5FD9
 
 | | X-ray Crystal Structure of ESCRT-III Snf7 core domain (conformation B) | | 分子名称: | Vacuolar-sorting protein SNF7 | | 著者 | Tang, S, Henne, W.M, Borbat, P.P, Buchkovich, N.J, Freed, J.H, Mao, Y, Fromme, J.C, Emr, S.D. | | 登録日 | 2015-12-15 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments.
Elife, 4, 2015
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7UX0
 | | Human Sperm TMEM95 Ectodomain | | 分子名称: | Sperm-egg fusion protein TMEM95, TRIETHYLENE GLYCOL, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2022-05-04 | | 公開日 | 2022-10-12 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Human sperm TMEM95 binds eggs and facilitates membrane fusion.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6UMV
 | | Human apo PD-1 double mutant | | 分子名称: | CHLORIDE ION, Programmed cell death protein 1 | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2019-10-10 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.424 Å) | | 主引用文献 | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMT
 | | High-affinity human PD-1 PD-L2 complex | | 分子名称: | MAGNESIUM ION, Programmed cell death 1 ligand 2, Programmed cell death protein 1 | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2019-10-10 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.986 Å) | | 主引用文献 | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6UMU
 | | Human apo PD-1 triple mutant | | 分子名称: | CHLORIDE ION, Programmed cell death protein 1 | | 著者 | Tang, S, Kim, P.S. | | 登録日 | 2019-10-10 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.183 Å) | | 主引用文献 | A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6CYJ
 | | Mycobacterium tuberculosis transcriptional regulator | | 分子名称: | HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER, SUCCINYL-COENZYME A | | 著者 | Tang, S, Sacchettini, J. | | 登録日 | 2018-04-05 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | | 主引用文献 | Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.
Nucleic Acids Res., 47, 2019
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6CZ6
 | | Mycobacterium tuberculosis transcriptional regulator | | 分子名称: | COENZYME A, HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER | | 著者 | Tang, S, Sacchettini, J. | | 登録日 | 2018-04-08 | | 公開日 | 2019-04-17 | | 最終更新日 | 2019-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.
Nucleic Acids Res., 47, 2019
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6D2S
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6CYY
 | | Mycobacterium tuberculosis transcriptional regulator | | 分子名称: | COENZYME A, HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER | | 著者 | Tang, S, Sacchettini, J. | | 登録日 | 2018-04-07 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.506 Å) | | 主引用文献 | Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.
Nucleic Acids Res., 47, 2019
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6D8I
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6D8J
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5FD7
 | | X-ray Crystal Structure of ESCRT-III Snf7 core domain (conformation A) | | 分子名称: | Vacuolar-sorting protein SNF7 | | 著者 | Tang, S, Henne, W.M, Borbat, P.P, Buchkovich, N.J, Freed, J.H, Mao, Y, Fromme, J.C, Emr, S.D. | | 登録日 | 2015-12-15 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments.
Elife, 4, 2015
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7OEX
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7Q8T
 | | Crystal structure of NAMPT bound to ligand TSY535(compound 9a) | | 分子名称: | Nicotinamide phosphoribosyltransferase, SULFATE ION, [(2~{R},3~{S},4~{R},5~{S})-3,4-bis(oxidanyl)-5-[4-[[[4-(phenylsulfonyl)phenyl]carbamoylamino]methyl]phenyl]oxolan-2-yl]methyl dihydrogen phosphate | | 著者 | Kraemer, A, Tang, S, Butterworth, S, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators.
Acta Pharm Sin B, 13, 2023
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6UX6
 | | Cruzain covalently bound by a vinylsulfone compound | | 分子名称: | Cruzipain, GLYCEROL, Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-phenyl-4-(phenylsulfonyl)butan-2-yl]-L-phenylalaninamide | | 著者 | Zhai, X, Tang, S, Chenna, B.C, Meek, T.D, Sacchettini, J.C. | | 登録日 | 2019-11-06 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Cruzain covalently bound by a vinylsulfone compound
To Be Published
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8F3B
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8F3A
 | | HIV-1 gp41 coiled-coil pocket IQN17 | | 分子名称: | ACETIC ACID, CHLORIDE ION, IQN17 | | 著者 | Bruun, T.U.J, Tang, S, Fernandez, D, Kim, P.S. | | 登録日 | 2022-11-09 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies.
J.Biol.Chem., 299, 2023
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1XMG
 | | Crystal structure of apo methane monooxygenase hydroxylase from M. capsulatus (Bath) | | 分子名称: | CALCIUM ION, Methane monooxygenase component A alpha chain, Methane monooxygenase component A beta chain, ... | | 著者 | Sazinsky, M.H, Merkx, M, Cadieux, E, Tang, S, Lippard, S.J. | | 登録日 | 2004-10-02 | | 公開日 | 2005-01-18 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Preparation and X-ray Structures of Metal-Free, Dicobalt and Dimanganese Forms of Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath)
Biochemistry, 43, 2004
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1XMF
 | | Structure of Mn(II)-Soaked Apo Methane Monooxygenase Hydroxylase Crystals from M. capsulatus (Bath) | | 分子名称: | CALCIUM ION, MANGANESE (II) ION, Methane monooxygenase component A alpha chain, ... | | 著者 | Sazinsky, M.H, Merkx, M, Cadieux, E, Tang, S, Lippard, S.J. | | 登録日 | 2004-10-02 | | 公開日 | 2005-01-18 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Preparation and X-ray Structures of Metal-Free, Dicobalt and Dimanganese Forms of Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath)
Biochemistry, 43, 2004
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1XMH
 | | Structure of Co(II) reconstituted methane monooxygenase hydroxylase from M. capsulatus (Bath) | | 分子名称: | COBALT (II) ION, Methane monooxygenase component A alpha chain, Methane monooxygenase component A beta chain, ... | | 著者 | Sazinsky, M.H, Merkx, M, Cadieux, E, Tang, S, Lippard, S.J. | | 登録日 | 2004-10-02 | | 公開日 | 2005-01-18 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Preparation and X-ray Structures of Metal-Free, Dicobalt and Dimanganese Forms of Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath)
Biochemistry, 43, 2004
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5XDP
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8J22
 | | Cryo-EM structure of FFAR2 complex bound with TUG-1375 | | 分子名称: | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | | 登録日 | 2023-04-14 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
Cell Res., 34, 2024
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8J21
 | | Cryo-EM structure of FFAR3 complex bound with butyrate acid | | 分子名称: | Free fatty acid receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | | 登録日 | 2023-04-14 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
Cell Res., 34, 2024
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8J20
 | | Cryo-EM structure of FFAR3 bound with valeric acid and AR420626 | | 分子名称: | (4R)-N-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide, Free fatty acid receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | | 登録日 | 2023-04-14 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
Cell Res., 34, 2024
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8J24
 | | Cryo-EM structure of FFAR2 complex bound with acetic acid | | 分子名称: | ACETATE ION, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Tai, L, Li, F, Tang, W, Sun, X, Wang, J. | | 登録日 | 2023-04-14 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3.
Cell Res., 34, 2024
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