3GNI
 
 | | Structure of STRAD and MO25 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Protein Mo25, ... | | 著者 | Zeqiraj, E, Goldie, S, Alessi, D.R, van Aalten, D.M.F. | | 登録日 | 2009-03-17 | | 公開日 | 2009-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor
Plos Biol., 7, 2009
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5CW5
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5CW3
 | | Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge) | | 分子名称: | BRCA1/BRCA2-containing complex subunit 3, Protein FAM175B, ZINC ION | | 著者 | Zeqiraj, E. | | 登録日 | 2015-07-27 | | 公開日 | 2015-09-16 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.
Mol.Cell, 59, 2015
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4QLB
 | | Structural Basis for the Recruitment of Glycogen Synthase by Glycogenin | | 分子名称: | GLYCEROL, Probable glycogen [starch] synthase, Protein GYG-1, ... | | 著者 | Zeqiraj, E, Judd, A, Sicheri, F. | | 登録日 | 2014-06-11 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc.Natl.Acad.Sci.USA, 111, 2014
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2WTK
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5CW6
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5CW4
 | | Structure of CfBRCC36-CfKIAA0157 complex (Selenium Edge) | | 分子名称: | BRCA1/BRCA2-containing complex subunit 3, GLYCEROL, Protein FAM175B, ... | | 著者 | Zeqiraj, E. | | 登録日 | 2015-07-27 | | 公開日 | 2015-09-16 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.543 Å) | | 主引用文献 | Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.
Mol.Cell, 59, 2015
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8RHN
 | | Structure of the 55LCC ATPase complex | | 分子名称: | ATPase family gene 2 protein homolog A, ATPase family gene 2 protein homolog B, Cyclin-dependent kinase 2-interacting protein, ... | | 著者 | Foglizzo, M, Degtjarik, O, Zeqiraj, E. | | 登録日 | 2023-12-15 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.
Cell, 187, 2024
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7ZBN
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6R8F
 | | Cryo-EM structure of the Human BRISC-SHMT2 complex | | 分子名称: | BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2), BRISC complex subunit Abraxas 2, ... | | 著者 | Walden, M, Hesketh, E, Tian, L, Ranson, N.A, Greenberg, R.A, Zeqiraj, E. | | 登録日 | 2019-04-01 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.
Nature, 570, 2019
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3TZM
 | | TGF-beta Receptor type 1 in complex with SB431542 | | 分子名称: | 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide, TGF-beta receptor type-1 | | 著者 | Ogunjimi, A.A, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2011-09-27 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural Basis for Specificity of TGFbeta Family Receptor Small Molecule Inhibitors
Cell Signal, 24, 2012
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8CIH
 | | Structure of FL CINP | | 分子名称: | Cyclin-dependent kinase 2-interacting protein, SODIUM ION | | 著者 | Foglizzo, M, Zeqiraj, E. | | 登録日 | 2023-02-09 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.
Cell, 187, 2024
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8OFF
 | | Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1) | | 分子名称: | BRCA1 associated RING domain 1, DNA (142-MER), Histone H2A type 1, ... | | 著者 | Foglizzo, M, Burdett, H, Wilson, M.D, Zeqiraj, E. | | 登録日 | 2023-03-15 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes.
Nucleic Acids Res., 51, 2023
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8QFC
 | | UFL1 E3 ligase bound 60S ribosome | | 分子名称: | 60S ribosomal protein L10a, CDK5 regulatory subunit-associated protein 3, DDRGK domain-containing protein 1, ... | | 著者 | Makhlouf, L, Zeqiraj, E, Kulathu, Y. | | 登録日 | 2023-09-04 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
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8QFD
 | | UFL1 E3 ligase bound 60S ribosome | | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Makhlouf, L, Kulathu, Y, Zeqiraj, E. | | 登録日 | 2023-09-04 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
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4NKG
 | | Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain | | 分子名称: | E3 ubiquitin-protein ligase sspH1, HEXANE-1,6-DIOL, Serine/threonine-protein kinase N1 | | 著者 | Keszei, A.F.A, Xiaojing, T, Mccormick, C, Zeqiraj, E, Rohde, J.R, Tyers, M, Sicheri, F. | | 登録日 | 2013-11-12 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.
Mol.Cell.Biol., 34, 2014
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4NKH
 | | Crystal structure of SspH1 LRR domain | | 分子名称: | E3 ubiquitin-protein ligase sspH1 | | 著者 | Keszei, A.F.A, Xiaojing, T, Mccormick, C, Zeqiraj, E, Rohde, J.R, Tyers, M, Sicheri, F. | | 登録日 | 2013-11-12 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.
Mol.Cell.Biol., 34, 2014
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4O1O
 | | Crystal Structure of RNase L in complex with 2-5A | | 分子名称: | Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate | | 著者 | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2013-12-16 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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4O1P
 | | Crystal Structure of RNase L in complex with 2-5A and AMP-PNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonuclease L, ... | | 著者 | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2013-12-16 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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3I3T
 | | Crystal structure of covalent ubiquitin-USP21 complex | | 分子名称: | ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ... | | 著者 | Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2009-06-30 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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4I6L
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3V6E
 | | Crystal Structure of USP2 and a mutant form of Ubiquitin | | 分子名称: | CHLORIDE ION, GLYCEROL, Ubiquitin, ... | | 著者 | Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2011-12-19 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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3MTN
 | | Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor | | 分子名称: | CHLORIDE ION, GLYCEROL, UBIQUITIN VARIANT UBV.21.4, ... | | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2010-04-30 | | 公開日 | 2010-06-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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3N3K
 | | The catalytic domain of USP8 in complex with a USP8 specific inhibitor | | 分子名称: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION | | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | 登録日 | 2010-05-20 | | 公開日 | 2010-06-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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8C0D
 | | UFL1/DDRGK1 bound to UFC1 | | 分子名称: | DDRGK domain-containing protein 1, E3 UFM1-protein ligase 1, Ubiquitin-fold modifier-conjugating enzyme 1 | | 著者 | Magnussen, H.M, Kulathu, Y. | | 登録日 | 2022-12-16 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.564 Å) | | 主引用文献 | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
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