2WTK
Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007165 | biological_process | signal transduction |
| A | 0014823 | biological_process | response to activity |
| A | 0019900 | molecular_function | kinase binding |
| A | 0030018 | cellular_component | Z disc |
| A | 0030295 | molecular_function | protein kinase activator activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071476 | biological_process | cellular hypotonic response |
| A | 0097066 | biological_process | response to thyroid hormone |
| A | 0120283 | molecular_function | protein serine/threonine kinase binding |
| A | 1901380 | biological_process | negative regulation of potassium ion transmembrane transport |
| A | 1902554 | cellular_component | serine/threonine protein kinase complex |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| C | 0001558 | biological_process | regulation of cell growth |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0030010 | biological_process | establishment of cell polarity |
| C | 0030295 | molecular_function | protein kinase activator activity |
| C | 0042593 | biological_process | glucose homeostasis |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0007165 | biological_process | signal transduction |
| D | 0014823 | biological_process | response to activity |
| D | 0019900 | molecular_function | kinase binding |
| D | 0030018 | cellular_component | Z disc |
| D | 0030295 | molecular_function | protein kinase activator activity |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0034774 | cellular_component | secretory granule lumen |
| D | 0035556 | biological_process | intracellular signal transduction |
| D | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071476 | biological_process | cellular hypotonic response |
| D | 0097066 | biological_process | response to thyroid hormone |
| D | 0120283 | molecular_function | protein serine/threonine kinase binding |
| D | 1901380 | biological_process | negative regulation of potassium ion transmembrane transport |
| D | 1902554 | cellular_component | serine/threonine protein kinase complex |
| D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| E | 0004672 | molecular_function | protein kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0006468 | biological_process | protein phosphorylation |
| E | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| F | 0001558 | biological_process | regulation of cell growth |
| F | 0004672 | molecular_function | protein kinase activity |
| F | 0004674 | molecular_function | protein serine/threonine kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0006468 | biological_process | protein phosphorylation |
| F | 0030010 | biological_process | establishment of cell polarity |
| F | 0030295 | molecular_function | protein kinase activator activity |
| F | 0042593 | biological_process | glucose homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ANP B 432 |
| Chain | Residue |
| B | ILE75 |
| B | THR147 |
| B | SER148 |
| B | MET150 |
| B | SER154 |
| B | ASP157 |
| B | LYS197 |
| B | SER199 |
| B | HIS200 |
| B | ARG215 |
| B | LYS239 |
| B | GLY76 |
| B | LYS77 |
| B | GLY78 |
| B | PHE79 |
| B | MET83 |
| B | VAL85 |
| B | THR98 |
| B | ARG100 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ANP C 2 |
| Chain | Residue |
| C | GLY56 |
| C | GLY58 |
| C | SER59 |
| C | TYR60 |
| C | GLY61 |
| C | VAL63 |
| C | ALA76 |
| C | LYS78 |
| C | MET129 |
| C | GLU130 |
| C | CYS132 |
| C | GLU138 |
| C | LEU183 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 342 |
| Chain | Residue |
| D | ARG152 |
| D | ARG194 |
| F | LYS108 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ANP E 432 |
| Chain | Residue |
| E | ILE75 |
| E | GLY76 |
| E | LYS77 |
| E | GLY78 |
| E | PHE79 |
| E | MET83 |
| E | VAL85 |
| E | THR98 |
| E | ARG100 |
| E | THR147 |
| E | SER148 |
| E | MET150 |
| E | SER154 |
| E | ASP157 |
| E | LYS197 |
| E | SER199 |
| E | HIS200 |
| E | ARG215 |
| E | LYS239 |
| E | PHE415 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ANP F 4 |
| Chain | Residue |
| F | GLY56 |
| F | GLY58 |
| F | SER59 |
| F | TYR60 |
| F | GLY61 |
| F | ALA76 |
| F | LYS78 |
| F | MET129 |
| F | GLU130 |
| F | CYS132 |
| F | GLU138 |
| F | LEU183 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSYGKVKeVldsetlcr..........RAVK |
| Chain | Residue | Details |
| C | LEU55-LYS78 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHkDIKpgNLLL |
| Chain | Residue | Details |
| C | ILE172-LEU184 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by LKB1","evidences":[{"source":"PubMed","id":"12805220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18687677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"11430832","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9WTK7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"12805220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 45 |
| Details | Region: {"description":"Sufficient for interaction with SIRT1","evidences":[{"source":"PubMed","id":"18687677","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | GLY180 | |
| C | ASP176 |
| site_id | CSA10 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | ASN181 | |
| F | LYS178 | |
| F | ASP176 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | GLY180 | |
| F | ASP176 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | LYS178 | |
| C | ASP176 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | LYS178 | |
| F | ASP176 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | SER195 | |
| B | LYS197 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| E | SER195 | |
| E | LYS197 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | SER216 | |
| C | LYS178 | |
| C | ASP176 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| F | SER216 | |
| F | LYS178 | |
| F | ASP176 |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| C | ASN181 | |
| C | LYS178 | |
| C | ASP176 |
