6GEV

Mineralocorticoid receptor in complex with (s)-13

Summary for 6GEV

DescriptorMineralocorticoid receptor, Nuclear receptor coactivator 1, GLYCEROL, ... (5 entities in total)
Functional Keywordsmineralocorticoid receptor, nuclear hormone receptor, steroid receptor, ligand complex, peptide complex, signaling protein, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight37219.39
Authors
Edman, K.,Aagaard, A.,Tangefjord, S. (deposition date: 2018-04-27, release date: 2019-01-09)
Primary citation
Granberg, K.,Yuan, Z.Q.,Lindmark, B.,Edman, K.,Kajanus, J.,Hogner, A.,Malmgren, M.,O'Mahony, G.,Nordqvist, A.,Lindberg, J.,Tangefjord, S.,Kossenjans, M.,Lofberg, C.,Branalt, J.,Liu, D.,Selmi, N.,Nikitidis, G.,Nordberg, P.,Hayen, A.,Aagaard, A.,Hansson, E.,Hermansson, M.,Ivarsson, I.,Jansson Lofmark, R.,Karlsson, U.,Johansson, U.,William-Olsson, L.,Hartleib-Geschwindner, J.,Bamberg, K.
Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection.
J. Med. Chem., 2018
PubMed: 30596500 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.8b01523
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.54 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.189100 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6gev
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Molmil generated image of 6gev
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Molmil generated image of 6gev
rotated about y axis by 90°
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