2WTK
Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D | CALCIUM-BINDING PROTEIN 39 | polymer | 341 | 39922.9 | 2 | UniProt (Q9Y376) Pfam (PF08569) In PDB | HOMO SAPIENS (HUMAN) | MO25ALPHA, PROTEIN MO25 |
| 2 | B, E | STE20-RELATED KINASE ADAPTER PROTEIN ALPHA | polymer | 373 | 41748.4 | 2 | UniProt (Q7RTN6) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | STRADALPHA, STRAD ALPHA, STE20-RELATED ADAPTER PROTEIN, SEROLOGICALLY DEFINED BREAST CANCER ANTIGEN NY-BR-96 |
| 3 | C, F | SERINE/THREONINE-PROTEIN KINASE 11 | polymer | 305 | 34299.8 | 2 | UniProt (Q15831) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | LKB1, SERINE/THREONINE-PROTEIN KINASE LKB1, RENAL CARCINOMA ANTIGEN NY-REN-19 |
| 4 | B, C, E, F | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
| 5 | D | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
C, F: 43 - 347 (UniProt: Q15831)
| PDB | External Database | Details |
|---|---|---|
| Ala 194 | Asp 194 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 231942.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2120.8 | |
| All* | Total formula weight | 234063.1 |
