3P3U

Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole

Summary for 3P3U

• Entry DOI: 10.2210/pdb3p3u/pdb
• Related: 3IMR 3IMS 3IMT 3IMU 3P3R 3P3S 3P3T
• Descriptor: Transthyretin, 4-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine (3 entities in total)
• Functional Keywords: hormone, t4, retinol binding protein, hormone-binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28089.29

Authors

Connelly, S.,Wilson, I.A. (deposition date: 2010-10-05, release date: 2011-08-24, Last modification date: 2023-09-06)

• Primary citation: Alhamadsheh, M.M.,Connelly, S.,Cho, A.,Reixach, N.,Powers, E.T.,Pan, D.W.,Wilson, I.A.,Kelly, J.W.,Graef, I.A.; Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.; Sci Transl Med, 3:97ra81-97ra81, 2011; PubMed: 21865539; DOI: 10.1126/scitranslmed.3002473

Experimental method

X-RAY DIFFRACTION (1.5 Å)