3HJ0
Transthyretin in complex with a covalent small molecule kinetic stabilizer
Summary for 3HJ0
Entry DOI | 10.2210/pdb3hj0/pdb |
Related | 3CN1 3CN2 3CN3 3CN4 |
Descriptor | Transthyretin, 4-fluorophenyl 3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoate (3 entities in total) |
Functional Keywords | hormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28343.51 |
Authors | Connelly, S.,Wilson, I.A.,Kelly, J.W. (deposition date: 2009-05-20, release date: 2009-12-22, Last modification date: 2014-11-19) |
Primary citation | Choi, S.,Connelly, S.,Reixach, N.,Wilson, I.A.,Kelly, J.W. Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nat.Chem.Biol., 6:133-139, 2010 Cited by PubMed: 20081815DOI: 10.1038/nchembio.281 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.34 Å) |
Structure validation
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