, ... | | Authors: | Xie, T, Fang, Q, Gong, X. | | Deposit date: | 2023-04-07 | | Release date: | 2023-12-13 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Structure and mechanism of a eukaryotic ceramide synthase complex.
Embo J., 42, 2023
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8IWT
 | | hSPCA1 in the early E2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWW
 | | hSPCA1 in the CaE1P-ADP state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWU
 | | hSPCA1 in the E2~P state | | Descriptor: | Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWS
 | | hSPCA1 in the CaE2P state | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWR
 | | hSPCA1 in the CaE1-ATP state | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-31 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8IWP
 | | hSPCA1 in the CaE1 state | | Descriptor: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1 | | Authors: | Liu, Z.M, Wu, M.Q, Wu, C. | | Deposit date: | 2023-03-30 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Structure and transport mechanism of the human calcium pump SPCA1.
Cell Res., 33, 2023
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8K7A
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8K4B
 | | Cryo-EM structure of nucleotide-bound ComA with ZinC ion | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Competence factor transporting ATP-binding protein/permease ComA, ZINC ION | | Authors: | Yu, L, Xin, X, Min, L, Feng, H. | | Deposit date: | 2023-07-17 | | Release date: | 2023-10-11 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of peptide secretion for Quorum sensing by ComA.
Nat Commun, 14, 2023
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8KGY
 | | Human glutamate dehydrogenase I | | Descriptor: | Glutamate dehydrogenase 1, mitochondrial | | Authors: | Su, M.-Y. | | Deposit date: | 2023-08-20 | | Release date: | 2023-10-25 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (2.59 Å) | | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Structure, 31, 2023
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8K8K
 | | Structure of Klebsiella pneumonia ModA | | Descriptor: | Molybdate transporter periplasmic protein | | Authors: | Zhao, Q, Bartlam, M. | | Deposit date: | 2023-07-31 | | Release date: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural analysis of molybdate binding protein ModA from Klebsiella pneumoniae.
Biochem.Biophys.Res.Commun., 681, 2023
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8K8L
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8KHP
 | | CULLIN3-KLHL22-RBX1 E3 ligase | | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22 | | Authors: | Su, M.-Y, Su, M.-Y. | | Deposit date: | 2023-08-22 | | Release date: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Structure, 31, 2023
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8KHR
 | | Cryo-EM structure of EBV gH/gL-gp42 in complex with fab 2C1 | | Descriptor: | 2C1 heavy chain, 2C1 light chain, Envelope glycoprotein H, ... | | Authors: | Fang, X.Y, Zhao, G.X, Zeng, M.S, Liu, Z. | | Deposit date: | 2023-08-22 | | Release date: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection.
Cell Rep Med, 5, 2024
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3QLH
 | | HIV-1 Reverse Transcriptase in Complex with Manicol at the RNase H Active Site and TMC278 (Rilpivirine) at the NNRTI Binding Pocket | | Descriptor: | (2S)-5,7-dihydroxy-9-methyl-2-(prop-1-en-2-yl)-1,2,3,4-tetrahydro-6H-benzo[7]annulen-6-one, 1,2-ETHANEDIOL, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... | | Authors: | Himmel, D.M, Wojtak, K, Bauman, J.D, Arnold, E. | | Deposit date: | 2011-02-02 | | Release date: | 2011-12-21 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J.Med.Chem., 54, 2011
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7F5W
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