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3P3T

Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole

Summary for 3P3T
Entry DOI10.2210/pdb3p3t/pdb
Related3IMR 3IMS 3IMT 3IMU 3P3R 3P3S 3P3U
DescriptorTransthyretin, 4-[3-(2-fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole (3 entities in total)
Functional Keywordshormone, t4, retinol binding protein, hormone-binding protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28051.31
Authors
Connelly, S.,Wilson, I.A. (deposition date: 2010-10-05, release date: 2011-08-24, Last modification date: 2023-09-06)
Primary citationAlhamadsheh, M.M.,Connelly, S.,Cho, A.,Reixach, N.,Powers, E.T.,Pan, D.W.,Wilson, I.A.,Kelly, J.W.,Graef, I.A.
Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.
Sci Transl Med, 3:97ra81-97ra81, 2011
Cited by
PubMed: 21865539
DOI: 10.1126/scitranslmed.3002473
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

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