6EKD

Crystal structure of JNK3 in complex with a pyridinylimidazole inhibitor

Summary for 6EKD

Entry DOI	10.2210/pdb6ekd/pdb
Descriptor	Mitogen-activated protein kinase 10, BETA-MERCAPTOETHANOL, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	protein kinase activity map kinase activity atp binding protein phosphorylation, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42782.55
Authors	Macedo, J.T.,Stehle, T.,Blaum, B.S. (deposition date: 2017-09-26, release date: 2018-08-08, Last modification date: 2024-01-17)
Primary citation	Ansideri, F.,Macedo, J.T.,Eitel, M.,El-Gokha, A.,Zinad, D.S.,Scarpellini, C.,Kudolo, M.,Schollmeyer, D.,Boeckler, F.M.,Blaum, B.S.,Laufer, S.A.,Koch, P. Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38 alpha Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. ACS Omega, 3:7809-7831, 2018 Cited by PubMed: 30087925 DOI: 10.1021/acsomega.8b00668 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation