2QPF
 
 | | Crystal Structure of Mouse Transthyretin | | 分子名称: | Transthyretin | | 著者 | Reixach, N, Foss, T.R, Santelli, E, Pascual, J, Kelly, J.W, Buxbaum, J.N. | | 登録日 | 2007-07-23 | | 公開日 | 2007-11-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Human-Murine Transthyretin Heterotetramers Are Kinetically Stable and Non-amyloidogenic: A LESSON IN THE GENERATION OF TRANSGENIC MODELS OF DISEASES INVOLVING OLIGOMERIC PROTEINS.
J.Biol.Chem., 283, 2008
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4HIQ
 | | The Structure of V122I Mutant Transthyretin in Complex with AG10 | | 分子名称: | 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin | | 著者 | Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. | | 登録日 | 2012-10-11 | | 公開日 | 2013-06-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HIS
 | | The Structure of V122I Mutant Transthyretin in Complex with Tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A. | | 登録日 | 2012-10-11 | | 公開日 | 2013-06-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3P3T
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3P3R
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3P3U
 | | Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole | | 分子名称: | 4-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine, Transthyretin | | 著者 | Connelly, S, Wilson, I.A. | | 登録日 | 2010-10-05 | | 公開日 | 2011-08-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3, 2011
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3P3S
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3HJ0
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3IMR
 | | Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dichlorostyryl)phenol | | 分子名称: | 2,6-dibromo-4-[(E)-2-(2,6-dichlorophenyl)ethenyl]phenol, Transthyretin | | 著者 | Connelly, S, Wilson, I.A. | | 登録日 | 2009-08-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132, 2010
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3IMW
 | | Transthyretin in complex with (E)-2,6-dibromo-4-(2,6-dimethoxystyryl)aniline | | 分子名称: | 2,6-dibromo-4-[(E)-2-(2,6-dimethoxyphenyl)ethenyl]aniline, Transthyretin | | 著者 | Connelly, S, Wilson, I.A. | | 登録日 | 2009-08-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132, 2010
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3IMS
 | | Transthyretin in complex with 2,6-dibromo-4-(2,6-dichlorophenethyl)phenol | | 分子名称: | 2,6-dibromo-4-[2-(2,6-dichlorophenyl)ethyl]phenol, Transthyretin | | 著者 | Connelly, S, Wilson, I.A. | | 登録日 | 2009-08-11 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132, 2010
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3IMT
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3IMU
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3IMV
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