3QX3
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![BU of 3qx3 by Molmil](/molmil-images/mine/3qx3) | Human topoisomerase IIbeta in complex with DNA and etoposide | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | 著者 | Wu, C.C, Li, T.K, Farh, L, Lin, L.Y, Lin, T.S, Yu, Y.J, Yen, T.J, Chiang, C.W, Chan, N.L. | 登録日 | 2011-03-01 | 公開日 | 2011-07-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.162 Å) | 主引用文献 | Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide Science, 333, 2011
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4G0W
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![BU of 4g0w by Molmil](/molmil-images/mine/4g0w) | Human topoisomerase iibeta in complex with DNA and ametantrone | 分子名称: | 1,4-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | 著者 | Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L. | 登録日 | 2012-07-10 | 公開日 | 2013-07-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | 主引用文献 | On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41, 2013
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4G0U
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![BU of 4g0u by Molmil](/molmil-images/mine/4g0u) | Human topoisomerase IIbeta in complex with DNA and amsacrine | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | 著者 | Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L. | 登録日 | 2012-07-10 | 公開日 | 2013-07-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41, 2013
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4J3N
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![BU of 4j3n by Molmil](/molmil-images/mine/4j3n) | Human Topoisomerase Iibeta in complex with DNA | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | 著者 | Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L. | 登録日 | 2013-02-06 | 公開日 | 2013-10-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41, 2013
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4G0V
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![BU of 4g0v by Molmil](/molmil-images/mine/4g0v) | Human topoisomerase iibeta in complex with DNA and mitoxantrone | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | 著者 | Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L. | 登録日 | 2012-07-10 | 公開日 | 2013-07-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.548 Å) | 主引用文献 | On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41, 2013
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6IID
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![BU of 6iid by Molmil](/molmil-images/mine/6iid) | Human EXOG-H140A in complex with RNA-DNA chimeric duplex | 分子名称: | DNA (5'-D(*CP*GP*TP*GP*AP*CP*AP*TP*CP*CP*CP*G)-3'), DNA/RNA (5'-R(P*CP*GP*GP*GP*A)-D(P*T)-R(P*G)-D(P*T)-R(P*CP*AP*CP*G)-3'), MAGNESIUM ION, ... | 著者 | Wu, C.C, Lin, J.L.J, Yuan, H.S. | 登録日 | 2018-10-04 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.986 Å) | 主引用文献 | A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res., 47, 2019
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5ZKI
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![BU of 5zki by Molmil](/molmil-images/mine/5zki) | Human EXOG-H140A in complex with duplex DNA | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*GP*GP*AP*TP*AP*TP*CP*CP*CP*G)-3'), MAGNESIUM ION, ... | 著者 | Wu, C.C, Lin, J.L.J, Yuan, H.S. | 登録日 | 2018-03-24 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.321 Å) | 主引用文献 | A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res., 47, 2019
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5ZKJ
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![BU of 5zkj by Molmil](/molmil-images/mine/5zkj) | Human EXOG-H140A in complex with RNA/DNA hybrid duplex | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*GP*AP*CP*AP*TP*CP*CP*CP*G)-3'), MAGNESIUM ION, ... | 著者 | Wu, C.C, Lin, J.L.J, Yuan, H.S. | 登録日 | 2018-03-24 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | 主引用文献 | A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res., 47, 2019
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8XA9
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![BU of 8xa9 by Molmil](/molmil-images/mine/8xa9) | Human MGME1 in complex with 5'-overhang DNA | 分子名称: | CALCIUM ION, DNA (11-MER), DNA (18-MER), ... | 著者 | Wu, C.C, Mao, E.Y.C. | 登録日 | 2023-12-03 | 公開日 | 2024-03-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural basis of how MGME1 processes DNA 5' ends to maintain mitochondrial genome integrity. Nucleic Acids Res., 52, 2024
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5GWJ
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![BU of 5gwj by Molmil](/molmil-images/mine/5gwj) | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | 著者 | Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L. | 登録日 | 2016-09-12 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.566 Å) | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45, 2017
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7B7D
