1TAD
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![BU of 1tad by Molmil](/molmil-images/mine/1tad) | GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- | 分子名称: | CACODYLATE ION, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Sondek, J, Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. | 登録日 | 1995-01-05 | 公開日 | 1995-05-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature, 372, 1994
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4K45
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2ZKM
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![BU of 2zkm by Molmil](/molmil-images/mine/2zkm) | Crystal Structure of Phospholipase C Beta 2 | 分子名称: | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, CALCIUM ION | 著者 | Hicks, S.N, Jezyk, M.R, Gershberg, S, Seifert, J.P, Harden, T.K, Sondek, J. | 登録日 | 2008-03-26 | 公開日 | 2008-08-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | General and versatile autoinhibition of PLC isozymes Mol.Cell, 31, 2008
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1GOT
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![BU of 1got by Molmil](/molmil-images/mine/1got) | HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS | 分子名称: | GT-ALPHA/GI-ALPHA CHIMERA, GT-BETA, GT-GAMMA, ... | 著者 | Lambright, D.G, Sondek, J, Bohm, A, Skiba, N.P, Hamm, H.E, Sigler, P.B. | 登録日 | 1996-08-07 | 公開日 | 1997-03-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The 2.0 A crystal structure of a heterotrimeric G protein. Nature, 379, 1996
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7T8T
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![BU of 7t8t by Molmil](/molmil-images/mine/7t8t) | CryoEM structure of PLCg1 | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION | 著者 | Endo-Streeter, S, Sondek, J. | 登録日 | 2021-12-17 | 公開日 | 2022-12-21 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | CryoEM structure of PLCg1 To Be Published
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6PBC
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![BU of 6pbc by Molmil](/molmil-images/mine/6pbc) | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION | 著者 | Hajicek, N, Sondek, J. | 登録日 | 2019-06-13 | 公開日 | 2020-01-08 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. Elife, 8, 2019
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2FJU
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![BU of 2fju by Molmil](/molmil-images/mine/2fju) | Activated Rac1 bound to its effector phospholipase C beta 2 | 分子名称: | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CALCIUM ION, ... | 著者 | Jezyk, M.R, Snyder, J.T, Harden, T.K, Sondek, J. | 登録日 | 2006-01-03 | 公開日 | 2006-11-21 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Nat.Struct.Mol.Biol., 13, 2006
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7SQ2
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![BU of 7sq2 by Molmil](/molmil-images/mine/7sq2) | Reprocessed and refined structure of Phospholipase C-beta and Gq signaling complex | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, ACETATE ION, CALCIUM ION, ... | 著者 | Endo-Streeter, S.T, Sondek, J, Harden, T.K. | 登録日 | 2021-11-04 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Kinetic Scaffolding Mediated by a Phospholipase C-{beta} and Gq Signaling Complex Science, 330, 2010
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1XO5
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![BU of 1xo5 by Molmil](/molmil-images/mine/1xo5) | Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein | 分子名称: | CALCIUM ION, Calcium and integrin-binding protein 1 | 著者 | Gentry, H.R, Singer, A.U, Betts, L, Yang, C, Ferrara, J.D, Parise, L.V, Sondek, J. | 登録日 | 2004-10-05 | 公開日 | 2004-12-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins J.Biol.Chem., 280, 2005
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1Y3A
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![BU of 1y3a by Molmil](/molmil-images/mine/1y3a) | Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | 著者 | Johnston, C.A, Willard, F.S, Jezyk, M.R, Fredericks, Z, Bodor, E.T, Jones, M.B, Blaesius, R, Harden, T.K, Sondek, J, Watts, V.J, Ramer, J.K, Siderovski, D.P. | 登録日 | 2004-11-24 | 公開日 | 2005-07-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange Structure, 7, 2005
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1FOE
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![BU of 1foe by Molmil](/molmil-images/mine/1foe) | |
4K44
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![BU of 4k44 by Molmil](/molmil-images/mine/4k44) | |
2NZ8
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![BU of 2nz8 by Molmil](/molmil-images/mine/2nz8) | N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 | 分子名称: | ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein | 著者 | Chhatriwala, M.K, Betts, L, Worthylake, D.K, Sondek, J. | 登録日 | 2006-11-22 | 公開日 | 2007-04-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation J.Mol.Biol., 368, 2007
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2PBI
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![BU of 2pbi by Molmil](/molmil-images/mine/2pbi) | The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure | 分子名称: | GLYCEROL, Guanine nucleotide-binding protein subunit beta 5, Regulator of G-protein signaling 9 | 著者 | Cheever, M.L, Snyder, J.T, Gershburg, S, Siderovski, D.P, Harden, T.K, Sondek, J. | 登録日 | 2007-03-28 | 公開日 | 2008-01-29 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat.Struct.Mol.Biol., 15, 2008
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2NUD
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![BU of 2nud by Molmil](/molmil-images/mine/2nud) | The structure of the type III effector AvrB complexed with a high-affinity RIN4 peptide | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Avirulence B protein, RPM1-interacting protein 4, ... | 著者 | Singer, A.U, Desveaux, D, Wu, A.J, McNulty, B, Sondek, J, Dangl, J.L. | 登録日 | 2006-11-09 | 公開日 | 2007-05-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction. Plos Pathog., 3, 2007
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2NUN
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![BU of 2nun by Molmil](/molmil-images/mine/2nun) | The structure of the type III effector AvrB complexed with ADP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Avirulence B protein | 著者 | Singer, A.U, Desveaux, D, Wu, A.J, McNulty, B, Dangl, J.L, Sondek, J. | 登録日 | 2006-11-09 | 公開日 | 2007-05-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction. Plos Pathog., 3, 2007
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2PZ1
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1KZ7
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![BU of 1kz7 by Molmil](/molmil-images/mine/1kz7) | Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 | 分子名称: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | 著者 | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | 登録日 | 2002-02-06 | 公開日 | 2002-03-20 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21, 2002
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1KZG
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![BU of 1kzg by Molmil](/molmil-images/mine/1kzg) | DbsCdc42(Y889F) | 分子名称: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | 著者 | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | 登録日 | 2002-02-06 | 公開日 | 2002-03-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21, 2002
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1IHJ
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1S21
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![BU of 1s21 by Molmil](/molmil-images/mine/1s21) | Crystal Structure of AvrPphF ORF2, A Type III Effector from P. syringae | 分子名称: | ORF2 | 著者 | Singer, A.U, Desveaux, D, Betts, L, Chang, J.H, Nimchuk, Z, Grant, S.R, Dangl, J.K, Sondek, J. | 登録日 | 2004-01-07 | 公開日 | 2004-09-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis Structure, 12, 2004
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1KI1
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![BU of 1ki1 by Molmil](/molmil-images/mine/1ki1) | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | 分子名称: | G25K GTP-binding protein, placental isoform, SULFATE ION, ... | 著者 | Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. | 登録日 | 2001-12-02 | 公開日 | 2002-05-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
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1S28
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![BU of 1s28 by Molmil](/molmil-images/mine/1s28) | Crystal Structure of AvrPphF ORF1, the Chaperone for the Type III Effector AvrPphF ORF2 from P. syringae | 分子名称: | ORF1, SULFATE ION | 著者 | Singer, A.U, Desveaux, D, Betts, L, Chang, J.H, Nimchuk, Z, Grant, S.R, Dangl, J.L, Sondek, J. | 登録日 | 2004-01-08 | 公開日 | 2004-09-14 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structures of the Type III Effector Protein AvrPphF and Its Chaperone Reveal Residues Required for Plant Pathogenesis Structure, 12, 2004
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1JAD
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![BU of 1jad by Molmil](/molmil-images/mine/1jad) | C-terminal Domain of Turkey PLC-beta | 分子名称: | SULFATE ION, phospholipase C beta | 著者 | Singer, A.U, Waldo, G.L, Harden, T.K, Sondek, J. | 登録日 | 2001-05-30 | 公開日 | 2001-12-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. Nat.Struct.Biol., 9, 2002
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1LB1
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![BU of 1lb1 by Molmil](/molmil-images/mine/1lb1) | Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA | 分子名称: | Guanine nucleotide exchange factor DBS, Transforming protein RhoA | 著者 | Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J. | 登録日 | 2002-04-01 | 公開日 | 2002-05-29 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
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