4PB5
 
 | | D-threo-3-hydroxyaspartate dehydratase H351A mutant complexed with L-erythro-3-hydroxyaspartate | | 分子名称: | (3R)-3-hydroxy-L-aspartic acid, D-threo-3-hydroxyaspartate dehydratase, GLYCEROL, ... | | 著者 | Yasutake, Y, Matsumoto, Y, Wada, M. | | 登録日 | 2014-04-11 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate.
Appl.Microbiol.Biotechnol., 99, 2015
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4PB3
 | | D-threo-3-hydroxyaspartate dehydratase H351A mutant | | 分子名称: | D-threo-3-hydroxyaspartate dehydratase, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Yasutake, Y, Matsumoto, Y, Wada, M. | | 登録日 | 2014-04-11 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate.
Appl.Microbiol.Biotechnol., 99, 2015
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4PB4
 | | D-threo-3-hydroxyaspartate dehydratase H351A mutant complexed with 2-amino maleic acid | | 分子名称: | 2-amino maleic acid, D-threo-3-hydroxyaspartate dehydratase, MAGNESIUM ION, ... | | 著者 | Yasutake, Y, Matsumoto, Y, Wada, M. | | 登録日 | 2014-04-11 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate.
Appl.Microbiol.Biotechnol., 99, 2015
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3WQG
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1IY8
 | | Crystal Structure of Levodione Reductase | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, LEVODIONE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Sogabe, S, Fukami, T, Shiratori, Y, Yoshizumi, A, Wada, M. | | 登録日 | 2002-07-25 | | 公開日 | 2003-05-27 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The Crystal Structure and Stereospecificity of Levodione Reductase from Corynebacterium aquaticum M-13
J.BIOL.CHEM., 278, 2003
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3WQE
 | | D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23 complexed with D-allothreonine | | 分子名称: | D-allothreonine, D-threo-3-hydroxyaspartate dehydratase, MAGNESIUM ION, ... | | 著者 | Yasutake, Y, Matsumoto, Y, Wada, M. | | 登録日 | 2014-01-25 | | 公開日 | 2015-01-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate
Appl.Microbiol.Biotechnol., 99, 2015
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3WQD
 | | D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23 complexed with D-erythro-3-hydroxyaspartate | | 分子名称: | (3S)-3-hydroxy-D-aspartic acid, D-threo-3-hydroxyaspartate dehydratase, MAGNESIUM ION, ... | | 著者 | Yasutake, Y, Matsumoto, Y, Wada, M. | | 登録日 | 2014-01-25 | | 公開日 | 2015-01-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate
Appl.Microbiol.Biotechnol., 99, 2015
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3WQC
 | | D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23 | | 分子名称: | CHLORIDE ION, D-threo-3-hydroxyaspartate dehydratase, GLYCEROL, ... | | 著者 | Yasutake, Y, Matsumoto, Y, Wada, M. | | 登録日 | 2014-01-25 | | 公開日 | 2015-01-28 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate
Appl.Microbiol.Biotechnol., 99, 2015
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3WQF
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5ZV2
 | | FGFR-1 in complex with ligand lenvatinib | | 分子名称: | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, Fibroblast growth factor receptor 1 | | 著者 | Matsuki, M, Hoshi, T, Yamamoto, Y, Ikemori-Kawada, M, Minoshima, Y, Funahashi, Y, Matsui, J. | | 登録日 | 2018-05-09 | | 公開日 | 2018-07-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models.
Cancer Med, 7, 2018
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1D7N
 | | SOLUTION STRUCTURE ANALYSIS OF THE MASTOPARAN WITH DETERGENTS | | 分子名称: | PROTEIN (WASP VENOM PEPTIDE (MASTOPARAN)) | | 著者 | Hori, Y, Demura, M, Iwadate, M, Niidome, T, Aoyagi, H, Asakura, T. | | 登録日 | 1999-10-19 | | 公開日 | 2001-06-20 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Interaction of mastoparan with membranes studied by 1H-NMR spectroscopy in detergent micelles and by solid-state 2H-NMR and 15N-NMR spectroscopy in oriented lipid bilayers.