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![BU of 7b7d by Molmil](/molmil-images/mine/7b7d) | Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs | 分子名称: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | 著者 | Ranjan, N, Pochopien, A.A, Wu, C.C, Beckert, B, Blanchet, S, Green, R, Rodnina, M.V, Wilson, D.N. | 登録日 | 2020-12-10 | 公開日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | eEF3 promotes late stages of tRNA translocation including E-tRNA release from the ribosome To Be Published
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5GWI
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![BU of 5gwi by Molmil](/molmil-images/mine/5gwi) | Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873R | 分子名称: | DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... | 著者 | Wang, Y.R, Chen, S.F, Wu, C.C, Chan, N.L. | 登録日 | 2016-09-12 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.737 Å) | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45, 2017
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5GWK
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![BU of 5gwk by Molmil](/molmil-images/mine/5gwk) | Human topoisomerase IIalpha in complex with DNA and etoposide | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... | 著者 | Wang, Y.R, Wu, C.C, Chan, N.L. | 登録日 | 2016-09-12 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.152 Å) | 主引用文献 | Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45, 2017
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5ZRF
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![BU of 5zrf by Molmil](/molmil-images/mine/5zrf) | Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA topoisomerase 2-beta, ... | 著者 | Chen, S.F, Wang, Y.R, Wu, C.C, Chan, N.L. | 登録日 | 2018-04-24 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. Nat Commun, 9, 2018
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4M27
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![BU of 4m27 by Molmil](/molmil-images/mine/4m27) | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and L-Arg | 分子名称: | ARGININE, FE (III) ION, L-arginine beta-hydroxylase, ... | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2E
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![BU of 4m2e by Molmil](/molmil-images/mine/4m2e) | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and L-homoarginine | 分子名称: | FE (III) ION, L-HOMOARGININE, L-arginine beta-hydroxylase | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2J
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![BU of 4m2j by Molmil](/molmil-images/mine/4m2j) | Crystal structure of PLP-dependent cyclase OrfR in complex with Au | 分子名称: | Aminotransferase, GOLD ION, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2C
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![BU of 4m2c by Molmil](/molmil-images/mine/4m2c) | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and D-Arg | 分子名称: | D-ARGININE, FE (III) ION, L-arginine beta-hydroxylase | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2G
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![BU of 4m2g by Molmil](/molmil-images/mine/4m2g) | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe, succinate, and (3R,4R)-dihydroxy-L-Arg | 分子名称: | FE (III) ION, L-arginine beta-hydroxylase, SUCCINIC ACID, ... | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M25
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![BU of 4m25 by Molmil](/molmil-images/mine/4m25) | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and alpha-ketoglutaric acid | 分子名称: | 2-OXOGLUTARIC ACID, FE (III) ION, L-arginine beta-hydroxylase | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2F
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![BU of 4m2f by Molmil](/molmil-images/mine/4m2f) | Crystal structure of non-heme iron oxygenase OrfP in complex with Fe and L-canavanine | 分子名称: | FE (III) ION, L-CANAVANINE, L-arginine beta-hydroxylase | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2K
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![BU of 4m2k by Molmil](/molmil-images/mine/4m2k) | Crystal structure of PLP-dependent cyclase OrfR in complex with PLP | 分子名称: | Aminotransferase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M23
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![BU of 4m23 by Molmil](/molmil-images/mine/4m23) | Crystal structure of non-heme iron oxygenase OrfP | 分子名称: | L-arginine beta-hydroxylase | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4M2M
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![BU of 4m2m by Molmil](/molmil-images/mine/4m2m) | Crystal structure of PLP-dependent cyclase OrfR in complex with PLP-L-Arg | 分子名称: | ARGININE, Aminotransferase, PYRIDOXAL-5'-PHOSPHATE | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-08-05 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angew.Chem.Int.Ed.Engl., 53, 2014
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4NE0
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![BU of 4ne0 by Molmil](/molmil-images/mine/4ne0) | Crystal structure of non-heme iron oxygenase OrfP D157A mutant in complex with (3S)-hydroxy-L-Arg | 分子名称: | (2S,3S)-3-HYDROXYARGININE, FE (III) ION, L-arginine beta-hydroxylase, ... | 著者 | Chang, C.Y, Liu, Y.C, Lyu, S.Y, Wu, C.C, Li, T.L. | 登録日 | 2013-10-28 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms Angew.Chem.Int.Ed.Engl., 53, 2014
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