6R8F

Cryo-EM structure of the Human BRISC-SHMT2 complex

Summary for 6R8F

• Entry DOI: 10.2210/pdb6r8f/pdb
• EMDB information: 4759
• Descriptor: Lys-63-specific deubiquitinase BRCC36, BRISC complex subunit Abraxas 2, Serine hydroxymethyltransferase, mitochondrial, ... (5 entities in total)
• Functional Keywords: complex, deubiquitylation, ubiquitin, immune signalling, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 290687.78

Authors

Walden, M.,Hesketh, E.,Tian, L.,Ranson, N.A.,Greenberg, R.A.,Zeqiraj, E. (deposition date: 2019-04-01, release date: 2019-06-05, Last modification date: 2019-12-18)

• Primary citation: Walden, M.,Tian, L.,Ross, R.L.,Sykora, U.M.,Byrne, D.P.,Hesketh, E.L.,Masandi, S.K.,Cassel, J.,George, R.,Ault, J.R.,El Oualid, F.,Pawlowski, K.,Salvino, J.M.,Eyers, P.A.,Ranson, N.A.,Del Galdo, F.,Greenberg, R.A.,Zeqiraj, E.; Metabolic control of BRISC-SHMT2 assembly regulates immune signalling.; Nature, 570:194-199, 2019; PubMed: 31142841; DOI: 10.1038/s41586-019-1232-1

Experimental method

ELECTRON MICROSCOPY (3.8 Å)