Eur.J.Biochem., 268, 2001
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3WZE
 | | KDR in complex with ligand sorafenib | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ACETATE ION, ... | | 著者 | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | | 登録日 | 2014-09-24 | | 公開日 | 2015-05-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS MED.CHEM.LETT., 6, 2015
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3WZD
 | | KDR in complex with ligand lenvatinib | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, ... | | 著者 | Okamoto, K, Ikemori_Kawada, M, Inoue, A, Matsui, J. | | 登録日 | 2014-09-24 | | 公開日 | 2015-05-27 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
ACS MED.CHEM.LETT., 6, 2015
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7ATS
 | | The LIMK1 Kinase Domain Bound To LIJTF500127 | | 分子名称: | LIM domain kinase 1, N-[3-[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]benzenesulfonamide | | 著者 | Mathea, S, Chatterjee, D, Preuss, F, Yamamoto, S, Tawada, M, Nomura, I, Takagi, T, Ahmed, M, Little, W, Mueller-Knapp, S, Knapp, S. | | 登録日 | 2020-10-30 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The LIMK1 Kinase Domain Bound To LIJTF500127
To Be Published
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7ATU
 | | The LIMK1 Kinase Domain Bound To LIJTF500025 | | 分子名称: | (S)-2-benzyl-6-(8-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide, LIM domain kinase 1 | | 著者 | Mathea, S, Chatterjee, D, Preuss, F, Yamamoto, S, Tawada, M, Nomura, I, Takagi, T, Ahmed, M, Little, W, Mueller-Knapp, S, Knapp, S. | | 登録日 | 2020-10-30 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The LIMK1 Kinase Domain Bound To LIJTF500025
To Be Published
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3VW8
 | | Crystal structure of human c-Met kinase domain with its inhibitor | | 分子名称: | CHLORIDE ION, Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | | 著者 | Matsumoto, S, Miyamoto, N, Hirayama, T, Oki, H, Okada, K, Tawada, M, Iwata, H, Miki, H, Nakamura, K, Hori, A, Imamura, S. | | 登録日 | 2012-08-08 | | 公開日 | 2013-08-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors.
Bioorg.Med.Chem., 21, 2013
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3VHK
 | | Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder | | 分子名称: | 1,2-ETHANEDIOL, Vascular endothelial growth factor receptor 2, {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol | | 著者 | Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. | | 登録日 | 2011-08-25 | | 公開日 | 2012-09-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.
ACS MED.CHEM.LETT., 3, 2012
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3VID
 | | Crystal structure of human VEGFR2 kinase domain with Compound A. | | 分子名称: | 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole, Vascular endothelial growth factor receptor 2 | | 著者 | Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. | | 登録日 | 2011-09-29 | | 公開日 | 2012-08-15 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.
ACS MED.CHEM.LETT., 3, 2012
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5T4S
 | | Novel Approach of Fragment-Based Lead Discovery applied to Renin Inhibitors | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-chloro-N-[(furan-2-yl)methyl]pyrazin-2-amine, ... | | 著者 | Snell, G.P, Behnke, C.A, Okada, K, Oki, H, Sang, B.C, Lane, W. | | 登録日 | 2016-08-30 | | 公開日 | 2016-10-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Novel approach of fragment-based lead discovery applied to renin inhibitors.
Bioorg.Med.Chem., 24, 2016
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7K41
 | | Bacterial O-GlcNAcase (OGA) with compound | | 分子名称: | 1,2-ETHANEDIOL, 4-(4-methylpiperidin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine, ACETATE ION, ... | | 著者 | Lane, W, Tjhen, R, Snell, G, Sang, B. | | 登録日 | 2020-09-14 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of a Novel and Brain-Penetrant O -GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
J.Med.Chem., 64, 2021
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6LBH
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5H36
 | | Crystal structures of the TRIC trimeric intracellular cation channel orthologue from Rhodobacter sphaeroides | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Uncharacterized protein TRIC | | 著者 | Kasuya, G, Hiraizumi, M, Hattori, M, Nureki, O. | | 登録日 | 2016-10-20 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.409 Å) | | 主引用文献 | Crystal structures of the TRIC trimeric intracellular cation channel orthologues
Cell Res., 26, 2016
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5H35
 | | Crystal structures of the TRIC trimeric intracellular cation channel orthologue from Sulfolobus solfataricus | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Fab Heavy Chain, Fab Light Chain, ... | | 著者 | Kasuya, G, Hiraizumi, M, Hattori, M, Nureki, O. | | 登録日 | 2016-10-20 | | 公開日 | 2017-01-11 | | 最終更新日 | 2020-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.642 Å) | | 主引用文献 | Crystal structures of the TRIC trimeric intracellular cation channel orthologues
Cell Res., 26, 2016
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1R5B
 | | Crystal structure analysis of sup35 | | 分子名称: | Eukaryotic peptide chain release factor GTP-binding subunit | | 著者 | Kong, C, Song, H. | | 登録日 | 2003-10-10 | | 公開日 | 2004-05-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structure and functional analysis of the eukaryotic class II release factor eRF3 from S. pombe
Mol.Cell, 14, 2004
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8WAF
 | | Crystal structure of the C-terminal fragment (residues 756-982 with the C864S mutation) of Arabidopsis thaliana CHUP1 | | 分子名称: | Protein CHUP1, chloroplastic | | 著者 | Shimada, A, Takano, A, Nakamura, Y, Kohda, D. | | 登録日 | 2023-09-07 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | CHLOROPLAST UNUSUAL POSITIONING 1 is a plant-specific actin polymerization factor regulating chloroplast movement.
Plant Cell, 36, 2024
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