4O1O
Crystal Structure of RNase L in complex with 2-5A
Summary for 4O1O
Entry DOI | 10.2210/pdb4o1o/pdb |
Related | 4O1P |
Descriptor | Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (2 entities in total) |
Functional Keywords | ankyrin repeat-kinase-rnase, 2-5a, transferase, hydrolase |
Biological source | Sus scrofa (pigs,swine,wild boar) |
Total number of polymer chains | 4 |
Total formula weight | 329973.72 |
Authors | Huang, H.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F. (deposition date: 2013-12-16, release date: 2014-02-05, Last modification date: 2023-09-20) |
Primary citation | Huang, H.,Zeqiraj, E.,Dong, B.,Jha, B.K.,Duffy, N.M.,Orlicky, S.,Thevakumaran, N.,Talukdar, M.,Pillon, M.C.,Ceccarelli, D.F.,Wan, L.C.,Juang, Y.C.,Mao, D.Y.,Gaughan, C.,Brinton, M.A.,Perelygin, A.A.,Kourinov, I.,Guarne, A.,Silverman, R.H.,Sicheri, F. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol.Cell, 53:221-234, 2014 Cited by PubMed: 24462203DOI: 10.1016/j.molcel.2013.12.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.27 Å) |
Structure validation
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