3P3R

Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone

Summary for 3P3R

• Entry DOI: 10.2210/pdb3p3r/pdb
• Related: 3IMR 3IMS 3IMT 3IMU 3P3S 3P3T 3P3U
• Descriptor: Transthyretin, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone (3 entities in total)
• Functional Keywords: hormone, t4, retinol binding protein, hormone-binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28109.13

Authors

Connelly, S.,Wilson, I.A. (deposition date: 2010-10-05, release date: 2011-08-24, Last modification date: 2023-09-06)

• Primary citation: Alhamadsheh, M.M.,Connelly, S.,Cho, A.,Reixach, N.,Powers, E.T.,Pan, D.W.,Wilson, I.A.,Kelly, J.W.,Graef, I.A.; Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.; Sci Transl Med, 3:97ra81-97ra81, 2011; PubMed: 21865539; DOI: 10.1126/scitranslmed.3002473

Experimental method

X-RAY DIFFRACTION (1.25 Å)