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8PWZ
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BU of 8pwz by Molmil
Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadBD from Mycobacterium tuberculosis
分子名称: (3R)-hydroxyacyl-ACP dehydratase subunit HadB, UPF0336 protein Rv0504c
著者Rima, J, Grimoire, Y, Bories, P, Bardou, F, Quemard, A, Bon, C, Mourey, L, Tranier, S.
登録日2023-07-22
公開日2024-03-27
実験手法X-RAY DIFFRACTION (2.00196719 Å)
主引用文献HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II: A singular structure for a unique function.
Protein Sci., 33, 2024
2NTN
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BU of 2ntn by Molmil
Crystal structure of MabA-C60V/G139A/S144L
分子名称: 3-oxoacyl-[acyl-carrier-protein] reductase
著者Poncet-Montange, G, Ducasse-Cabanot, S, Quemard, A, Labesse, G, Cohen-Gonsaud, M.
登録日2006-11-08
公開日2006-11-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
1ENY
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BU of 1eny by Molmil
CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
分子名称: ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日1995-01-27
公開日1996-01-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science, 267, 1995
1ENZ
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BU of 1enz by Molmil
CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
分子名称: ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日1995-01-27
公開日1996-01-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science, 267, 1995
1UZL
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BU of 1uzl by Molmil
MabA from Mycobacterium tuberculosis
分子名称: 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE, CESIUM ION
著者Cohen-Gonsaud, M, Ducasse, S, Quemard, A, Labesse, G.
登録日2004-03-14
公開日2005-03-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Maba from Mycobacterium Tuberculosis, a Reductase Involved in Long-Chain Fatty Acid Biosynthesis.
J.Mol.Biol., 320, 2002
1UZN
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BU of 1uzn by Molmil
MabA from Mycobacterium tuberculosis
分子名称: 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE, CESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Cohen-Gonsaud, M, Ducasse, S, Quemard, A, Labesse, G.
登録日2004-03-14
公開日2005-03-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal Structure of Maba from Mycobacterium Tuberculosis, a Reductase Involved in Long-Chain Fatty Acid Biosynthesis.
J.Mol.Biol., 320, 2002
1UZM
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BU of 1uzm by Molmil
MabA from Mycobacterium tuberculosis
分子名称: 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE, CESIUM ION
著者Cohen-Gonsaud, M, Ducasse, S, Quemard, A, Labesse, G.
登録日2004-03-14
公開日2005-03-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Crystal Structure of Maba from Mycobacterium Tuberculosis, a Reductase Involved in Long-Chain Fatty Acid Biosynthesis.
J.Mol.Biol., 320, 2002
5I0K
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BU of 5i0k by Molmil
Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases
分子名称: CROTONYL COENZYME A, Phthiocerol synthesis polyketide synthase type I PpsC
著者Faille, A, Mourey, L, Pedelacq, J.D.
登録日2016-02-04
公開日2017-08-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.197 Å)
主引用文献Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
5L84
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BU of 5l84 by Molmil
Structure of the H959F variant of the PpsC dehydratase domain from Mycobacterium tuberculosis
分子名称: Phthiocerol synthesis polyketide synthase type I PpsC
著者Faille, A, Gavalda, S, Mourey, L, Pedelacq, J.D.
登録日2016-06-07
公開日2017-08-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
5NJI
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BU of 5nji by Molmil
Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA
分子名称: Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate
著者Gavalda, S, Faille, A, Mourey, L, Pedelacq, J.D.
登録日2017-03-28
公開日2017-05-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.
J. Mol. Biol., 429, 2017
4OOC
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BU of 4ooc by Molmil
Dehydratase domain of the polyketide PpsC from Mycobacterium tuberculosis
分子名称: PHOSPHATE ION, Phthiocerol synthesis polyketide synthase type I PpsC
著者Faille, A, Mourey, L, Pedelacq, J.D.
登録日2014-01-31
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
4OKI
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BU of 4oki by Molmil
X-ray structure of the nucleotide-binding subdomain of the enoylreductase domain of PpsC from Mycobacterium tuberculosis
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Phthiocerol synthesis polyketide synthase type I PpsC, SODIUM ION
著者Faille, A, Mourey, L, Pedelacq, J.D.
