3EOB
 
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3EOA
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3EO9
 | | Crystal structure the Fab fragment of Efalizumab | | Descriptor: | Efalizumab Fab fragment, heavy chain, light chain | | Authors: | Li, S, Ding, J. | | Deposit date: | 2008-09-26 | | Release date: | 2009-04-14 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3DOF
 | | Complex of ARL2 and BART, Crystal Form 2 | | Descriptor: | ADP-ribosylation factor-like protein 2, ADP-ribosylation factor-like protein 2-binding protein, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhang, T, Li, S, Ding, J. | | Deposit date: | 2008-07-04 | | Release date: | 2009-03-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector
Structure, 17, 2009
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7DF1
 | | Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv | | Descriptor: | 4F2 cell-surface antigen heavy chain, IGL c2062_light_IGKV4-1_IGKJ5, S1-F4 VH | | Authors: | Liu, X, Ding, J, Sui, J, Tian, X. | | Deposit date: | 2020-11-06 | | Release date: | 2022-12-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.806 Å) | | Cite: | An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.
Nat Biomed Eng, 2022
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6JWP
 | | crystal structure of EGOC | | Descriptor: | Ego2, GTP-binding protein GTR1, GTP-binding protein GTR2, ... | | Authors: | Zhang, T, Ding, J. | | Deposit date: | 2019-04-21 | | Release date: | 2019-12-11 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural insights into the EGO-TC-mediated membrane tethering of the TORC1-regulatory Rag GTPases.
Sci Adv, 5, 2019
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1T03
 | | HIV-1 reverse transcriptase crosslinked to tenofovir terminated template-primer (complex P) | | Descriptor: | MAGNESIUM ION, POL polyprotein, Synthetic oligonucleotide primer, ... | | Authors: | Tuske, S, Sarafianos, S.G, Ding, J, Arnold, E. | | Deposit date: | 2004-04-07 | | Release date: | 2004-05-11 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol., 11, 2004
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3DOE
 | | Complex of ARL2 and BART, Crystal Form 1 | | Descriptor: | ADP-ribosylation factor-like protein 2, ADP-ribosylation factor-like protein 2-binding protein, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Zhang, T, Li, S, Ding, J. | | Deposit date: | 2008-07-04 | | Release date: | 2009-03-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector
Structure, 17, 2009
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1T05
 | | HIV-1 reverse transcriptase crosslinked to template-primer with tenofovir-diphosphate bound as the incoming nucleotide substrate | | Descriptor: | GLYCEROL, MAGNESIUM ION, POL polyprotein, ... | | Authors: | Tuske, S, Sarafianos, S.G, Ding, J, Arnold, E. | | Deposit date: | 2004-04-07 | | Release date: | 2004-05-11 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol., 11, 2004
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3PPX
 | | Crystal structure of the N1602A mutant of an engineered VWF A2 domain (N1493C and C1670S) | | Descriptor: | SODIUM ION, von Willebrand factor | | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | | Deposit date: | 2010-11-25 | | Release date: | 2011-05-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13
Blood, 117, 2011
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3PPW
 | | Crystal structure of the D1596A mutant of an engineered VWF A2 domain (N1493C and C1670S) | | Descriptor: | SODIUM ION, von Willebrand factor | | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | | Deposit date: | 2010-11-25 | | Release date: | 2011-05-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13
Blood, 117, 2011
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3QAH
 | | Crystal structure of apo-form human MOF catalytic domain | | Descriptor: | Probable histone acetyltransferase MYST1, ZINC ION | | Authors: | Sun, B, Tang, Q, Zhong, C, Ding, J. | | Deposit date: | 2011-01-11 | | Release date: | 2011-07-06 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274
Cell Res., 21, 2011
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3RPN
 | | Crystal structure of human kappa class glutathione transferase in complex with S-hexylglutathione | | Descriptor: | Glutathione S-transferase kappa 1, S-HEXYLGLUTATHIONE | | Authors: | Wang, B, Peng, Y, Zhang, T, Ding, J. | | Deposit date: | 2011-04-27 | | Release date: | 2011-07-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism.
Biochem.J., 439, 2011
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3PPY
 | | Crystal structure of the D1596A/N1602A double mutant of an engineered VWF A2 domain (N1493C and C1670S) | | Descriptor: | SODIUM ION, von Willebrand factor | | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | | Deposit date: | 2010-11-25 | | Release date: | 2011-05-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13
Blood, 117, 2011
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3RIB
 | | Human lysine methyltransferase Smyd2 in complex with AdoHcy | | Descriptor: | N-lysine methyltransferase SMYD2, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | | Authors: | Xu, S, Zhang, T, Zhong, C, Ding, J. | | Deposit date: | 2011-04-13 | | Release date: | 2011-07-20 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins
J Mol Cell Biol, 3, 2011
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6JLQ
 | | Crystal structure of human USP46-WDR48-WDR20 complex | | Descriptor: | GLYCEROL, PHOSPHATE ION, Ubiquitin carboxyl-terminal hydrolase 46, ... | | Authors: | Zhu, H, Zhang, T, Ding, J. | | Deposit date: | 2019-03-06 | | Release date: | 2019-07-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.101 Å) | | Cite: | Structural insights into the activation of USP46 by WDR48 and WDR20.
Cell Discov, 5, 2019
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3PPV
 | | Crystal structure of an engineered VWF A2 domain (N1493C and C1670S) | | Descriptor: | CALCIUM ION, SULFATE ION, von Willebrand factor | | Authors: | Zhou, M, Dong, X, Zhong, C, Ding, J. | | Deposit date: | 2010-11-25 | | Release date: | 2011-05-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13
Blood, 117, 2011
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3SP4
 | | Crystal structure of aprataxin ortholog Hnt3 from Schizosaccharomyces pombe | | Descriptor: | Aprataxin-like protein, SULFATE ION, ZINC ION | | Authors: | Gong, Y, Zhu, D, Ding, J, Dou, C, Ren, X, Jiang, T, Wang, D. | | Deposit date: | 2011-07-01 | | Release date: | 2011-10-12 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA
Nat.Struct.Mol.Biol., 18, 2011
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6KDY
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3SPL
 | | Crystal structure of aprataxin ortholog Hnt3 in complex with DNA and AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin-like protein, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*GP*AP*G)-3'), ... | | Authors: | Gong, Y, Zhu, D, Ding, J, Dou, C, Ren, X, Jiang, T, Wang, D. | | Deposit date: | 2011-07-02 | | Release date: | 2011-10-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA
Nat.Struct.Mol.Biol., 18, 2011
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3RPP
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6KE3
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6KDF
 | | Crystal structure of the alpha beta heterodimer of human IDH3 in APO form. | | Descriptor: | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, Isocitrate dehydrogenase [NAD] subunit beta | | Authors: | Sun, P, Ding, J. | | Deposit date: | 2019-07-02 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Molecular basis for the function of the alpha beta heterodimer of human NAD-dependent isocitrate dehydrogenase.
J.Biol.Chem., 294, 2019
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6KDE
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3SPD
 | | Crystal structure of aprataxin ortholog Hnt3 in complex with DNA | | Descriptor: | Aprataxin-like protein, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*GP*AP*G)-3'), DNA (5'-D(*TP*AP*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*AP*C)-3'), ... | | Authors: | Gong, Y, Zhu, D, Ding, J, Dou, C, Ren, X, Jiang, T, Wang, D. | | Deposit date: | 2011-07-01 | | Release date: | 2011-10-12 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.912 Å) | | Cite: | Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA
Nat.Struct.Mol.Biol., 18, 2011
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