5GWJ
Structure of a Human topoisomerase IIbeta fragment in complex with DNA and E7873S
Summary for 5GWJ
Entry DOI | 10.2210/pdb5gwj/pdb |
Related | 5GWI 5GWK |
Descriptor | DNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), ... (7 entities in total) |
Functional Keywords | type ii topoisomerase, anti-cancer drug, topoii cleavage complex, isomerase-dna complex, isomerase-dna-isomerase inhibitor complex, isomerase/dna/isomerase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q02880 |
Total number of polymer chains | 6 |
Total formula weight | 199160.84 |
Authors | Wang, Y.R.,Chen, S.F.,Wu, C.C.,Chan, N.L. (deposition date: 2016-09-12, release date: 2017-08-23, Last modification date: 2023-11-08) |
Primary citation | Wang, Y.R.,Chen, S.F.,Wu, C.C.,Liao, Y.W.,Lin, T.S.,Liu, K.T.,Chen, Y.S.,Li, T.K.,Chien, T.C.,Chan, N.L. Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry Nucleic Acids Res., 45:10861-10871, 2017 Cited by PubMed: 28977631DOI: 10.1093/nar/gkx742 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.566 Å) |
Structure validation
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