登録日2014-01-22
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Insights into the catalytic mechanism of the DH domain of the Mycobacterium tuberculosis polyketide synthase PpsC and architecture of the beta-carbon processing domains
To be Published
2FK8
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BU of 2fk8 by Molmil
Crystal structure of Hma (MmaA4) from Mycobacterium tuberculosis complexed with S-adenosylmethionine
分子名称: S-ADENOSYLMETHIONINE, methoxy mycolic acid synthase 4
著者Boissier, F, Guillet, V, Mourey, L.
登録日2006-01-04
公開日2006-01-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis.
J.Biol.Chem., 281, 2006
2FK7
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BU of 2fk7 by Molmil
Crystal structure of Hma (MmaA4) from Mycobacterium tuberculosis, apo-form
分子名称: methoxy mycolic acid synthase 4
著者Boissier, F, Guillet, V, Mourey, L.
登録日2006-01-04
公開日2006-01-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis.
J.Biol.Chem., 281, 2006
1ZID
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BU of 1zid by Molmil
LONG FATTY ACID CHAIN ENOYL-ACP REDUCTASE (INHA) IN COMPLEX WITH AN ISONICOTINIC-ACYL-NADH INHIBITOR
分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE
著者Rozwarski, D.A, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日1997-03-25
公開日1998-03-25
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Science, 279, 1998
3HA5
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BU of 3ha5 by Molmil
Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with sinefungin
分子名称: METHOXY MYCOLIC ACID SYNTHASE 4, SINEFUNGIN
著者Boissier, F, Vaubourgeix, J, Julien, S, Mourey, L.
登録日2009-05-01
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献SADAE, A potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases
To be Published
3HA3
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BU of 3ha3 by Molmil
Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with S-adenosylhomocysteine
分子名称: METHOXY MYCOLIC ACID SYNTHASE 4, S-ADENOSYL-L-HOMOCYSTEINE
著者Boissier, F, Vaubourgeix, J, Julien, S, Mourey, L.
登録日2009-05-01
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献SADAE, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases
To be Published
3HA7
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BU of 3ha7 by Molmil
Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with S-adenosyl-N-decyl-aminoethyl (SADAE)
分子名称: 5'-S-[2-(decylamino)ethyl]-5'-thioadenosine, METHOXY MYCOLIC ACID SYNTHASE 4
著者Vaubourgeix, J, Boissier, F, Julien, S, Mourey, L.
登録日2009-05-01
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献SADAE, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases
To be Published
3TZX
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BU of 3tzx by Molmil
Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in tetragonal apo form at 2.3 A
分子名称: 12-mer peptide, GLYCEROL, Polyketide synthase PKS13, ...
著者Bergeret, F, Pedelacq, J.D, Mourey, L, Bon, C.
登録日2011-09-28
公開日2012-08-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
J.Biol.Chem., 287, 2012
3TZY
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BU of 3tzy by Molmil
Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the palmitoylated form at 2.2 A
分子名称: 12-mer peptide, GLYCEROL, PALMITIC ACID, ...
著者Bergeret, F, Pedelacq, J.D, Mourey, L, Bon, C.
登録日2011-09-28
公開日2012-08-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
J.Biol.Chem., 287, 2012
3TZW
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Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the orthorhombic apoform at 2.6 A
分子名称: 1,2-ETHANEDIOL, 12-mer peptide, Polyketide synthase PKS13, ...
著者Bergeret, F, Pedelacq, J.D, Mourey, L, Bon, C.
登録日2011-09-28
公開日2012-08-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
J.Biol.Chem., 287, 2012
3TZZ
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BU of 3tzz by Molmil
Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the carboxypalmitoylated form at 2.5 A
分子名称: 12-mer peptide, 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, ...
著者Bergeret, F, Pedelacq, J.D, Mourey, L, Bon, C.
登録日2011-09-28
公開日2012-08-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
J.Biol.Chem., 287, 2012

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