2WTK
Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
Summary for 2WTK
Entry DOI | 10.2210/pdb2wtk/pdb |
Related | 1UPK 1UPL |
Descriptor | CALCIUM-BINDING PROTEIN 39, STE20-RELATED KINASE ADAPTER PROTEIN ALPHA, SERINE/THREONINE-PROTEIN KINASE 11, ... (6 entities in total) |
Functional Keywords | transferase-metal-binding protein complex, transferase metal-binding protein complex, kinase, nucleus, serine/threonine-protein kinase, pseudokinase, phosphoprotein, signal transduction, transferase, nucleotide-binding, transferase/metal-binding protein |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm (Potential): Q9Y376 Nucleus: Q7RTN6 Q15831 |
Total number of polymer chains | 6 |
Total formula weight | 234063.08 |
Authors | Zeqiraj, E.,van Aalten, D.M.F. (deposition date: 2009-09-16, release date: 2009-12-15, Last modification date: 2023-12-20) |
Primary citation | Zeqiraj, E.,Filippi, B.M.,Deak, M.,Alessi, D.R.,Van Aalten, D.M.F. Structure of the Lkb1-Strad-Mo25 Complex Reveals an Allosteric Mechanism of Kinase Activation. Science, 326:1707-, 2009 Cited by PubMed: 19892943DOI: 10.1126/SCIENCE.1178377 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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