6R8F
Cryo-EM structure of the Human BRISC-SHMT2 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, C) | Lys-63-specific deubiquitinase BRCC36 | polymer | 316 | 36119.9 | 2 | UniProt (P46736) Pfam (PF01398) Pfam (PF18110) | Homo sapiens (Human) | BRCA1-A complex subunit BRCC36,BRCA1/BRCA2-containing complex subunit 3,BRCA1/BRCA2-containing complex subunit 36,BRISC complex subunit BRCC36 |
| 2 | B, E (B, D) | BRISC complex subunit Abraxas 2 | polymer | 267 | 31033.9 | 2 | UniProt (Q15018) Pfam (PF21125) | Homo sapiens (Human) | Abraxas brother protein 1,Protein FAM175B |
| 3 | C, F (K, L) | Serine hydroxymethyltransferase, mitochondrial | polymer | 504 | 56097.9 | 2 | UniProt (P34897) Pfam (PF00464) | Homo sapiens (Human) | SHMT,Glycine hydroxymethyltransferase,Serine methylase |
| 4 | G, H (E, G) | BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2) | polymer | 217 | 22026.7 | 2 | UniProt (Q9NXR7) Pfam (PF06113) | Homo sapiens (Human) | BRCA1-A complex subunit BRE,BRCA1/BRCA2-containing complex subunit 45,Brain and reproductive organ-expressed protein |
| 5 | I, J (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
K, L: 1 - 504 (UniProt: P34897)
E, G: 1 - 131 (UniProt: Q9NXR7)
E, G: 132 - 255 (PDB: 6R8F)
| PDB | External Database | Details |
|---|---|---|
| Thr 285 | Ala 285 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 290557.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 290687.8 |
