3VHK

Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder

Summary for 3VHK

Entry DOI	10.2210/pdb3vhk/pdb
Descriptor	Vascular endothelial growth factor receptor 2, {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	vegfr2, kinase domain, complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains	1
Total formula weight	42162.22
Authors	Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Hixon, M.S.,Kimura, H.,Miki, H. (deposition date: 2011-08-25, release date: 2012-09-05, Last modification date: 2024-03-20)
Primary citation	Iwata, H.,Oki, H.,Okada, K.,Takagi, T.,Tawada, M.,Miyazaki, Y.,Imamura, S.,Hori, A.,Lawson, J.D.,Hixon, M.S.,Kimura, H.,Miki, H. A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3:342-346, 2012 Cited by PubMed: 24900475 DOI: 10.1021/ml3000403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation