6ZE1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ze1 by Molmil](/molmil-images/mine/6ze1) | human NBD1 of CFTR in complex with nanobody G11a | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ... | 著者 | Garcia-Pino, A, Govaerts, C, Scholl, D, Sigoillot, M. | 登録日 | 2020-06-15 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | 主引用文献 | A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Nat.Chem.Biol., 17, 2021
|
|
3J9R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3j9r by Molmil](/molmil-images/mine/3j9r) | Atomic structures of a bactericidal contractile nanotube in its pre- and post-contraction states | 分子名称: | sheath | 著者 | Ge, P, Scholl, D, Leiman, P.G, Yu, X, Miller, J.F, Zhou, Z.H. | 登録日 | 2015-02-17 | 公開日 | 2015-04-01 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states. Nat.Struct.Mol.Biol., 22, 2015
|
|
3J9Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3j9q by Molmil](/molmil-images/mine/3j9q) | Atomic structures of a bactericidal contractile nanotube in its pre- and post-contraction states | 分子名称: | sheath, tube | 著者 | Ge, P, Scholl, D, Leiman, P.G, Yu, X, Miller, J.F, Zhou, Z.H. | 登録日 | 2015-02-17 | 公開日 | 2015-04-01 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Atomic structures of a bactericidal contractile nanotube in its pre- and postcontraction states. Nat.Struct.Mol.Biol., 22, 2015
|
|
6PYT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6pyt by Molmil](/molmil-images/mine/6pyt) | CryoEM Structure of Pyocin R2 - precontracted - trunk | 分子名称: | Pyocin sheath PA0622, Pyocin tube PA0623 | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-07-30 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
6GJQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gjq by Molmil](/molmil-images/mine/6gjq) | human NBD1 of CFTR in complex with nanobody T27 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, Nanobody T27 | 著者 | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | 登録日 | 2018-05-16 | 公開日 | 2019-06-19 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
|
|
6GKD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gkd by Molmil](/molmil-images/mine/6gkd) | human NBD1 of CFTR in complex with nanobodies D12 and G3a | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... | 著者 | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | 登録日 | 2018-05-18 | 公開日 | 2019-06-19 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
|
|
6GJU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gju by Molmil](/molmil-images/mine/6gju) | human NBD1 of CFTR in complex with nanobodies T2a and T4 | 分子名称: | Cystic fibrosis transmembrane conductance regulator, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | 登録日 | 2018-05-17 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
|
|
6GJS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gjs by Molmil](/molmil-images/mine/6gjs) | Human NBD1 of CFTR in complex with nanobodies D12 and T4 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ... | 著者 | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | 登録日 | 2018-05-16 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
|
|
6GK4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gk4 by Molmil](/molmil-images/mine/6gk4) | Human NBD1 of CFTR in complex with nanobodies D12 and T8 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... | 著者 | Sigoillot, M, Overtus, M, Grodecka, M, Scholl, D, Garcia-Pino, A, Laeremans, T, He, L, Pardon, E, Hildebrandt, E, Urbatsch, I, Steyaert, J, Riordan, J.R, Govaerts, C. | 登録日 | 2018-05-18 | 公開日 | 2019-06-19 | 最終更新日 | 2019-08-21 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Domain-interface dynamics of CFTR revealed by stabilizing nanobodies. Nat Commun, 10, 2019
|
|
6U5B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u5b by Molmil](/molmil-images/mine/6u5b) | CryoEM Structure of Pyocin R2 - precontracted - baseplate | 分子名称: | Glue PA0627, Ripcord PA0626, Sheath Initiator PA0617, ... | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
6U5H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u5h by Molmil](/molmil-images/mine/6u5h) | CryoEM Structure of Pyocin R2 - precontracted - hub | 分子名称: | Probable bacteriophage protein Pyocin R2 | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
6U5K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u5k by Molmil](/molmil-images/mine/6u5k) | CryoEM Structure of Pyocin R2 - postcontracted - baseplate | 分子名称: | Glue PA0627, Sheath Initiator PA0617, Sheath PA0622, ... | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
6U5F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u5f by Molmil](/molmil-images/mine/6u5f) | CryoEM Structure of Pyocin R2 - precontracted - collar | 分子名称: | Collar PA0615, Sheath PA0622, Tube PA0623 | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
6U5J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6u5j by Molmil](/molmil-images/mine/6u5j) | CryoEM Structure of Pyocin R2 - postcontracted - collar | 分子名称: | Collar PA0615, Sheath PA0622 | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
|
|
6CL5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cl5 by Molmil](/molmil-images/mine/6cl5) | Structure of P. aeruginosa R1 pyocin fiber PALES_06171 comprising C-terminal residues 323-701 | 分子名称: | FE (III) ION, MAGNESIUM ION, SODIUM ION, ... | 著者 | Buth, S.A, Shneider, M.M, Leiman, P.G. | 登録日 | 2018-03-01 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.324 Å) | 主引用文献 | Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers. Viruses, 10, 2018
|
|
5CES
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ces by Molmil](/molmil-images/mine/5ces) | |
5W5E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5w5e by Molmil](/molmil-images/mine/5w5e) | Re-refinement of the pyocin tube structure | 分子名称: | FIIR2 protein | 著者 | Wang, F, Zheng, W, Taylor, N.M, Guerrero-Ferreira, R.C, Leiman, P.G, Egelman, E.H. | 登録日 | 2017-06-15 | 公開日 | 2017-08-16 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit. Structure, 25, 2017
|
|
6CL6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6cl6 by Molmil](/molmil-images/mine/6cl6) | Structure of P. aeruginosa R2 pyocin fiber PA0620 comprising C-terminal residues 323-691 | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, FE (III) ION, ... | 著者 | Buth, S.A, Shneider, M.M, Leiman, P.G. | 登録日 | 2018-03-01 | 公開日 | 2018-06-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers. Viruses, 10, 2018
|
|
6S2V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s2v by Molmil](/molmil-images/mine/6s2v) | |
6S2T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s2t by Molmil](/molmil-images/mine/6s2t) | |
6S2U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6s2u by Molmil](/molmil-images/mine/6s2u) | |
8BZP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bzp by Molmil](/molmil-images/mine/8bzp) | JNK3 (Mitogen-activated protein kinase 10) in Complex with Compound 23 bearing a C(sp3)F2Br moiety | 分子名称: | 1,2-ETHANEDIOL, 2-bromanyl-2,2-bis(fluoranyl)-~{N}-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)ethanamide, BETA-MERCAPTOETHANOL, ... | 著者 | Stahlecker, J, Vaas, S, Stehle, T, Boeckler, F.M. | 登録日 | 2022-12-15 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Principles and Applications of CF 2 X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery. J.Med.Chem., 66, 2023
|
|
6EQ9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6eq9 by Molmil](/molmil-images/mine/6eq9) | Crystal structure of JNK3 in complex with AMP-PCP | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Macedo, J.T, Stehle, T, Blaum, B.S. | 登録日 | 2017-10-12 | 公開日 | 2018-08-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega, 3, 2018
|
|
6EKD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ekd by Molmil](/molmil-images/mine/6ekd) | Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-(4-methyl-2-methylsulfanyl-1~{H}-imidazol-5-yl)-~{N}-(4-morpholin-4-ylphenyl)pyridin-2-amine, BETA-MERCAPTOETHANOL, ... | 著者 | Macedo, J.T, Stehle, T, Blaum, B.S. | 登録日 | 2017-09-26 | 公開日 | 2018-08-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega, 3, 2018
|
|
6EMH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6emh by Molmil](/molmil-images/mine/6emh) | Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor | 分子名称: | 1,2-ETHANEDIOL, 4-(4-methyl-1~{H}-imidazol-5-yl)-~{N}-(4-morpholin-4-ylphenyl)pyridin-2-amine, BETA-MERCAPTOETHANOL, ... | 著者 | Macedo, J.T, Stehle, T, Blaum, B.S. | 登録日 | 2017-10-02 | 公開日 | 2018-08-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega, 3, 2018
|
|