2WTK

Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex

Summary for 2WTK

• Entry DOI: 10.2210/pdb2wtk/pdb
• Related: 1UPK 1UPL
• Descriptor: CALCIUM-BINDING PROTEIN 39, STE20-RELATED KINASE ADAPTER PROTEIN ALPHA, SERINE/THREONINE-PROTEIN KINASE 11, ... (6 entities in total)
• Functional Keywords: transferase-metal-binding protein complex, transferase metal-binding protein complex, kinase, nucleus, serine/threonine-protein kinase, pseudokinase, phosphoprotein, signal transduction, transferase, nucleotide-binding, transferase/metal-binding protein
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm (Potential): Q9Y376; Nucleus: Q7RTN6 Q15831
• Total number of polymer chains: 6
• Total formula weight: 234063.08

Authors

Zeqiraj, E.,van Aalten, D.M.F. (deposition date: 2009-09-16, release date: 2009-12-15, Last modification date: 2023-12-20)

• Primary citation: Zeqiraj, E.,Filippi, B.M.,Deak, M.,Alessi, D.R.,Van Aalten, D.M.F.; Structure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation.; Science, 326:1707-, 2009; PubMed: 19892943; DOI: 10.1126/SCIENCE.1178377

Experimental method

X-RAY DIFFRACTION (2.65 Å)