3P3S
Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one
Summary for 3P3S
Entry DOI | 10.2210/pdb3p3s/pdb |
Related | 3IMR 3IMS 3IMT 3IMU 3P3R 3P3T 3P3U |
Descriptor | Transthyretin, (5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one (3 entities in total) |
Functional Keywords | hormone, t4, retinol binding protein, hormone-binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 29054.78 |
Authors | Connelly, S.,Wilson, I.A. (deposition date: 2010-10-05, release date: 2011-08-24, Last modification date: 2023-09-06) |
Primary citation | Alhamadsheh, M.M.,Connelly, S.,Cho, A.,Reixach, N.,Powers, E.T.,Pan, D.W.,Wilson, I.A.,Kelly, J.W.,Graef, I.A. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3:97ra81-97ra81, 2011 Cited by PubMed: 21865539DOI: 10.1126/scitranslmed.3002473 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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